The present invention relates to a synthesis device of 4-chloroacetoacetate. The synthesis device comprises a reactor, a reactor, a material storage device, a material discharging pipe and two material feeding pipes, and the reactor comprises a side wall, an end wall and a cavity formed through surrounding; the material storage device is arranged in a cavity of the reactor and comprises a side wall, an end wall and a cavity formed through surrounding, and a plurality of through holes are formed in the side wall; the first feeding pipe is communicated with the cavity of the reactor, and the second feeding pipe is communicated with the cavity of the material storage device; and the discharge pipe is communicated with the cavity of the reactor. During reaction, gas can generate a large numberof bubbles through the through holes, the bubbles can generate a vortex stirring effect, and the gas can quickly react with diketene so that the reaction rate is increased, the reaction time is shortened, the production efficiency is improved, and meanwhile, the generation of a byproduct 2-chloroacetoacetate is reduced.