Application of matrine to medicament for treating or preventing enterovirus 71 type infection

A technology of enterovirus and matrine, which is applied in the field of medicine, can solve the problems that the mechanism has not been detailed, and the prevention and treatment effects have not been mentioned and applied, so as to improve the quality of treatment and drug compliance, reduce the pain of treatment, Tolerance-enhancing effects
CN102240286AInactive Publication Date: 2011-11-16WUHAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
WUHAN UNIV
Publication Date
2011-11-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of matrine to a medicament for treating or preventing enterovirus 71 type infection. The invention proves that the matrine has good anti-virus effect in an in-vitro enterovirus 71 type (EV71) infection cell test. The matrine has certain killing effect on the EV71, can prevent EV71 infection, has good treatment effect on cells infected with EV71, and has good inhibition effect on virus replication, wherein the action effect is more remarkable than that of a positive control medicament ribavirin. In addition, the matrine has good inhibition effect on inflammatory reaction caused by EV71, so the medicament has a prospect of being developed into an anti-EV71 medicament.
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Description

technical field

[0001] The invention relates to the technical field of medicine, and more specifically relates to the application of matrine in a medicine for treating or preventing enterovirus 71 (EV71) infection. Background technique

[0002] Enterovirus 71 (human enterovirus 71, EV71) is a member of the Picornaviridae Enterovirus genus and was first isolated in 1969 from fecal samples of infants with central nervous system diseases in California. Usually EV71 infection will cause hand, foot and mouth disease, which is mild and mostly self-limiting, which is difficult to distinguish from hand, foot and mouth disease caused by Coxsackie A16. In addition, EV71 can also cause aseptic meningitis, brainstem encephalitis, acute flaccid paralysis, acute cardiopulmonary dysfunction and other serious neurological diseases, and even death. In recent years, EV71 has repeatedly caused disease outbreaks or epidemics in the world. For example, large-scale EV71 outbreaks occurred in the...

Claims

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