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Moldavica dragonhead total flavone sustained release tablet and preparation method thereof

A technology of total flavonoids and sustained-release tablets, which is used in pharmaceutical formulations, medical preparations containing active ingredients, and drug delivery, etc., can solve the problems of inability to effectively exert medicinal effects, causing greater pressure on users, and frequent dosing. , to avoid toxic side effects, maintain curative effect, and easily control the quality

Inactive Publication Date: 2011-05-11
XINJIANG INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent announcement number is CN10537039A discloses a kind of preparation method and application of total flavonoids of sweet blue orchid, but, the deficiency that this method makes medicine exists is that its medicinal effect cannot be brought into play effectively
[0004] Chinese patent announcement number is that CN101219161A, CN101264129A disclose the preparation method of Xiangqinglan dripping pill and Xiangqinglan sugar-free granule respectively, but two kinds of dosage forms provided belong to quick-release dosage form, need more frequent administration, give Takers cause greater stress

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: first the total flavonoids of sweet blue orchid is produced through the following process: the sweet green orchid is pulverized into coarse powder, crosses 0.8mm, adds 30 times of amount of 70% ethanol to extract and reflux 2 times, each time for 3 hours, use Filter through a 70 μm sieve, combine the filtrates twice, recover ethanol, and concentrate to a 0.35 g / mL sweet green orchid concentrate; take the above concentrate and purify it with HPD100 macroporous resin, and add 6 mL of ethanol per gram of dry resin Purify according to the ratio of the concentrated solution. After standing for adsorption for 4 hours, use 40mL water for each g of dry resin at a rate of 40mL·h -1 The flow rate is eluted, and the eluent is discarded; and then 120mL60% ethanol solution is used for each g of dry resin at 30mL·h -1 Flow rate elution, collect the eluate, and concentrate the eluate to a dry matter ≥ 1g / mL total flavonoids of cypress. Then take 35 parts of total flavon...

Embodiment 2

[0021] Example 2: Firstly, the total flavonoids of Cymbidium flavonoids are produced through the following process: Pulverize Chrysanthemum pansyllum into coarse powder, pass through 1mm, add 40 times the amount of 80% ethanol to extract and reflux 3 times, each time for 4 hours, with 80 μm Sieve and filter, combine the filtrates for 3 times, then recover ethanol, concentrate to 0.3g / mL sweet green blue concentrated solution; take the above concentrated solution, and use HPD400 macroporous resin for purification, add 6.5mL ethanol per g dry resin Purify according to the ratio of the concentrated solution. After standing for 5 hours of adsorption, use 50mL water for each g of dry resin at a rate of 50mL·h -1 The flow rate is eluted, and the eluent is discarded; then use 130mL65% ethanol solution for each g of dry resin at 40mL·h -1 Flow rate elution, collect the eluent, and concentrate the eluate to a dry matter ≥ 1.1g / mL total flavonoids of cypress. Then take 40 parts of tota...

Embodiment 3

[0022] Embodiment 3: first the total flavonoids of sweet blue orchid is produced by the following process: the sweet green orchid is pulverized into coarse powder, crosses 1.2mm, adds 50 times the amount of 90% ethanol to extract and reflux 4 times, each time for 6 hours, use Filter through a 100 μm sieve, combine the filtrates for 4 times, recover ethanol, and concentrate into a concentrated solution of 0.25g / mL fennel; take the above-mentioned concentrated solution and purify it with HPD600 macroporous resin, and add 8mL of ethanol per g of dry resin Purify according to the ratio of the concentrated solution. After standing for 7 hours of adsorption, use 60mL water for each g of dry resin at a rate of 70mL·h -1 The flow rate is eluted, and the eluent is discarded; then use 140mL70% ethanol solution for each g of dry resin at 50mL·h -1 Flow rate elution, collect the eluate, and concentrate the eluate to a dry matter ≥ 1g / mL total flavonoids of cypress. Then take 45 parts of ...

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Abstract

The invention discloses a moldavica dragonhead total flavone sustained release tablet and a preparation method thereof. The moldavica dragonhead total flavone sustained release tablet is prepared by mixing, granulating and tabletting moldavica dragonhead total flavone, a framework material, filler, a caking agent and a lubricating agent. Compared with the prior art, the moldavica dragonhead total flavone sustained release tablet prepared by the method disclosed by the invention has the advantages of short development period, simple and easy production process, suitability for bulk production, favorable medicine release performance, favorable safety performance, simpler prescription, low research and development cost, convenience for taking, easy control for quality and the like. In addition, after the medicine is administrated, the slow release at non constant-speed can be realized, the blood-medicine concentration is more stable, the peak valley fluctuation is smaller and the toxic or side effects due to multiple administrations with the result that the blood-medicine concentration exceeds the treatment range can be avoided. Meanwhile, the moldavica dragonhead total flavone sustained release tablet can be maintained in the effective concentration range for a longer time so as to maintain the curative effect and improve the safety, the effectiveness and the adaptability of the medicine; and the medicine administration frequency each day is reduced to 1-2 times from 3-4 times, thus the moldavica dragonhead total flavone sustained release tablet is greatly convenient for patients and particularly patients required to administrate the medicine for a long term.

Description

technical field [0001] The invention relates to a sustained-release tablet of total flavonoids of Xiangqinglan and a preparation method thereof. Background technique [0002] Dracocephalum Moldavica L. is an annual herb of Lamiaceae. It is a local Uighur medicine in Xinjiang and has rich medicinal resources. In Uighur medicine and folk, it is used to treat bronchitis, heart disease, high blood pressure and other diseases. The main components of Xiangqinglan are flavonoids and terpenoids, among which flavonoids have obvious protective effects on the myocardium. [0003] Chinese patent announcement number is CN10537039A discloses a kind of preparation method and application of the total flavonoids of sweet green orchid, but, the deficiency that this method makes medicine exists is that its medicinal effect can not be brought into play effectively. [0004] Chinese patent announcement number is that CN101219161A, CN101264129A disclose the preparation method of Xiangqinglan dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/22A61P9/00A61P9/10A61P11/00
Inventor 邢建国王新春薛桂蓬杨秀袁勇李悦
Owner XINJIANG INST OF MATERIA MEDICA
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