A dry suspension formulation containing decoquinate and its preparation method

A decoquinate and dry suspension technology, applied in the field of decoquinate dry suspension and preparation thereof, can solve the problem of stricter requirements for drug suspension effect, uneven drug distribution, and influence on the effect of chicken drinking water administration and other problems, to achieve the effect of facilitating clinical drinking water administration, improving the anticoccidial effect, and shortening the time of drinking water

Inactive Publication Date: 2011-12-14
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Second, it is dangerous
This process requires heating and melting or adding organic solvents, and also requires a drying process, which is complicated to produce and high in cost, which is not conducive to large-scale production
[0017] "Anticoccidial drug decoquinate dry suspension for livestock and poultry and its preparation method (CN101559074B; publication date: October 21, 2009)" involves a drying process, and the production process is relatively complicated
The product made by this patent is simply mixed with a surfactant, and suspended in water by the suspending effect of the surfactant. According to the Chine

Method used

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  • A dry suspension formulation containing decoquinate and its preparation method
  • A dry suspension formulation containing decoquinate and its preparation method
  • A dry suspension formulation containing decoquinate and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: prescription of decoquinate dry suspension:

[0042]

[0043] Preparation method:

[0044] After fully mixing decoquinate, urea, sodium carboxymethyl cellulose, and sodium lauryl sulfate, pulverize, pass through a 200-mesh sieve, and then fully mix with sodium cyclamate and anhydrous glucose to obtain.

Embodiment 2

[0045] Embodiment 2: Decaquinate dry suspension formulation:

[0046]

[0047] Preparation method:

[0048] After fully mixing decoquinate, urea, sodium lauryl sulfate, β-cyclodextrin, and tragacanth, pulverize, pass through a 200-mesh sieve, and then fully mix with aspartame and yuanming powder Evenly, that is.

Embodiment 3

[0049] Embodiment 3: Decaquinate dry suspension formulation:

[0050]

[0051] Preparation method:

[0052] After fully mixing decoquinate, urea, gum arabic, sodium carboxymethyl cellulose, β-cyclodextrin, and poloxamer 188, pulverize it, pass through a 200-mesh sieve, and then mix with sodium saccharin and Yuanming powder. Mix well and get it.

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Abstract

The invention relates to a dry suspension formulation containing decoquinate and a preparation method thereof, which includes a solid dispersion carrier, a wetting agent, a diluent, a sweetener, and a suspending agent, and is prepared by a special process into a uniform The decoquinate dry suspension dispersed in water for chicken drinking water administration. The invention has the advantages of simple preparation process, stable quality, good suspension effect in water, good palatability and the like. Compared with the premix, it also has the advantages of fast onset of action, high bioavailability, and convenient use.

Description

technical field [0001] The invention relates to a dry suspension formulation, in particular to a decoquinate dry suspension with anticoccidial effect that can be uniformly suspended in water and used for clinical drinking water administration and a preparation method thereof. Background technique [0002] Chicken coccidiosis is a kind of protozoan disease caused by a variety of Eimeria coccidia parasitizing in the epithelial cells of the small intestine and cecum of chickens. It is one of the main diseases that endanger the chicken industry at present. Chicken coccidiosis has the following characteristics: one is ubiquitous and occurs widely. Chicken coccidia are a parasite with a global distribution. It can almost be said that wherever chickens are raised, there is chicken coccidiosis. According to literature reports, the incidence rate of chicken coccidiosis in the world is as high as 50% to 70%, and the mortality rate when chicken coccidiosis breaks out reaches 20% to 3...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/47A61K47/40A61K47/38A61K47/34A61K47/18A61P33/02
Inventor 叶玉琴夏雪林刘爱玲王爱萍昌丽莉
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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