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Method for preparing raw material containing Chinese date cyclic adenosine monophosphate of medicinal composition with multi-target receptor afteraction mechanism for treating melancholia

A technology of jujube cyclic adenosine monophosphate and mechanism of action, applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve problems such as decreased libido and increased suicide rate

Inactive Publication Date: 2011-08-17
戚郁芬 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the antidepressants already on the market have side effects of varying degrees, such as: increased suicide rate, headache, dizziness, dizziness, insomnia, drowsiness, tinnitus, dry mouth, anorexia, increased appetite, weight gain, blood pressure rise, gastrointestinal Discomfort, nausea, nausea, vomiting, indigestion, diarrhea, constipation, leg pain, skin rash, tremor, cramps, sweating, edema, decreased libido, impotence, etc.

Method used

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  • Method for preparing raw material containing Chinese date cyclic adenosine monophosphate of medicinal composition with multi-target receptor afteraction mechanism for treating melancholia
  • Method for preparing raw material containing Chinese date cyclic adenosine monophosphate of medicinal composition with multi-target receptor afteraction mechanism for treating melancholia
  • Method for preparing raw material containing Chinese date cyclic adenosine monophosphate of medicinal composition with multi-target receptor afteraction mechanism for treating melancholia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] see figure 1 , which is a schematic flow chart of the method for preparing the medicine of Example 1 of the present invention. exist figure 1 In the process, 20kg of ginseng was crushed first, then heated and extracted with 70% ethanol solution, separated and purified by upper column chromatography, and dried to obtain 0.8kg of ginseng extract containing 120g ginsenosides (Rg1+Rb1); then, 10kg The broken licorice was soaked at room temperature for 12 hours, extracted with water and alcohol precipitation, concentrated and dried to obtain 2 kg of licorice extract containing 200 g of glycyrrhizic acid; after that, 150 g of ginseng extract obtained by the above method and 200 g of licorice extract were pulverized and mixed uniformly Afterwards, obtain 350g (containing 22.5g ginsenoside Rg1+Rb1 and 20g glycyrrhizic acid) the pharmaceutical composition of scheme one of the present invention.

Embodiment 2

[0078] see figure 2 , which is a schematic flow chart of the method for preparing the drug of Example 2 of the present invention. exist figure 2 3.96g of glycyrrhetinic acid with a purity of 96% and 200g of the ginseng extract obtained in Example 1 were pulverized and mixed uniformly to obtain 203.96g (containing 30g ginsenosides Rg1+Rb1 and 3.8g glycyrrhetinic acid). The pharmaceutical composition of the second invention scheme.

Embodiment 3

[0080] see image 3 , which is a schematic flow chart of the method for preparing the medicine of Example 3 of the present invention. exist image 3 3.4g of prepared ginsenoside Rg1 with a purity of 90%, 7.8g of ginsenoside Rb1 with a purity of 90%, and 36.8g of 95% glycyrrhizic acid were pulverized and mixed uniformly to obtain 48g (containing 10g of ginsenoside Rg1+Rb1 and 35g glycyrrhizic acid) the pharmaceutical composition of the third scheme of the present invention.

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Abstract

The invention discloses a method for preparing a raw material containing Chinese date cyclic adenosine monophosphate of a medicinal composition with a multi-target receptor afteraction mechanism for treating melancholia, which comprises the following steps of: (a) carrying out extraction on Chinese dates to obtain first extract; and (b) purifying the first extract to obtain second extract, wherein the concentration of Chinese date cyclic adenosine monophosphate of the second extract is higher than the concentration of Chinese date cyclic adenosine monophosphate of the first extract. An experiment proves that by adopting the medicinal composition prepared according to the preparation method, the rat tail suspension immobility time can be obviously shortened and the time for body temperature dropping by induction of reserpine can be obviously reduced. An experiment result proves that compared with a mainstream medicament (Paroxetine) for treating melancholia in the prior art, the medicinal composition prepared according to the preparation method has obvious effect of resisting melancholy.

Description

[0001] This application is a divisional application of the application dated November 30, 2007, the application number is 200710194686.2, and the invention title is "Pharmaceutical composition for treating depression with multi-target receptor post-action mechanism". technical field [0002] The present invention relates to a group of raw materials containing ginsenosides Rg1, Rb1, glycyrrhizic acid and jujube cyclic adenosine monophosphate (jujube cyclic adenosine monophosphate, jujube cAMP), which are made into multi-target receptors to treat depression. The preparation method of the raw material containing jujube cyclic adenosine monophosphate of the pharmaceutical composition, especially relates to an oral medicine for treating depression with clear functional ingredients, obvious curative effect, high safety for long-term use, and avoiding side effects such as strong vomiting or The preparation method of the jujube cyclic adenosine monophosphate-containing raw material of ...

Claims

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Application Information

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IPC IPC(8): C07H19/213C07H1/08
Inventor 张作光
Owner 戚郁芬