Temperature-sensitive core-shell vesicle controlled-release drug carrier, preparation method and application thereof

Abstract

The invention provides a temperature-sensitive core-shell vesicle controlled-release drug carrier which consists of liposome at the inner core and temperature-sensitive polymer composite gel at the outer layer. The stability of vesicle can be improved by core-shell configuration, and both the liposome at the inner core and the temperature-sensitive biological polymer composite gel at the outer layer can be used as drug carriers for carrying drugs. As the temperature raises, the gel at the outer layer varies so as to shrink, the drugs covered by the gel at the outer layer can be quickly released by means of temperature control, and the content of the liposome at the inner core can be slowly released owing to the presence of the gel at the outer layer, therefore, the effect of multidimensional release is achieved. The drug release carrier provided by the invention has outstanding biocompatibility and quick temperature response, can be used not only in the field of cosmetics, but also asthe carrier for an embedded drug, and is applied to implantation in open operation, injection in minimally invasive surgery and implantation by means of an endoscope.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a core-shell structured drug carrier for controlled release, more specifically to a preparation method for polymer modification on the surface of vesicles and its application as a drug carrier. Background technique [0002] Surfactants have an amphiphilic molecular structure, and are often used to enhance interfacial activity, reduce interfacial tension, or self-assemble to form micelles and liquid crystals of various shapes, which play a role in determining the rheological properties of the interface and two-phase material transfer. It plays a very important role and has important application value in cosmetics, pharmaceuticals and various emulsification and dispersion technologies. [0003] Natural biosurfactants are a class of natural compounds with surface activity. In addition to having the same effect as general chemical surfactants, they are also safe, non-toxic,...

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Problems solved by technology

However, liposomal vesicles still exist in literature D.R.Khan, E.M.Rezler, J.L.-Fields and G.B.Fields: Chem.Biol.Drug Des.71 (2008), 3 and S.Sriwongsitanont and M.Ueno: Colloid Polym.Sci .282 (2004), 753 reported problems such as easy aggregation, settlement, and poor structural stability, as well as literature S.K.E.Messerschmidt, A.Musyanovych, M.Altvater, P.Scheurich, K.Pfizenmaier, K.Landfester and R.E.Kontermann: J. Controlled Release 137(2009), 69, literature S.Sriwongsitanont and M.Ueno: Chem.Pharm.Bull.50(9)(2002), 1238 and S.Sriwongsitanont and M.Ueno: Colloid Polym.Sci.282(2004 ), the defects reported by 753 are easy to be taken up by the reticuloendothelial system, and the circulation period in the body is short. Therefore, it is necessary to further modify and process the liposome vesicle structure

At present, although some people increase the circulation time and structural stability of liposome vesicles by modifying them, they have not been prepared into a core-shell structure, and the effect is not ideal.

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