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Middle/low concentration positive quality control liquid for urine analysis

A positive quality control and urine analysis technology, applied in the field of quality control solution, can solve the problems of difficult preparation of magnesium acetoacetate, high risk of biological contamination, and limited sources of quality control substances, so as to reduce mutual interference and reduce biological risk , the effect of high sensitivity

Active Publication Date: 2011-10-26
URIT MEDICAL ELECTRONICS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the quality control materials used in the above-mentioned quality control solution are not widely sourced, expensive, and have a high risk of biological contamination. For example, human serum albumin and human red blood cells in the invention are derived from the human body; magnesium acetoacetate is difficult to prepare and expensive. more expensive

Method used

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  • Middle/low concentration positive quality control liquid for urine analysis
  • Middle/low concentration positive quality control liquid for urine analysis
  • Middle/low concentration positive quality control liquid for urine analysis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0123] Borate buffer solution with pH 5.7, 60mmol / L;

[0124] Tween-20, 40mmol / L;

[0125] Trehalose, 50mmol / L;

[0126] K30, 40mmol / L;

[0127] Glucose item: anhydrous glucose, 500mg / L;

[0128] Albumin item: bovine serum albumin, 300mg / L;

[0129] Occult blood items: bovine hemoglobin, 1mg / L;

[0130] White blood cell items: esterase, 12mg / L;

[0131] Ketone body item: acetone, 150mg / L;

[0132] Bilirubin item: 1-naphthylamine hydrochloride, 12mg / L;

[0133] Urobiliol original item: 2,5-dimethylpyrrole, 15mg / L;

[0134] Nitrite item: nitrite, 12mg / L;

[0135] Creatinine item: creatinine, 500mg / L;

[0136] Urinary calcium items: anhydrous calcium chloride, 500mg / L.

[0137] The positive quality control solution of the present invention is prepared by conventional methods. The prepared quality control solution is colorless and transparent.

[0138] In order to illustrate the effect of the quality control solution of the present invention, a comparative experiment w...

Embodiment 2

[0148] Borate buffer solution with a pH of 7.1, 135mmol / L;

[0149] Tween-20, 100mmol / L;

[0150] Trehalose, 130mmol / L;

[0151] K30, 160mmol / L;

[0152] Anhydrous glucose, 990mg / L;

[0153] Bovine serum albumin, 800mg / L;

[0154] Bovine hemoglobin, 3mg / L;

[0155] Esterase, 18mg / L;

[0156] Ethyl acetoacetate, 150mg / L;

[0157] 1-naphthylamine hydrochloride, 20mg / L;

[0158] 2,3-Dimethylindole, 40mg / L;

[0159] Nitrite, 20mg / L;

[0160] Creatinine, 1000mg / L;

[0161] Ascorbic acid, 250mg / L;

[0162] Anhydrous calcium chloride, 1500mg / L.

Embodiment 3

[0164] PH is the glycine-tris buffer solution of 6.0, 60mmol / L;

[0165] Brij35, 60mmol / L;

[0166] Lactose, 80mmol / L;

[0167] Gelatin, 80mmol / L;

[0168] Anhydrous glucose, 800mg / L;

[0169] Bovine serum albumin, 600mg / L;

[0170] Bovine hemoglobin, 2mg / L;

[0171] Esterase, 15mg / L;

[0172] Sodium ethyl acetoacetate, 150mg / L;

[0173] Direct bilirubin, 40mg / L;

[0174] Pyrrole, 40mg / L;

[0175] Nitrite, 10mg / L;

[0176] Creatinine, 1000mg / L;

[0177] Anhydrous calcium chloride, 1000mg / L.

[0178] In order to illustrate the stability effect of the quality control solution of the present invention, embodiment 3 is compared with 3 comparison groups:

[0179] Comparative group 1: Briji-35, lactose, and gelatin were not added in Example 3;

[0180] Contrast group 2: do not add lactose, gelatin in embodiment 3;

[0181] Comparative group 3: No gelatin was added in Example 3.

[0182] Each comparison group was prepared at the same time as that of Example 1, and store...

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Abstract

The invention discloses a middle / low concentration positive quality control liquid for urine analysis. The positive quality control liquid comprises a buffer solution with a pH value of 4.5 to 8.5 and a concentration of 20 to 200 mmol / L, a surfactant with the concentration of 20 to 200 mmol / L, a carbohydrate protectant with the concentration of 20 to 200 mmol / L, a protein protectant with the concentration of 20 to 200 mmol / L, anhydrous glucose with the concentration of 300 to 990 mg / L, bovine serum albumin with the concentration of 100 to 1000 mg / L, bovine hemoglobin with the concentration of0.6 to 5 mg / L, esterase with the concentration of 2 to 20 mg / L, acetone or lithium acetoacetate or sodium ethyl acetoacetate or ethyl acetoacetate with the concentration of 50 to 900 mg / L, and a direct bilirubin or naphthylamine salt with the concentration of 3 to 40 mg / L. Quality control objects of corresponding projects can be added as needed. Compared with the prior art, the quality control liquid has the advantages of good stability, high sensitivity, less toxicity of each component, wide source and low production cost.

Description

technical field [0001] The invention relates to a quality control solution for quality control of a urine chemical analysis system in urine chemical analysis testing technology, in particular to a medium-low concentration positive quality control solution for urine analysis. Background technique [0002] In the existing urine (dry chemistry) analysis test, the quality control solution is used clinically to carry out quality control on the working quality status of the urine chemical analysis system, and the test results are generally divided into N (normal, negative), ± (doubtful state), +1 (positive), +2 (positive), +3 (positive), +4 (positive), +5 (positive) and so on. The existing quality control solution is divided into negative quality control solution (contains ultra-low concentration quality control substance or does not contain corresponding quality control substance), high positive quality control solution or high concentration quality control solution (contains hig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50
Inventor 冼庆勇刘云鹏
Owner URIT MEDICAL ELECTRONICS CO LTD
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