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Surface functional titanium material and preparation method thereof

A technology of surface functionalization and titanium material, which is applied in the field of biomedical materials to achieve the effect of reducing thrombosis, good application prospect and short cycle.

Inactive Publication Date: 2011-05-18
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far, there is no research report on the synergy of nanostructures and bioactive molecules to improve the endothelialization function of titanium surfaces at home and abroad.

Method used

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  • Surface functional titanium material and preparation method thereof
  • Surface functional titanium material and preparation method thereof
  • Surface functional titanium material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Embodiment 1, surface functionalized titanium material (TiO 2 Preparation of nanotubes with a diameter of 30nm)

[0034] Include the following steps:

[0035] a. Ultrasonic cleaning the titanium material with acetone, absolute ethanol, and deionized water for 10 minutes in sequence, and drying at 37°C for later use;

[0036] b, dissolving ammonium fluoride with a volume fraction of 50% ethanol solution to make a solution with a concentration of 0.27mol / L, as the electrolyte; then the titanium material pretreated in step a is used as the anode, and the platinum electrode is used as the cathode. In the above-mentioned ammonium fluoride electrolyte, electrolyze for 3 hours under the action of a direct current of 10V, soak the oxidized titanium material in deionized water for 2 hours, wash it with deionized water for 5 times, and dry it with nitrogen gas to obtain a tube with a surface. TiO with a diameter of 30nm 2 Titanium material of nanotube array (FE-SEM pictu...

Embodiment 2

[0041] Embodiment 2, surface functionalized titanium material (TiO 2 Preparation of nanotubes with a diameter of 60nm)

[0042] Include the following steps:

[0043] a. Ultrasonic cleaning the titanium material with acetone, absolute ethanol, and deionized water for 10 minutes in sequence, and drying at 37°C for later use;

[0044] b, dissolving ammonium fluoride with a volume fraction of 50% ethanol solution to make a solution with a concentration of 0.27mol / L, as the electrolyte; then the titanium material pretreated in step a is used as the anode, and the platinum electrode is used as the cathode. In the above-mentioned ammonium fluoride electrolyte, electrolyze for 3 hours under the action of a direct current of 20V, soak the oxidized titanium material in deionized water for 2 hours, wash it with deionized water for 5 times, and dry it with nitrogen gas to obtain a tube with a surface. TiO with a diameter of 60nm 2 Titanium material of nanotube array (FE-SEM pictu...

Embodiment 3

[0049] Embodiment 3, surface functionalized titanium material (TiO 2 Preparation of nanotubes with a diameter of 100nm)

[0050] Include the following steps:

[0051] a. Ultrasonic cleaning the titanium material with acetone, absolute ethanol, and deionized water for 10 minutes in sequence, and drying at 37°C for later use;

[0052] b, dissolving ammonium fluoride with a volume fraction of 50% ethanol solution to make a solution with a concentration of 0.27mol / L, as the electrolyte; then the titanium material pretreated in step a is used as the anode, and the platinum electrode is used as the cathode. In the above-mentioned ammonium fluoride electrolyte, electrolyze for 3 hours under the action of a direct current of 25V, soak the oxidized titanium material in deionized water for 2 hours, wash it with deionized water for 5 times, and dry it with nitrogen gas to obtain a tube with a surface. TiO with a diameter of 100nm 2 Titanium material of nanotube array (FE-SEM pic...

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Abstract

The invention belongs to the field of biomedical materials and relates to a surface functional titanium material. In the surface functional titanium material, the surface of the titanium material has a TiO2 nanometer tube array with the diameter of 30-60nm, and the surface of the TiO2 nanometer tube array is also fixed with a vascular endothelial growth factor (VEGF). A preparation method of the surface functional titanium material comprises the following steps of preparing the TiO2 nanometer tube array with the diameter of 30-60nm on the surface of the titanium material by adopting an anode oxidation process; carrying out silylanization treatment on the surface of the TiO2 nanometer tube array; introducing carboxyl onto the surface of the TiO2 nanometer tube array through chemical reaction; activating the carboxyl by utilizing carbodiimide and succinimide; and fixing the VEGF on the surface of the TiO2 nanometer tube array with the activated carboxyl through contact reaction to obtain the surface functional titanium material. The invention synergistically utilizes the VEGF and a TiO2 nanometer tube array structure with the diameter of 30-60nm to enhance the activity of endothelial cells of the surface of the titanium material and expression of a function index such as prostacyclin and can realize rapid endothelialization of the surface of a titanium substrate intravascular stent.

Description

technical field [0001] The invention belongs to the field of biomedical materials, relates to a surface-functionalized titanium material, and also relates to a preparation method of the titanium material. Background technique [0002] Titanium not only has good anti-fatigue, anti-corrosion and biocompatibility, but also has low magnetism and permeability, so it is an excellent material for preparing vascular stents. In recent years, vascular stents have been widely used in the treatment of cardiovascular diseases to support narrow or even blocked coronary arteries and ensure blood circulation. However, some problems have been exposed in the clinical application of titanium-based vascular stents, such as thrombosis, stent restenosis, and inflammatory reactions after stent implantation. [0003] Studies have shown that pre-endothelialization on the surface of vascular stents can improve the inflammatory response between the stent and blood vessels, change the patency rate of ...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/28A61L27/40A61L27/54
Inventor 蔡开勇杨再香
Owner CHONGQING UNIV
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