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Plant extract composition for preventing and treating lipidmetabolic disorder and preparation method thereof

A technology of plant extracts and lipid metabolism disorders, applied in drug combinations, metabolic diseases, plant raw materials, etc., can solve the problems that affect the stability of the clinical efficacy of the product, the compliance of patients is not ideal, and the active ingredients cannot be purified. , achieve safety without obvious side effects, controllable product quality, reduce the effect of preparation quality and safety

Active Publication Date: 2013-11-13
QINGDAO BAILI CAIXIN MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although many compound Chinese medicines have good blood lipid regulation function and clinical curative effect, they still have many deficiencies because they are compound Chinese medicine preparations: (1) Their ingredients are complex, and their active ingredients are not clear and difficult to quantify, which will eventually affect The stability of the clinical curative effect of the product, (2) relatively simple preparation process, the active ingredients in the prescription cannot be properly purified, there are many impurities, the dosage is large, and the patient's compliance is not ideal, (3) due to the extraction of the prescription The volume is large, and the scope of application is subject to various restrictions

Method used

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  • Plant extract composition for preventing and treating lipidmetabolic disorder and preparation method thereof
  • Plant extract composition for preventing and treating lipidmetabolic disorder and preparation method thereof
  • Plant extract composition for preventing and treating lipidmetabolic disorder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of embodiment 1 SHCE

[0036] One, the preparation of Panax notoginseng total saponins extract

[0037] (1) Panax notoginseng saponins extract

[0038]Weigh 10 kg of Panax notoginseng medicinal material, pulverize it, and reflux extraction with 75% ethanol of 8 times, 8 times and 6 times the amount of the medicinal material, respectively, for 3 times, 2 hours each time, and filter the combined extracts with a 200-mesh filter cloth, and combine the filtrates. Recover the ethanol and make the concentration of the ethanol extraction part 1ml equivalent to 1g crude drug concentrate (1.9 L); absorb on a macroporous resin column, the macroporous resin is HPD-100 of the polystyrene weakly basic anion exchange resin series, press 1 Add 1.5L of concentrated solution to a macroporous resin column for adsorption on kg resin, wash with water until the eluate is nearly colorless, then elute with 4.5 L of 85% ethanol at a flow rate of 10 ml / min, and elute until t...

Embodiment 2

[0083] Example 2 Effect of SHCE on gene expression and activity of key enzymes in blood lipid metabolism

[0084] 1.1 Effects on gene expression and activity of hepatic lipase (HL) enzyme and cholesterol 7-α-hydroxylase (CYP7A1) in hepatocytes

[0085] Cultivate L-O2 human normal liver cells according to the routine. After the cells are fused, add various concentrations of SHCE and FTZ. After continuing to cultivate for a certain period of time, collect the cells to make a cell homogenate, use the HL detection kit, and use the colorimetric method The enzyme activities of HL and CYP7A1 were detected, the effects of the above-mentioned different concentrations of SHCE on the enzyme activities of HL and CYP7A1 were studied, and the enzyme activities of HL and CYP7A1 in liver cells under the action of different concentrations of SHCE were compared. In addition, total RNA in hepatocytes was extracted with Trizol reagent, and the expression of CYP7A1 and HL enzyme genes in hepatoc...

Embodiment 3

[0101] Example 3 Effect of SHCE on Experimental Rat Hyperlipidemia

[0102] Experimental animals: SD rats, SPF grade, male, body weight 200±20 g.

[0103] Experimental method: After one week of adaptive feeding, the rats were randomly divided into normal control group and model-making group according to body weight, of which 10 in the normal control group were fed with basic feed; 80 in the model-making group were fed with high-fat feed for 2 weeks, Orbital blood was taken to measure blood lipids, and those with significantly higher blood lipids were selected as rats with successful hyperlipidemia modeling.

[0104] Those whose blood TC value was higher than 2.5mmol / L were included in the experiment, and hyperlipidemia rats were divided into hyperlipidemia model group, each extract group and positive drug simvastatin (20mg / kg body weight·d) group according to the blood lipid level. Group 10. The normal control group and the hyperlipidemia model group were given equal volum...

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Abstract

A plant extract composition used for preventing and treating lipid metabolism disorder, comprising total Radix Notoginseng saponin extract and total Rhizoma Coptidis alkaloid extract. The preparative method of the composition comprises: extracting Radix Notoginseng with C1-3 alcohol, combining extracts and concentrating to obtain concentrated liquid, removing non-saponin component from the concentrated liquid to obtain total Radix Notoginseng saponin extract; adding C1-3 alcohol into Rhizoma Coptidis, refluxing and extracting, retrieving C1-3 alcohol, concentrating to obtain concentrated liquid, dissolving the concentrated liquid in acid, and performing alkali precipitation and recrystallization to obtain total Rhizoma Coptidis alkaloid extract; mixing the total Radix Notoginseng saponin extract and the total Rhizoma Coptidis alkaloid extract to obtain the composition.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract composition, in particular to a plant extract composition for preventing and treating lipid metabolism disorder and a preparation method thereof. Background technique [0002] "Fufang Zhenzhu Tiaozhi Fang" (FTZ), a traditional Chinese medicine composition, is used to treat hyperlipidemia and has achieved ideal curative effect, with a total clinical effective rate of 91%. The whole prescription is composed of 8 traditional Chinese medicines including Ligustrum lucidum, Atractylodes macrocephala, Bergamot, Eucommia, Daji, Salvia miltiorrhiza, Coptis chinensis, and Panax notoginseng. The group FTZ has been authorized by the national invention patent, patent number: 200410051250.4. [0003] Although many compound Chinese medicines have good blood lipid regulation function and clinical curative effect, they still have many deficiencies because they are compound Chinese medicine preparations: (...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61P3/00A61P3/06
CPCA61K2236/00A61K36/718A61K36/258A61P3/00A61P3/06A61K2300/00
Inventor 郭姣
Owner QINGDAO BAILI CAIXIN MEDICAL TECH CO LTD
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