Quality control method of trollius chinensis granules
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A quality control method and the technology of nasturtium, applied in the field of traditional Chinese medicine, can solve the problems of destroying the ecological environment, unstable absorption of sample solution, etc., achieving the effects of high bioavailability, ensuring clinical efficacy, and being convenient to carry and take.
Active Publication Date: 2011-09-21
CHENGDE TIANYUAN PHARMACEUTICAL INDUSTRY CO LTD
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Problems solved by technology
[0002] At present, people realize that the extensive abuse of western medicine antibiotics has seriously damaged the human ecological environment, thus its production and use have been inhibited. On the contrary, Chinese patent medicines with antibacterial and anti-inflammatory effects have obtained unprecedented development opportunities. Therefore, making it into granules that are easy to carry, absorb faster, and take effect quickly will be welcomed by people. The development of modern pharmaceutical technology is also conducive to its large-scale production. The content determination method of total flavonoids Generally, the test solution is added with 5% sodium nitrite, 10% aluminum nitrate and sodium hydroxide for color development, and the test results show that the absorbance of the sample solution is extremely unstable after color development with this color developer. , the relative standard deviation of two hours is 26%, and the maximum absorption wavelength difference between the control substance and the test substance is nearly 10nm, and stable clinical efficacy must be guaranteed by stable production technology and quality control methods
Method used
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Embodiment 1
[0022] Take 1000g of nasturtium, add water to decoct twice, each time for 1 hour, combine the decoction, filter, the filtrate is concentrated into a thick paste with a relative density of 1.39-1.41 (50°C), add 1400g of sucrose, appropriate amount of dextrin, and mix well , granulated with ethanol, dried, and made into 2350g of glycosylated nasturtium granules.
Embodiment 2
[0024] Take 1000g of nasturtium, add water and decoct twice, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate into a clear paste with a relative density of 1.10-1.20 (50°C), add 6g of stevioside, appropriate amount of dextrin, mix Uniformly, spray-dried to make 880g of sugar-free type Trollica granules, to get final product.
[0025] The quality control method of the present invention comprises:
[0026] 【Properties】 This product is light brown to brown granules; sweet and slightly bitter.
[0027] [Identification] 1 Take 0.5g of this product (sugar-free type), grind it finely, add 10ml of ethanol, warm it in a water bath for 10 minutes to dissolve, let it cool, and filter. Take 2ml of the filtrate, add a little magnesium powder, 4-5 drops of hydrochloric acid, heat it in a water bath for 3 minutes, and it will turn red; take another 2ml of the filtrate, add 1-2 drops of 1% aluminum nitrate, it will turn yellow, and put it in a UV lamp ( 365n...
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Abstract
The invention discloses a quality control method of trollius chinensis granules, comprising property identification and content determination, wherein the property identification and content determination are carried out on flavonoids compounds. The trollius chinensis granules can be fast dissolved and dispersed in water, and has higher bioavailability. The preparation process is suitable for industrialized production, the trollius chinensis granules are convenient to carry and administrate, and suitable for administration of a patient. The quality control method has high precision, good reproducibility, low detection cost and strong operability, thus ensuring the clinically curative effect of the preparation.
Description
technical field [0001] The invention relates to a quality control method for Trollius granules, belonging to the technical field of traditional Chinese medicines. Background technique [0002] At present, people realize that the extensive abuse of western medicine antibiotics has seriously damaged the human ecological environment, thus its production and use have been inhibited. On the contrary, Chinese patent medicines with antibacterial and anti-inflammatory effects have obtained unprecedented development opportunities. Therefore, making it into granules that are easy to carry, absorb faster, and take effect quickly will be welcomed by people. The development of modern pharmaceutical technology is also conducive to its large-scale production. The content determination method of total flavonoids Generally, the test solution is added with 5% sodium nitrite, 10% aluminum nitrate and sodium hydroxide for color development, and the test results show that the absorbance of the s...
Claims
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Application Information
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