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Preparation method for forsythoside A

A technology of forsythiaside and leaching, which is applied in the field of medicine, can solve the problems of complex process, expensive materials, and non-compliance with environmental protection requirements, and achieve the effect of simple process and reduced production cost

Inactive Publication Date: 2011-05-18
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the process is complicated, and a large amount of organic solvent is required to be washed during the separation process.
Chinese patents 200610027024.1, 200610027036.4, and 200610027037.9 also use organic solvents in large quantities, and the materials used are expensive and the production cost is high
[0004] The extraction and separation technology of forsythiaside A is now developing in a simple and environmentally friendly modern direction, but most of the processes in the literature and patents are still in the stage of organic reagent extraction and silica gel column separation. Environmental protection requirements, and, in the production operation process, it is also extremely inconvenient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Acid extraction: Take 1000 g of dried forsythia medicinal material, soak it with 10 times the amount of acid water with a pH value of 1 for 5 times, each time for 24 hours, filter with a 200-mesh filter cloth, and combine the filtrates.

[0020] (2) Resin separation: the above-mentioned filtrate is rinsed with acid water with a pH value of 1 for 1BV of the resin, and then separated with AB-8 resin. Rinse 3BV with 30% ethanol, collect the eluent, dry under reduced pressure at 60°C until no alcohol, and adjust the pH to 1.

[0021] (3) Separation of polyamides: Add 100-200 mesh polyamides to the separation liquid in the above (2), first rinse the resin 1BV with acid water with a pH value of 1, and then use 0.06% NaHCO 3 Wash 3BV of the solution, collect the lye, and adjust the pH to 1.

[0022] (4) Resin separation: The separation liquid in the above (3) is rinsed with acid water with a pH value of 1 to 2 for 1BV of the resin, then loaded with AB-8 resin, and the sam...

Embodiment 2

[0026] (1) Acid extraction: Take 5000 g of dried forsythia medicinal material, soak it in 20 times the amount of acid water with a pH value of 3 for 10 times, each time for 24 hours, filter with a 300-mesh filter cloth, and combine the filtrates.

[0027] (2) Resin separation: the above-mentioned filtrate was rinsed with acid water with a pH value of 2 for 4BV of resin, and then separated with AB-8 resin. Rinse 10BV with 50% ethanol, collect the alcohol eluate, dry under reduced pressure at 60°C until no alcohol, and adjust the pH to 3.

[0028] (3) Separation of polyamide: put 200-300 mesh polyamide on the separating liquid in the above (2), rinse the resin 4BV with acid water with a pH value of 2, and then use 0.06% NaHCO 3 Wash 8BV of the solution, collect the lye, and adjust the pH value to 3.

[0029] (4) Resin separation: wash the separation solution in the above (3) with 4BV of acid water with a pH value of 1 to 2, then add AB-8 resin, the sample volume is 8BV, and the...

Embodiment 3

[0033] (1) Acid extraction: take 800 g of dried forsythia medicinal material, soak it in 15 times the amount of acidic water with a pH value of 1.5 for 8 times, each time for 24 hours, filter with a 200-mesh filter cloth, and combine the filtrates.

[0034] (2) Resin separation: the above-mentioned filtrate was rinsed with acid water with a pH value of 1.5 for 3BV of the resin, and then separated with AB-8 resin. Rinse 4BV with 40% ethanol, collect the eluent, dry under reduced pressure at 60°C until no alcohol, and adjust the pH to 2.

[0035] (3) Polyamide separation: put 100-200 mesh polyamide on the separating liquid in the above (2), rinse the resin 3BV with acid water with a pH value of 1.5, and then use 0.06% NaHCO 3 Wash 6BV of the solution, collect the lye, and adjust the pH value to 2.

[0036] (4) Resin separation: The separation liquid in the above (3) is first rinsed with acid water with a pH value of 1 to 2 for 3BV of the resin, then loaded with AB-8 resin, and ...

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Abstract

The invention discloses a preparation method for forsythoside A. The preparation method for the forsythoside A comprises the following steps of: (1) immersing raw material medicament in acid, and extracting; (2) separating by using resin; (3) separating by using polyamide; (4) separating by using resin; (5) purifying by using reverse phase silica gel; and (6) purifying by using dextrangel. According to the method, an alcohol-water system is used for extraction and separation, and resin materials used in the process are recycled, so the production cost is reduced. By the extraction method of the preparation method for the forsythoside A, the content of the final product forsythoside A is up to 90 to 95 percent; therefore, the process is simple and efficient, and is suitable for industrial production.

Description

technical field [0001] The invention relates to a method for extracting traditional Chinese medicine, in particular to a method for preparing forsythiaside A, which belongs to the field of medicine. Background technique [0002] Forsythia is a deciduous shrub of Forsythiaceae Oleaceae. Its fruit can be used as medicine, which has the functions of clearing away heat and detoxification, dispelling stagnation and reducing swelling, and resisting bacteria and fungi. Forsythiaside A is the main component of forsythia, not only has inhibitory effect on Staphylococcus aureus and other pathogenic bacteria, but also can inhibit phosphodiesterase, fungus and active oxygen, so it is used in natural preservatives and natural The field of antioxidants has a wide range of application prospects. [0003] At present, the extraction and separation methods of forsythiaside A have been reported in various literatures. The method adopted in the prior art directly extracts with water or extrac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/18C07H1/08
Inventor 胡晨旭魏峰周水平
Owner TIANJIN TASLY PHARMA CO LTD
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