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Bombax malabaricum DC. leaf total phenol extract and preparation method thereof, and application of extract in treatment of type-2 diabetes mellitus

A type 2 diabetes mellitus and extract technology, applied in the field of kapok leaf total phenolic extract, can solve the problems of high price of insulin preparations, large toxic and side effects, aggravated cardiovascular complications, etc., and achieve the effect of excellent hypoglycemic effect

Active Publication Date: 2012-07-04
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Insulin preparations are expensive and difficult to popularize; although chemical drugs have obvious hypoglycemic effects, they have relatively toxic side effects on the liver and kidneys, and can easily lead to aggravation of cardiovascular complications, etc.
Although Chinese patent medicines have a certain therapeutic effect, there is currently no modern Chinese medicine with significant efficacy, clear active ingredients and mechanism of action, controllable quality, and advanced preparations.

Method used

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  • Bombax malabaricum DC. leaf total phenol extract and preparation method thereof, and application of extract in treatment of type-2 diabetes mellitus
  • Bombax malabaricum DC. leaf total phenol extract and preparation method thereof, and application of extract in treatment of type-2 diabetes mellitus
  • Bombax malabaricum DC. leaf total phenol extract and preparation method thereof, and application of extract in treatment of type-2 diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Get 50kg of kapok leaves, use 60% ethanol 12 times of the weight of the material, and heat reflux to extract three times, each time for 2 hours. After the extract was concentrated, it was allowed to stand overnight and filtered, and the residue was 5.4 kg of total phenolic extract of kapok leaves.

Embodiment 2

[0070] Take 50 kg of kapok leaves, extract with 70% ethanol which is 15 times the weight of the material, and extract under reflux three times, each time for 1 hour. After the extract is concentrated, put it on the AB-8 macroporous resin column, first use 4 times the amount of water to elute to remove impurities, then use 7 times the amount of 30% ethanol to elute, collect the eluate, and concentrate to obtain the total phenolic extract of kapok leaf 4.7 kg.

Embodiment 3

[0072] Take 400 mg of the extract prepared by the method in Example 2 and 200 mg of micropowder silica gel, pass through a 60-mesh sieve and mix thoroughly, add an appropriate amount of magnesium stearate to mix, and dry granulate. Pass through a 40-mesh sieve and fill into capsules.

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Abstract

The invention relates to the field of natural medicines, in particular to bombax malabaricum DC. leaf total phenol extract and a preparation method thereof. The extract can prevent or treat type-2 diabetes mellitus. The preparation method is characterized by comprising the following steps of: extracting the extract from bombax malabaricum DC. leaves by using a polar solvent, concentrating and drying. A pharmacological test proves that the bombax malabaricum DC. leaf total phenol extract has the effect of preventing or treating the type-2 diabetes mellitus.

Description

technical field [0001] The invention relates to the field of natural medicines, in particular to a kapok leaf total phenol extract, which can prevent or treat type 2 diabetes. Background technique [0002] Diabetes mellitus is caused by genetic factors, immune dysfunction, microbial infection and its toxins, free radical toxins, mental factors and other pathogenic factors acting on the body, resulting in decreased islet function, insulin resistance (Insulin Resistance, IR), etc. And a series of metabolic disorder syndromes such as sugar, protein, fat, water and electrolytes caused. At present, my country has become one of the countries with the fastest growing prevalence of diabetes in the world. According to the 2002 National Nutrition and Health Survey, there are more than 20 million diabetics in my country, and nearly 20 million people with impaired glucose tolerance. In 2007, there were 39.81 million diabetic patients in mainland China (excluding Hong Kong, Macao, and T...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P3/10A61K127/00
Inventor 秦民坚王国凯刘保林刘欣欣吴刚林彬彬洪俊丽王琦秦晓颖
Owner CHINA PHARM UNIV