Preparation method of drug-loaded lipid microparticles

Abstract

The invention relates to a preparation method of drug-carrying lipoid particles. In the method, a two-step freeze-drying mode is used for preparing the lipoid particles for coating and carrying water soluble drugs, wherein a primary freeze drying process is performed in a water phase system, and a secondary freeze drying process is performed in an organic phase system. The water soluble drugs are evenly coated and carried in the lipoid particles by the two-step freeze drying method, thus improving the envelopment rate of the drugs and reducing the initial burst release effect of the lipoid particles for coating and carrying the water soluble drugs. The lipoid particles prepared by the preparation method are suitable for coating various kinds of water soluble drugs and have a wide range of applicable dosage forms.

Description

【Technical field】

[0001] The invention belongs to the field of pharmaceutical preparations, and more specifically, the invention relates to a preparation method of drug-loaded lipid microparticles. 【Background technique】

[0002] Lipid particles are derived from liposomes. Liposomes, also known as niosomes, refer to single-layer or multi-layer new drug carrier single-layer vesicles made of lipid materials such as non-ionic surfactants. Higher than liposomes, it can overcome the toxicity of liposomes caused by phospholipid oxidation, and thus become a promising new drug delivery system.

[0003] Liposomes are used to encapsulate drugs, which can reduce or reduce the impact of environmental factors on drugs, prolong the effective time of drugs in vivo, improve the effective bioavailability of drugs in vivo, and reduce the toxic and side effects of drugs, especially for Targeted therapy of biologically active macromolecular drugs and heat-labile drugs.

[0004] With the rapi...