A kind of Zidolamid bisvudine tablet that is easy to dissolve and preparation method thereof

A lamivudine and low-substitution technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve problems such as differences in drug dissolution and bioavailability, and achieve The effect of high dissolution rate, high bioavailability and simple process

Active Publication Date: 2016-05-11
ANHUI BIOCHEM BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Different preparation methods of the same pharmaceutical preparation may have significant differences in drug dissolution rate, resulting in great differences in bioavailability. For the dosage form of the same drug, some preparation methods may have higher efficacy than other preparation methods. biological activity

Method used

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  • A kind of Zidolamid bisvudine tablet that is easy to dissolve and preparation method thereof
  • A kind of Zidolamid bisvudine tablet that is easy to dissolve and preparation method thereof
  • A kind of Zidolamid bisvudine tablet that is easy to dissolve and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 300g of zidovudine, 150g of lamivudine, 40g of lactose, 60g of microcrystalline cellulose, 6g of magnesium stearate, 160g of 3% low-substituted hydroxypropyl cellulose mixed solution

[0030] The preparation method of zidolamidivudine tablet comprises the following processing steps:

[0031] (1) Accurately weigh zidovudine, lamivudine, lactose, microcrystalline cellulose, magnesium stearate and pass through 80 mesh or 100 mesh sieve respectively of above-mentioned weight portion;

[0032] (2) Accurately weigh the low-substituted hydroxypropyl cellulose, add purified water, the mass ratio of the two is 3:97, stir well to make the above-mentioned 3% low-substituted hydroxypropyl cellulose mixed solution by weight;

[0033] (3) mix zidovudine, lamivudine, lactose, microcrystalline cellulose evenly;

[0034] (4) Then add the prepared 3% low-substituted hydroxypropyl cellulose mixture into step (3) to make a soft material and granulate it through a 20-30 mesh screen, ...

Embodiment 2

[0039] Weigh 300g of zidovudine, 150g of lamivudine, 50g of lactose, 50g of microcrystalline cellulose, 6g of magnesium stearate, 170g of 3% low-substituted hydroxypropyl cellulose mixed solution

[0040] All the other are the same as embodiment 1

Embodiment 3

[0042] Weigh 300g of zidovudine, 150g of lamivudine, 60g of lactose, 60g of microcrystalline cellulose, 8g of magnesium stearate, 155g of 3% low-substituted hydroxypropyl cellulose mixed solution

[0043] All the other are the same as embodiment 1

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Abstract

The invention relates to a zidovudine-lamivudine tablet easy to dissolve out and a preparation method thereof. The zidovudine-lamivudine tablet comprises the following raw materials in parts by weight: 300 parts of zidovudine, 150 parts of lamivudine, 40-60 parts of lactose, 40-60 parts of microcrystalline cellulose, 155-170 parts of a 3% low substituted hydroxypropyl cellulose aqueous solution, and 6-8 parts of magnesium stearate.

Description

technical field [0001] The present invention relates to a zidolamid bisvudine tablet which is easy to dissolve and a preparation method thereof Background technique [0002] Zidovudine is used for the treatment of AIDS or AIDS-related syndrome patients and immunodeficiency virus (HIV) infection. Zidovudine is the world's first drug approved by the U.S. Food and Drug Administration on March 19, 1987. An anti-AIDS drug has become the most basic component of the "cocktail" therapy because of its definite curative effect. This product is highly active against retroviruses including human immunodeficiency virus (HIV) in vitro. In virus-infected cells, it is phosphorylated by cellular thymidine kinase to zidovudine triphosphate, which selectively inhibits HIV reverse enzyme, leading to the termination of HIV chain synthesis and preventing HIV replication. The Zidovudine structure used in the present invention is as follows: [0003] [0004] Lamivudine is a nucleoside antivi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7072A61K31/513A61K9/20A61K47/38A61K47/26A61P31/18
Inventor 沈蔡月朱礼根
Owner ANHUI BIOCHEM BIO PHARMA
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