Ophthalmic gel composition
A technology of ophthalmic gel and composition, which is applied in the field of ophthalmic gel composition and its preparation, and can solve problems such as difficulty in absorption, loss, foreign body sensation in the eyes, etc.
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Embodiment 1
[0054] Preparation of Ophthalmic Gel Composition I
[0055] The components in the prescription are shown in the table below
[0056] component name
dose
% of total
role in prescription
recombinant human epidermal growth factor
(active protein)
1×10 7 IU
0.002%
Main drug
sodium hyaluronate
1.5g
0.15%
Main drug
bovine serum albumin
1.0g
0.1%
stabilizer
Alanine
3.0g
0.3%
Nutrients
[0057] Glycine
3.0g
0.3%
Nutrients
arginine
3.0g
0.3%
Nutrients
Sodium chloride
8.5g
0.85%
isotonicity regulator
Sodium dihydrogen phosphate monohydrate
1.7g
0.17%
pH regulator
Water for Injection
978.28g
97.828%
solvent
[0058] Preparation:
[0059] 1. In a 100-grade purification environment, weigh 1.5g of sodium hyaluronate and 1.0g of bovine seru...
Embodiment 2
[0064] Preparation of Ophthalmic Gel Composition II
[0065] The components in the prescription are shown in the table below
[0066] component name
dose
% of total
role in prescription
recombinant human epidermal growth factor
(active protein)
5×10 6 IU
0.001%
Main drug
sodium hyaluronate
1.0g
0.1%
Main drug
bovine serum albumin
1.0g
0.1%
stabilizer
Alanine
3.0g
0.3%
Nutrients
Glycine
3.0g
0.3%
Nutrients
Sodium chloride
8.5g
0.85%
isotonicity regulator
Disodium phosphate
2.2g
0.22%
pH regulator
Sodium dihydrogen phosphate
0.2g
0.02%
pH regulator
Water for Injection
981.09g
98.109%
solvent
[0067] Preparation:
[0068] 1. In a 100-grade purification environment, weigh 1.0g of sodium hyaluronate and 1.0g of bovine serum albumin in a 10...
Embodiment 3
[0073] Preparation of Ophthalmic Gel Composition III
[0074] The components in the prescription are shown in the table below
[0075] component name
dose
% of total
role in prescription
recombinant human epidermal growth factor
(active protein)
1×10 6 IU
0.0002%
Main drug
sodium hyaluronate
0.5g
0.05%
Main drug
bovine serum albumin
1.0g
0.1%
stabilizer
Disodium phosphate
2.2
0.22%
pH regulator
Sodium dihydrogen phosphate
0.2g
0.02%
pH regulator
Sodium chloride
8.5g
0.85%
isotonicity regulator
Water for Injection
987.58g
98.758%
solvent
[0076] Preparation:
[0077] 1. In a class 100 purification environment, weigh 0.5g of sodium hyaluronate and 1.0g of bovine serum albumin into a 1000ml volumetric flask according to the prescription, add about 300ml of water for injection an...
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