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Surface-hydrophilic molecularly imprinted polymer microsphere and preparation method thereof

A hydrophilic polymer and molecular imprinting technology, which is applied in the fields of alkali metal compounds, chemical instruments and methods, and other chemical processes, can solve the problem of affecting the molecular recognition ability of products, uncontrollable polymerization process, molecular imprinted polymer microsphere surface, etc. Issues such as uneven coverage

Active Publication Date: 2011-05-18
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The surface hydrophilic modification of molecularly imprinted polymer microspheres by the above-mentioned common free radical surface polymerization method has problems such as uneven surface coverage and uncontrollable polymerization process, which will affect the molecular recognition ability of the product.

Method used

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  • Surface-hydrophilic molecularly imprinted polymer microsphere and preparation method thereof
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  • Surface-hydrophilic molecularly imprinted polymer microsphere and preparation method thereof

Examples

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Effect test

example 1

[0029] Add 0.25mmol of 2,4-D into a 250mL round-bottomed flask filled with 60mL of methanol / water (4:1, v / v), stir it with a magnet to dissolve it completely, and then add 1mmol of 4-vinylpyridine. After full contact for half an hour, 5mmol EDMA, 0.44mmol chain transfer agent cumyl dithiobenzoate (CDB), 0.22mmol azobisisobutyronitrile (AIBN) and 20mL methanol / water (4:1 , v / v). After stirring for half an hour, the reaction system was sealed with argon gas for deoxygenation for 30 minutes, placed in a constant temperature oil bath at 60°C, reacted for 24 hours, and the reaction product was obtained by suction filtration.

[0030] The reaction product was subjected to Soxhelt extraction with methanol / acetic acid (9:1, v / v) for 48h, and then Soxhelt extraction with methanol for 12h. After air drying, vacuum drying at 40°C for 48 hours yielded molecularly imprinted polymer microspheres with narrow particle size distribution and RAFT chain transfer groups on the surface.

[0031]...

example 2

[0035] Add 0.25 mmol of 2,4-D into a 250 ml round-bottomed flask filled with 60 ml of methanol / water (4:1, v / v), stir with a magnet to dissolve it completely, and then add 1 mmol of 4-vinylpyridine. After full contact for half an hour, add 5mmol

[0036] EDMA, 0.44 mmol chain transfer agent CDB, 0.22 mmol AIBN and 20 ml of methanol / water (4:1, v / v). After stirring for half an hour, the reaction system was sealed with argon gas for deoxygenation for 30 minutes, placed in a constant temperature oil bath at 60°C, reacted for 24 hours, and the reaction product was obtained by suction filtration.

[0037] The reaction product was subjected to Soxhelt extraction with methanol / acetic acid (9:1, v / v) for 48h, and then Soxhelt extraction with methanol for 12h. After air drying, vacuum drying at 40°C for 48 hours yielded molecularly imprinted polymer microspheres with narrow particle size distribution and RAFT chain transfer groups on the surface.

[0038] In the preparation of non-im...

example 3

[0042] Add 0.25mmol theophylline and 30mL acetonitrile into a 100mL round bottom flask, stir to dissolve completely, then add 1mmol methacrylic acid, mix thoroughly for half an hour, then add 4mmol EDMA, 0.09mmol chain transfer agent CDB, 0.045mmolAIBN and 10 mL of acetonitrile. After stirring for half an hour, deoxygenate with argon for 30 minutes, seal the reaction system, place it in a constant temperature oil bath at 60°C, react for 24 hours, and filter with suction to obtain the reaction product.

[0043] The obtained polymer microspheres were subjected to Soxhelt extraction with methanol / acetic acid (9:1, v / v) for 48 hours, and then Soxhelt extraction with acetonitrile for 24 hours. Then vacuum-dried at 40°C for 48 hours to obtain molecularly imprinted polymer microspheres with narrow particle size distribution and chain transfer groups on the surface.

[0044] The preparation process of non-imprinted polymer microspheres is the same as above except that no template is ...

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Abstract

The invention relates to a surface-hydrophilic molecularly imprinted polymer microsphere and a preparation method thereof. The molecularly imprinted polymer microsphere has the crosslinking degree of over 60 percent and a grain size of 1 to 5mu m. The surface of the microsphere is provided with a hydrophilic polymer brush, and the microsphere has excellent molecular recognition performance on template molecules in a pure aqueous solution system. The microspheres are synthesized by a two-step process in reversible addition fragmentation chain transfer (RAFT) controlled free radical polymerization technology. The invention has the advantages of simple synthesis method, wide application range, pure products and the like. The prepared molecularly imprinted polymer microsphere has a wide application prospect in the fields of chromatographic stationary phases, biological sample analysis, medically clinical immunoassay, food and environment monitoring, mimic enzyme catalysis, bionic sensors and the like.

Description

Technical field [0001] The present invention relates to a method for preparing molecularly imprinted polymer microspheres with excellent molecular recognition function in a pure aqueous solution system, in particular to the preparation of molecularly imprinted polymer microspheres with hydrophilic polymer brushes on the surface Preparation. Background technique [0002] Molecular imprinting technology is a new interdisciplinary subject developed on the basis of polymer chemistry, biochemistry, materials chemistry and bionic technology in recent years. The molecularly imprinted polymers (Molecularly Imprinted Polymers, referred to as MIPs) obtained by it have the advantages of excellent affinity and specific selectivity for guest molecules, good stability and easy preparation, and thus become the research center in the field of molecular recognition in the world. hotspot. At present, molecularly imprinted polymers are mainly prepared by traditional free radical polymerizati...

Claims

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Application Information

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IPC IPC(8): B01J20/285B01J20/28B01J20/30
Inventor 张会旗潘国庆张莹
Owner NANKAI UNIV
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