A kind of Scutellaria baicalensis extract and its preparation method and application
A Scutellaria baicalensis extract and a technology of Scutellaria baicalensis are applied in directions such as drug combinations, pharmaceutical formulations, plant raw materials, etc., and can solve the problems of inconvenience for large-scale production of medicines, high cost of extracting and separating pure baicalin, and inability to satisfy preparations, etc. , the effect of clear drug effect and simple preparation method
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Embodiment 1
[0023] Embodiment 1 Scutellaria baicalensis extract extraction method of the present invention
[0024] Take the Scutellaria baicalensis medicinal material, add water and decoct three times, 1 hour each time, combine the decoction, filter, concentrate the filtrate to an appropriate amount, add an appropriate amount of hydrochloric acid to adjust the pH value to 1.0-2.0, keep warm at 70°C, stand still, filter, and add an appropriate amount of precipitation Stir the water evenly, adjust the pH value to 7.0 with 40% sodium hydroxide solution, add an equal amount of ethanol, stir to dissolve, filter, adjust the pH value of the filtrate to 1.0-2.0 with hydrochloric acid, keep it warm at 70°C for 30 minutes, let it stand, and filter After that, the precipitate was washed with 47.5% ethanol until the pH value was 6.0-7.0, the ethanol was evaporated, and dried under reduced pressure to obtain the product.
[0025] The content of baicalin in the scutellaria baicalensis extract prepared...
Embodiment 2
[0026] Embodiment 2 The method for preparing the phospholipid complex from the Scutellaria baicalensis extract of the present invention
[0027] Weigh a certain amount of Scutellaria baicalensis extract and soybean lecithin with a PC content of 80 (weight ratio is 1:2, w / w), add absolute ethanol, the drug concentration of Scutellaria baicalensis extract is 5.0mg / ml, and keep the temperature at 55°C Stir magnetically at 120 rpm in a water bath for 2 hours, recover the solvent under reduced pressure, and dry in vacuum to obtain the phospholipid complex of Scutellaria baicalensis extract.
Embodiment 3
[0028] Embodiment 3 The impact test of different ethanol concentrations of the Radix Scutellariae extract of the present invention on the purification effect
[0029] Experimental method: take 500g of Scutellaria baicalensis, decoct and extract with water, concentrate the extract under reduced pressure at 80°C to a concentration of 0.8g / ml, add hydrochloric acid to adjust the pH to 1-2, keep it warm at 70°C for 1 hour, let stand for 12 hours, filter After that, add an appropriate amount of water to wash the precipitate, add 10 times the amount of water to the precipitate and disperse evenly, adjust the pH to 7 with 20% sodium hydroxide, divide this solution into 10 parts, and add different amounts of ethanol to 5 parts (to make the alcohol containing 10, 20, 30, 40, 47.5%) for alcohol precipitation to remove non-flavonoid impurities and inorganic impurities, then take the supernatant and adjust the pH to 1-2 with hydrochloric acid, keep it warm at 70°C for 1 hour, and let it st...
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