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Ketoprofen gel and preparation method thereof

A ketoprofen and gel technology, applied in the field of ketoprofen gel preparation and its preparation, can solve the problems of low viscosity and the like, and achieve the effects of easy storage, remarkable therapeutic effect and good transdermal absorption

Inactive Publication Date: 2011-05-25
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Carbomer is a high-molecular polymer cross-linked with acrylic acid and propylene-based sucrose. It is a white, loose, acidic, hygroscopic powder with a slight special odor. Because the molecule contains a large number of shuttle groups, it is hydrophilic and can be dissolved in water. Rapidly swells, but does not dissolve, low viscosity

Method used

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  • Ketoprofen gel and preparation method thereof
  • Ketoprofen gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Preparation formula: ketoprofen 2.5g; absolute ethanol 947.5g; polyethylene glycol PEG400 3000g; propylene glycol 1000g; carbomer 940NF 50g; triethanolamine 5% ethanol solution 10ml.

[0012] Preparation method: Weigh 2.5g of ketoprofen and add 947.5g of absolute ethanol to dissolve into ketoprofen ethanol solution for later use; take 50g of Carbomer 940NF, add 3000g of polyethylene glycol PEG400 and 1000g of propylene glycol, heat at 70-80°C and stir to disperse evenly , then dropwise add 10ml of triethanolamine 5% ethanol solution to adjust the pH value to 4.6), after stirring evenly, a transparent gel matrix can be obtained; After stirring evenly, 5000 g of ketoprofen gel can be made, sterilized, rapidly cooled, condensed, and dried to obtain final product.

Embodiment 2

[0014] Preparation formula: ketoprofen 2.5g; absolute ethanol 947.5g; polyethylene glycol PEG400 3000g; propylene glycol 1000g; carbomer 940NF 50g; triethanolamine 5% ethanol solution 10ml.

[0015] Preparation method: Weigh 0.25g of ketoprofen and add 200g of absolute ethanol to dissolve into ketoprofen ethanol solution for later use; take 10g of Carbomer 940NF, add 580g of polyethylene glycol PEG400 and 207.5g of propylene glycol, heat at 70-80°C and stir to disperse evenly , then dropwise add 20ml of triethanolamine 5% ethanol solution (adjust the pH value to 4.2), and get a transparent gel matrix through stirring; gradually add the above-mentioned standby ketoprofen ethanol solution into the gel matrix , can be made into 1000g of ketoprofen gel after stirring evenly, sterilize, cool down rapidly, condense, and dry to get final product.

Embodiment 3

[0016] Embodiment 3 ketoprofen gel preliminary stability test

[0017] pH measurement: prepare 3 batches of samples with the best prescription, take 2g each in a small beaker, add 50ml of distilled water to prepare a uniform solution, and measure the pH with a pHS-2C acidity meter.

[0018] Centrifugal test: prepare 3 batches of samples with the best prescription, take 5g each, put them in a 10ml centrifuge tube, centrifuge (3000r / min) for 30min, observe the changes in the appearance and spreadability of the gel.

[0019] Heat resistance test: Prepare 3 batches of samples with the best prescription, place them in glass bottles and seal them, put them in an oven at (60±2)°C, take them out after 24 hours, return to room temperature, observe the changes in appearance, spreadability and pH, and Determination of content.

[0020] Cold resistance test: Prepare 3 batches of samples with the best prescription, put them in a glass bottle and seal them, put them in a refrigerator at (-...

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Abstract

The invention discloses ketoprofen gel and a preparation method thereof, and the ketoprofen gel can be obtained by adding ketoprofen ethanol solution prepared by ketoprofen and anhydrous ethyl alcohol into a gel matrix prepared by polyethylene glycol PEG400, propylene glycol and carbopol 940NF and uniformly stirring, wherein the ketoprofen gel comprises the following raw materials by weight percent: 0.02-0.08% of ketoprofen, 15-40% of anhydrous ethyl alcohol, 40-80% of polyethylene glycol PEG400, 10-30% of propylene glycol and 0.5-2% of carbopol 940NF. The ketoprofen gel has the advantages that the stability is much better than ingredients, the storage is easy, and the ketoprofen gel is less prone to volatilization. Experimental results about the stability prove that the quality of the ketoprofen gel is more stable, and various indicators have no significant changes.

Description

field of invention [0001] The invention relates to a ketoprofen gel preparation and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] Ketoprofen is a non-steroidal anti-inflammatory drug (NSAI) with anti-inflammatory, antipyretic, and analgesic properties. Topical pharmaceutical formulations of ketoprofen and dexketoprofen are described in most scientific literature as irritants, Allergens, phototoxins and photoallergens. Ketoprofen is similar to other non-steroidal anti-inflammatory drugs, and has serious adverse reactions during clinical application, such as: ①digestive system symptoms such as stomach discomfort, stomach pain, heating, and diarrhea; ②allergic symptoms such as eruption and rash, ③ Major adverse reactions such as acute renal insufficiency, liver dysfunction, and peptic ulcer may occur. According to the characteristics that ketoprofen is mainly used to treat chronic rheumatoid arthritis, osteoarthriti...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/192A61K47/34A61P29/00A61K47/10A61K47/32
Inventor 颜范勇陈莉刘冬青俞秋华曹冬磊代林枫
Owner TIANJIN POLYTECHNIC UNIV
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