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Method for preparing nanogate carbon suspension

A suspension and nano-carbon technology, which is applied in the field of medical tracer diagnostic reagent preparation, can solve the problems of high requirements on machinery and equipment, difficult removal of oxidants, residual oxidants, etc., and achieves short production time, shortened preparation time, and safe and practical products. Effect

Inactive Publication Date: 2011-08-10
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The grinding method usually takes a long time and has high requirements on the machinery and equipment, which seriously affects the production efficiency
Oxidation methods usually have the problem of oxidant residues. In order to make the oxidation effect complete, more oxidants are usually added. Due to the strong adsorption capacity of activated carbon itself, it is difficult to completely remove the oxidants after the reaction. During use, there may be cause harm to the user

Method used

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  • Method for preparing nanogate carbon suspension
  • Method for preparing nanogate carbon suspension
  • Method for preparing nanogate carbon suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Accurately weigh 100 g of Mitsubishi Carbon Black MA100 and 10 g of shellac, disperse them in 1000 ml of distilled water, stir with a glass rod for 5 minutes, ultrasonicate for 30 minutes, fully disperse, and then spray dry.

[0043] The parameters of spray drying are: inlet temperature is 120°C, outlet temperature is 45°C, sample injection speed is 8ml / min, atomization pressure is 120Kpa, and wind speed is 0.8m3 / min.

[0044] Weigh 8.000g NaCl, 0.350g NaHCO 3 , Dissolve 0.224g KCl in 1000ml distilled water to make isotonic solution for human body. Flush the sample collector of the spray dryer with the above human body isotonic solution to obtain a nano-carbon suspension, and adjust the pH value to 7.0 with sodium dihydrogen phosphate. The average particle diameter measured and calculated by X-ray diffraction method is 120nm. see Figure 4 .

Embodiment 2

[0046] Accurately weigh 200g of Mitsubishi Carbon Black MA100 and 15g of PEG 4000, disperse them in 1000ml of distilled water, stir with a glass rod for 5 minutes, ultrasonicate for 2 hours, fully disperse, and then spray dry.

[0047] The parameters of spray drying are: the inlet temperature is 100°C, the outlet temperature is 50°C, the injection speed is 10ml / min, the atomization pressure is 150Kpa, and the wind speed is 1m 3 / min.

[0048] Weigh 8.000g NaCl, 0.350g NaHCO 3, Dissolve 0.224g KCl in 1000ml distilled water to make isotonic solution for human body. The sample collector of the spray dryer was flushed with the above isotonic solution of human body to obtain a nano-carbon suspension, and the pH value was adjusted to 7.0 with sodium citrate. The average particle diameter measured by X-ray diffraction method is 136nm. see Figure 5 .

Embodiment 3

[0050] Accurately weigh 50g of Mitsubishi carbon black MA100 and 1g of polyvinylpyrrolidone, disperse them in 1000ml of distilled water, stir with a glass rod for 5 minutes, ultrasonicate for 30 minutes, fully disperse, and then spray dry.

[0051] The parameters of spray drying are: the inlet temperature is 145°C, the outlet temperature is 65°C, the injection speed is 12ml / min, the atomization pressure is 160Kpa, and the wind speed is 1.2m 3 / min.

[0052] Weigh 8.000g NaCl, 0.350g NaHCO 3 , Dissolve 0.224g KCl in 1000ml distilled water to make isotonic solution for human body. Flush the sample collector of the spray dryer with the above human body isotonic solution to obtain a nano-carbon suspension, and adjust the pH value to 7.0 with sodium hydroxide. The average particle diameter measured by a laser particle size analyzer is 130 nm.

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Abstract

The invention relates to a method for preparing nanogate carbon suspension, belonging to the field of medical tracer diagnostic reagents. The method comprises the following steps of: preparing the nanogate carbon suspension by adopting a spraying pyrolysis method; washing carbon black with acid and base to remove an inorganic impurity and organically washing to remove oil-soluble impurities; dissolving the washed carbon balck together with a dispersion agent into water; carrying out stirring, ultrasonic dispersion and spray drying, wherein in the process of spray drying, the carbon black is decomposed under the actions of high temperature and high pressure to form nanogate carbon particles with the particle size within 100 to 200nm; and finally, dissolving with an isotonic solution for a human body to obtain the nanogate carbon suspension and adjusting the pH value of the suspension to be neutral by using a pH adjuster. The nanogate carbon suspension has stable property and strong coloring power for mouse lymph and can completely meet the medical requirement. In addition, the method adopts a simple preparation process, has low production cost and wide market prospect and is suitable for industrial production; and the preparation time of the nanogate carbon suspension is greatly shortened.

Description

technical field [0001] The invention relates to a method for preparing a nano-carbon suspension, which is an improvement on the existing preparation process of the nano-carbon suspension, and belongs to the technical field of preparation of medical tracer diagnostic reagents. Background technique [0002] In the field of medical technology, lymphatic metastasis of cancer cells means that malignant tumor cells break away from their original site and spread to other parts of the body through direct spread, lymphatic channels, blood channels and planting, and even continue to proliferate and grow in multiple organs. form tumors of the same nature. Lymphatic metastasis often occurs in advanced cancer patients. Lymphatic metastasis is one of the important factors affecting the prognosis of malignant tumors. The fate of many tumor patients is often not determined by the primary tumor. Therefore, effectively dissecting lymph nodes in the tumor drainage area is an important means ...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K47/04
Inventor 刘小波滕利荣孟庆繁逯家辉沈畏王贞佐程瑛琨金叶滕乐生孟令军
Owner JILIN UNIV
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