Mammary gland hyperplasia-treating capsule and preparation method thereof

A technology of soft capsules and capsule shells, which is applied in capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc. It can solve the problems of capsule shell hardening and soft capsule instability, and achieve increased purity and stable product quality. good sex effect

Active Publication Date: 2011-05-04
蚌埠丰原涂山制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The active ingredients extracted by the patented method were made into soft capsules. It was found that the soft capsules were unstable and the capsule shell was hardened. In order to overcome the above problems, the inventor improved the extraction method and provided a stable capsule with appropriate auxiliary materials. Softgels

Method used

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  • Mammary gland hyperplasia-treating capsule and preparation method thereof
  • Mammary gland hyperplasia-treating capsule and preparation method thereof
  • Mammary gland hyperplasia-treating capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: Ruzengning active ingredient extraction method

[0039] 1) Weigh Artemisia argyi, Epimedium, Bupleurum, Toosendan, Asparagus, and Fritillaria in a weight ratio of 2:1:1:1:1:1.2, mix them, add water to decoct, and add them for the first time Boil 10 times the amount of water for 1.5 hours; add 8 times the amount of water for the second time and boil for 1 hour; add 8 times the amount of water for the third time and boil for 1 hour, and the relative density of vacuum concentration is 1.28 (85°C);

[0040] 2) Stir while it is hot and add ethanol to make the alcohol concentration reach 70% (the amount of alcohol added is about three times the amount of the liquid medicine), continue to stir fully, let the alcohol precipitation solution stand for 24 hours, and take the supernatant;

[0041] 3) The precipitate was washed twice with a small amount of 70% ethanol and then merged with the supernatant, and the ethanol was recovered under reduced pressure to obtain the...

Embodiment 2

[0044] 1. Composition of soft capsules

[0045] Wherein the composition of capsule shell: 10 parts of gelatin, 3.2 parts of glycerin, 9 parts of water (weight ratio).

[0046] 2, the concrete composition of soft capsule content is: wherein active ingredient adopts the method preparation of embodiment 1:

[0047] Content composition Weight (mg) Weight percentage (%)

[0048] Active ingredient (according to extract dry powder) 4 53.12

[0049] Polyethylene glycol 2000 3 39.84

[0050] Chitosan 0.25 3.32

[0051] Hydroxypropyl methylcellulose 0.13 1.73

[0052] Ascorbic acid 0.1 1.33

[0053] Methylparaben 0.05 0.66

[0054] Total 7.53 100

[0055] 3. The preparation method is:

[0056] 1) Preparation of the capsule shell liquid: According to the prescription ratio, mix the gelatin, glycerin and water of the capsule shell evenly, heat and dissolve in a water bath at 80°C, add an appropriate amount of methyl p-hydroxybenzoate, stir, vacuumize and degas, 70 ℃ heat preserva...

Embodiment 3

[0060] 1. The composition of the soft capsule, wherein the composition of the capsule shell: 10 parts of gelatin, 3.5 parts of glycerin, and 9 parts of water (weight ratio).

[0061] 2. The specific composition of the soft capsule content is: wherein the active ingredient is prepared by the method of Example 1

[0062] Content composition weight (mg) weight percentage (%)

[0063] Active ingredient (according to extract dry powder) 4 46.73

[0064] Polyethylene glycol 400 4 46.73

[0065] Glycerin 0.28 3.27

[0066] Hydroxypropyl methylcellulose 0.1 1.17

[0067] Ascorbic acid 0.14 1.63

[0068] Methylparaben 0.04 0.47

[0069] Total 8.56 100

[0070] 3. The preparation method is:

[0071] 1) Preparation of the capsule shell liquid: According to the prescription ratio, mix the gelatin, glycerin and water of the capsule shell evenly, heat and dissolve in a water bath at 80°C, add an appropriate amount of methyl p-hydroxybenzoate, stir, vacuumize and degas, 70 ℃ heat pre...

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Abstract

The invention provides a mammary gland hyperplasia-treating capsule comprising a capsule shell and inclusions, wherein the capsule shell comprises the following components in parts by weight: 10 parts of gelatin, 3.2-3.6 parts of glycerol and 9 parts of water; and the inclusions in the capsule shell comprise the following components in percentage by weight: 25-60% of active constituents, 35-70% of diluent, 1-5% of suspending aid, 0-5% of antioxidant and 0-5% of preservative, and the active constituents are prepared from Chinese mugwort leaf, epimedium herb, the root of Chinese thorowax, szechwan Chinaberry fruit, cochinchnese asparagus root and rhizoma bolbostemmae by the weight ratio of 2:1:1:1:1:1.2. The mammary gland hyperplasia-treating capsule provided by the invention has the advantages of stable quality, convenience for carrying and taking, fast effect on dissolving out, high bioavilability and good clinical effect.

Description

technical field [0001] The invention relates to a soft capsule and a preparation method thereof, in particular to a Ruzengning soft capsule for treating mammary gland hyperplasia and a preparation method thereof. Background technique [0002] Breast hyperplasia is the most common breast disease in women, and its incidence rate accounts for the first place in breast diseases. In recent years, the incidence of the disease has been increasing year by year, and the age is getting younger and younger. Mammary gland hyperplasia refers to hyperplasia of mammary gland epithelium and fibrous tissue, structural degeneration of breast tissue ducts and lobules, and progressive growth of connective tissue. The main cause of the disease is endocrine hormone imbalance. [0003] Clinically, patients often feel breast distending pain, especially before menstruation. Early breast lobular hyperplasia will not become cancerous yet, and the canceration rate of middle and late breast diseases i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8965A61K9/48A61K47/42A61P15/14
Inventor 汪洪湖
Owner 蚌埠丰原涂山制药有限公司
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