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Method for extracting quebrachitol from sapindaceae plant lychee and longan

A technology of Quina bark alcohol and Sapindaceae, which is applied in the field of separation and extraction of natural compounds, can solve the problems of high cost, complex production process, and extraction of Quina bark alcohol, etc., to reduce production costs, simplify process conditions, and operate easy effect

Inactive Publication Date: 2011-06-15
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] To sum up, for a long time, the preparation source of Quina Cortisol is relatively single; and the production process is complicated and costly, which directly affects the wide application of Quina Cortitol.
However, there is no report on extracting Quaja cortisol from litchi and longan

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) 100g black leaf lychee peel dry powder (20 mesh) + 400ml 75% (w / w) ethanol (three times), ultrasonic extraction at 70°C for 1.5 hours each, combined filtrate, concentrated by rotary evaporation under reduced pressure at 60°C to To about 50ml, add 50ml of distilled water and mix well, then add 200ml of ethyl acetate in a separatory funnel, mix well, save the water phase for later use; add 200ml of ethanol to the water phase, 80 ° C water bath, mix well, add 30g of activated carbon 1 Filtrate after 1 hour, concentrate the filtrate to about 50ml by rotary evaporation under reduced pressure at 60°C, add 100ml of ethanol, dissolve in a water bath at 80°C and let it stand for 1 hour, cool at -5°C, filter to obtain crystals, dry at 100°C, and obtain 1.51g of quebracho bark Crude alcohol; add 8ml of distilled water to the crude product to dissolve at 80oC for 30 minutes, add 20ml of ethanol, keep warm for 30 minutes, cool at -5°C, collect crystals by filtration, repeat 3 tim...

Embodiment 2

[0027] (2) 100g black leaf lychee peel dry powder (20 mesh) + 600ml 90% (w / w) ethanol (three times), ultrasonic extraction at 80°C for 2 hours each, the combined filtrate, and the filtrate was concentrated by rotary evaporation under reduced pressure at 60°C to obtain To about 50ml, add 50ml of distilled water and mix well, then add 300ml of ethyl acetate in a separatory funnel, mix well, save the water phase for later use; add 200ml of ethanol to the water phase, 80°C water bath, mix well and add 30g of activated carbon 1 Filtrate after 1 hour, concentrate the filtrate to about 50ml by rotary evaporation under reduced pressure at 60°C, add 100ml of ethanol, dissolve in a water bath at 80°C and let it stand for 1 hour, cool at -5°C, filter to obtain crystals, dry at 100°C, and obtain 1.75g ​​of quebracho bark Crude alcohol; add 8ml of distilled water to the crude product to dissolve at 80oC for 30 minutes, add 20ml of ethanol, incubate for 30 minutes and cool at -5℃, collect cr...

Embodiment 3

[0029] (3) 100g black leaf lychee seed dry powder (20 mesh) + 600ml 90% (w / w) ethanol (divided into three times), 80 ℃ ultrasonic extraction for 2 hours each, the combined filtrate, and the filtrate was concentrated by rotary evaporation under reduced pressure at 60 ℃ to obtain To about 50ml, add 50ml of distilled water and mix well, then add 300ml of petroleum ether in a separatory funnel, mix well, save the water phase for later use; add 200ml of ethanol to the water phase, 80°C water bath, mix well, add 30g of activated carbon for 1 hour After filtration, the filtrate was concentrated to about 50ml by rotary evaporation under reduced pressure at 60°C, added 100ml of ethanol, dissolved in a water bath at 80°C and left for 1 hour, cooled at -5°C, filtered to obtain crystals, dried at 100°C, and 1.62g of Quaia bark alcohol was obtained Crude product; add 8ml of distilled water to the crude product to dissolve at 80oC for 30 minutes, add 20ml of ethanol, incubate for 30 minutes ...

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PUM

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Abstract

The invention discloses a method for extracting quebrachitol from sapindaceae plant lychee or longan. The method comprises the following steps of: performing reflux extraction by using 60 to 90 percent hot ethanol; extracting and purifying with ethyl acetate; de-coloring with active carbon; and crystallizing. Main raw materials are peels, kernels or leaves of lychee or longan. Compared with the prior art, the method has the advantages of low in raw material cost, readily available raw materials, simple and reliable process, high product yield and purity, low production cost and the like, and is particularly suitable for mass industrial production.

Description

technical field [0001] The invention belongs to the technical field of separation and extraction of natural compounds, and in particular relates to a method for extracting quebranol from Sapindaceae plant litchi or longan. Background technique [0002] Quebrachitol, named after Quebracho, was first isolated from the bark extract of Quebracho used by South American residents to treat diseases. Quina cortisol is a medicinal natural compound with optical activity. At present, the Brazilian rubber latex has been successfully used to extract the optically active natural product quebranol as a plant drug raw material for the pharmaceutical industry to easily and conveniently synthesize non-toxic, harmless and effective chiral drugs for the treatment of cancer and premature aging diseases such as dementia, diabetes and AIDS. Relevant literature research shows that U.S. Patent No. 72809 discloses a method for extracting quebracho cortex from natural rubber whey (U.S. 1925), using ...

Claims

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Application Information

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IPC IPC(8): C07C43/196C07C41/34
Inventor 王惠聪黄旭明陈厚彬胡桂兵
Owner SOUTH CHINA AGRI UNIV
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