Easy-dissolution lamivudine tablet and preparation method thereof

A technology of lamivudine tablets and lamivudine, which is applied in pill delivery, digestive system, antiviral agents, etc., can solve the problems of differences in bioavailability and drug dissolution, and achieve high dissolution and bioavailability The effect of high precision and simple process

Active Publication Date: 2012-11-28
FUJIAN COSUNTER PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Different preparation methods of the same pharmaceutical preparation may have significant differences in the dissolution rate of the drug, so that the bioavailability may also have significant differences. The same pharmaceutical preparation may have higher biological activity using some preparation methods than other preparation methods

Method used

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  • Easy-dissolution lamivudine tablet and preparation method thereof
  • Easy-dissolution lamivudine tablet and preparation method thereof
  • Easy-dissolution lamivudine tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Get lamivudine 100g, microcrystalline cellulose 100g, sodium carboxymethyl starch 6.5g, magnesium stearate 2.1g, 2% hydroxypropylmethylcellulose (E15) aqueous solution 105g.

[0031] The preparation method of lamivudine tablet comprises the following processing steps:

[0032] (1) take above-mentioned parts by weight lamivudine, microcrystalline cellulose, sodium carboxymethyl starch, magnesium stearate and cross 100 mesh sieves;

[0033] (2) Weigh hydroxypropyl methylcellulose, add purified water (mass ratio 2: 98) and stir to make the hydroxypropyl methylcellulose mixed pulp of the above-mentioned 2% by weight:

[0034] (3) The sodium carboxymethyl starch and the microcrystalline cellulose are uniformly mixed by equal addition method, and then the lamivudine is mixed with it.

[0035] (4) Add the prepared 2% hydroxypropyl methylcellulose mixed pulp as a binder and add to step (3) to make a soft material, pass through a 24-mesh sieve for granulation. Place in an oven...

Embodiment 2

[0040] Take lamivudine 100g, microcrystalline cellulose 95g, sodium carboxymethyl starch 5g, magnesium stearate 1.5g, 2% hydroxypropylmethylcellulose (E15) aqueous solution 90g. 1000 lamivudine tablets can be produced, each containing 100 mg of active ingredient lamivudine.

[0041] All the other are with embodiment 1.

Embodiment 3

[0043] Get lamivudine 100g, microcrystalline cellulose 105g, sodium carboxymethyl starch 8g, magnesium stearate 3g, 2% hydroxypropylmethylcellulose (E15) aqueous solution 120g. 1000 lamivudine tablets can be produced, each containing 100 mg of active ingredient lamivudine.

[0044] All the other are with embodiment 1.

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Abstract

The invention relates to an easy-dissolution lamivudine tablet and a preparation method thereof. The lamivudine tablet comprises the following raw materials in parts by weight: 100 parts of lamivudine, 95-105 parts of microcrystalline cellulose, 5-8 parts of sodium carboxymethyl starch, 1.5-3 parts of magnesium stearate and 90-120 parts of 2% hydroxypropyl methylcellulose (E15) aqueous solution.

Description

technical field [0001] The invention relates to a lamivudine tablet which is easy to dissolve and a preparation method thereof. Background technique [0002] Lamivudine is a deoxycytidine analog with the chemical name (2R,5S)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolane -5-yl)-(1H)-pyrimidin-2-one. [0003] Its molecular structural formula is as follows: [0004] [0005] Molecular formula: C 8 h 11 N 3 o 3 S. [0006] Lamivudine is a nucleoside antiviral drug, which has a strong inhibitory effect on hepatitis B virus (HBV) in vitro and in experimentally infected animals. Lamivudine can be metabolized into active form lamivudine triphosphate in HBV-infected cells and normal cells, which is not only an inhibitor of HBV polymerase, but also a substrate of this polymerase. Lamivudine triphosphate penetrates into the viral DNA strand and blocks the synthesis of viral DNA. The results of serum HBV DNA detection in most patients with hepatitis B showed that lamivudine ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/513A61K47/38A61P1/16A61P31/20
Inventor 李国栋陈国华
Owner FUJIAN COSUNTER PHARMA CO LTD
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