Method for modifying nano hydroxyapatite, nano hydroxyapatite/polylactic acid compound material and preparation method of nano hydroxyapatite/polylactic acid compound material

A nano-hydroxyapatite and composite material technology, applied in the field of composite materials, can solve the problems of high reaction temperature, reduced hydroxyapatite purity, high equipment and process requirements, achieve good dispersion performance, improve interface compatibility, The effect of short process cycle

Active Publication Date: 2013-03-06
CHANGCHUN SINOBIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in this method, lactic acid will partially decompose hydroxyapatite to generate calcium lactate as a by-product, which reduces the purity of hydroxyapatite; in addition, this method requires a higher reaction temperature and requires higher equipment and process requirements.

Method used

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  • Method for modifying nano hydroxyapatite, nano hydroxyapatite/polylactic acid compound material and preparation method of nano hydroxyapatite/polylactic acid compound material
  • Method for modifying nano hydroxyapatite, nano hydroxyapatite/polylactic acid compound material and preparation method of nano hydroxyapatite/polylactic acid compound material
  • Method for modifying nano hydroxyapatite, nano hydroxyapatite/polylactic acid compound material and preparation method of nano hydroxyapatite/polylactic acid compound material

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Experimental program
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Effect test

Embodiment 1

[0063] The modification of embodiment 1 nano-hydroxyapatite

[0064] 20g of oligomeric lactic acid with a number average molecular weight of 600 is heated and dissolved in 300mL of acetone to obtain a oligomeric lactic acid acetone solution; 75g of nano-hydroxyapatite hydrosol is added to the oligomeric lactic acid-acetone solution, and the nano-hydroxyapatite The mass of water in the hydrosol is 2.5 times the mass of nano-hydroxyapatite. After ultrasonic treatment for 40 minutes, add 300 mL of distilled water. After filtration, the obtained filtrate is dried under reduced pressure at 40°C for 72 hours to obtain nano-hydroxyapatite and oligomeric a mixture of lactic acids;

[0065] Dissolve the mixture of nano-hydroxyapatite and oligomeric lactic acid in 100 mL of chloroform, sonicate for 15 minutes, then centrifuge at high speed for 15 minutes, repeat the operation 3 times to remove excess oligomeric lactic acid, and dry under reduced pressure at 40°C for 72 hours to obtain o...

Embodiment 2

[0071] Modification of embodiment 2 nanometer hydroxyapatite

[0072] 20g of oligomeric lactic acid with a number average molecular weight of 2300 is heated and dissolved in 300mL of acetone to obtain a oligomeric lactic acid acetone solution; 75g of nano-hydroxyapatite hydrosol is added to the oligomeric lactic acid-acetone solution, and the nano-hydroxyapatite The mass of water in the hydrosol is 2.5 times the mass of nano-hydroxyapatite. After ultrasonic treatment for 40 minutes, 300 mL of distilled water is added, and after filtration, the obtained filtrate is dried under reduced pressure at 60°C for 72 hours to obtain nano-hydroxyapatite and oligomers. a mixture of lactic acids;

[0073] Dissolve the mixture of nano-hydroxyapatite and oligomeric lactic acid in 100 mL of chloroform, sonicate for 15 minutes, then centrifuge at high speed for 15 minutes, repeat the operation 3 times to remove excess oligomeric lactic acid, and dry under reduced pressure at 40°C for 72 hours ...

Embodiment 3

[0076] Modification of embodiment 3 nanometer hydroxyapatite

[0077] 20g of oligomeric lactic acid with a number average molecular weight of 4700 was heated and dissolved in 300mL of acetone to obtain a oligomeric lactic acid acetone solution; 75g of nano-hydroxyapatite hydrosol was added to the oligomeric lactic acid-acetone solution, and the nano-hydroxyapatite The mass of water in the hydrosol is 2.5 times that of nano-hydroxyapatite. After ultrasonic treatment for 40 minutes, add 300 mL of distilled water. After filtration, dry the obtained filtrate at 80°C for 72 hours under reduced pressure to obtain nano-hydroxyapatite and oligomers. a mixture of lactic acids;

[0078] Dissolve the mixture of nano-hydroxyapatite and oligomeric lactic acid in 100 mL of chloroform, sonicate for 15 minutes, then centrifuge at high speed for 15 minutes, repeat the operation 3 times to remove excess oligomeric lactic acid, and dry under reduced pressure at 40°C for 72 hours to obtain oligom...

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Abstract

The invention provides a method for modifying nano hydroxyapatite. The method comprises the following steps of: a) providing an acetone solution with low polylactic acid, wherein the number-average molar mass of the low polylactic acid is 600 to 5,000; b) fully mixing the acetone solution with the low polylactic acid and nano hydroxyapatite sol so as to obtain a mixed solution, wherein the mass of water in the mixed solution is lower than 50 percent of the mass of acetone; and c) adding water into the mixed solution with stirring, and filtering and drying to obtain the nano hydroxyapatite with low polylactic acid surface modification. The invention also provides a nano hydroxyapatite / polylactic acid compound material and a preparation method thereof. By the method, the particle size of the modified nano hydroxyapatite with low polylactic acid surface modification is smaller and less than 2 microns; the dispersing performance of the modified nano hydroxyapatite is high; and the modified nano hydroxyapatite can still suspend in chloroform stably after being dispersed in the chloroform for 24 hours.

Description

technical field [0001] The invention belongs to the technical field of composite materials, and in particular relates to a modification method of nano-hydroxyapatite and a preparation method of nano-hydroxyapatite / polylactic acid composite material. Background technique [0002] Hydroxyapatite is the main inorganic component of human bones, with excellent biocompatibility and bioactivity; biodegradable polyesters, such as polylactic acid, polycaprolactone, polyglycolide, etc., have good biodegradability , biocompatibility and mechanical properties; the composite material obtained by blending hydroxyapatite and biodegradable polyester can combine the advantages of the two materials, and has good biocompatibility when used as bone fixation and bone repair materials , biological activity and mechanical properties. However, since hydroxyapatite is a hydrophilic inorganic material, when it is blended with polymer materials, the interfacial compatibility between the two phases is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32B82Y40/00
Inventor 赵超崔毅高战团林高强陈学思
Owner CHANGCHUN SINOBIOMATERIALS
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