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Medicinal composition and soft capsule preparation for treating influenza

A composition and drug technology, applied in the direction of capsule delivery, medical preparations containing active ingredients, antiviral agents, etc., can solve the problems of capsule rupture stability, achieve stable chlorpheniramine maleate content, overcome stability Poor performance, anti-crystallization effect

Inactive Publication Date: 2013-03-27
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The soft capsule preparation can not only prevent the crystallization of ibuprofen, but also quickly take effect in vivo, and overcome the problems of capsule rupture and poor stability

Method used

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  • Medicinal composition and soft capsule preparation for treating influenza
  • Medicinal composition and soft capsule preparation for treating influenza
  • Medicinal composition and soft capsule preparation for treating influenza

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Mix 730g of PEG400 and 75g of purified water and heat to about 60°C, add 138g of ibuprofen, 110g of zinc gluconate, 2g of chlorpheniramine maleate and 12.5g of α-terpineol, then stir slowly until dissolved to obtain color transparent solution. This transparent solution was filled into capsule shells by compression method, and each capsule shell was filled with 500 mg. Wherein, the prescription of capsule shell is shown in Table 1.

[0021] Table 1 Capsule prescription

[0022] gelatin

[0023] Through carrying out the index such as the content of ibuprofen, zinc gluconate or chlorpheniramine maleate, loading difference to the compound soft capsule prepared in embodiment 1, the result is to all meet the quality inspection standard.

Embodiment 2-5

[0025] The prescription of the capsule shell and the preparation method of the soft capsule are the same as in Example 1, and the prescription of the filling solution is shown in Table 2.

[0026] The filling liquid prescription of table 2 embodiment 2-5

[0027] components

[0028] After the compound soft capsules prepared in Examples 2-5 were tested for the contents of ibuprofen, zinc gluconate or chlorpheniramine maleate, the difference in filling capacity and other indicators, the results were all in line with the quality inspection standards.

Embodiment 6

[0032] Embodiment 6 is to the stability test research of compound soft capsule preparation

[0033] At a temperature of 37-40°C and a relative humidity of 5%, the compound soft capsule preparations prepared in Examples 1-5 of the present invention and Comparative Example 1 were placed for 3 months, and the maleic acid in the filling liquid was detected once a month. Chlorpheniramine content, the results are shown in Table 3.

[0034] Table 3 Changes in the content of chlorpheniramine maleate in the compound soft capsule preparation during the accelerated process

[0035] group

0 months

1 month

2 months

3 months

Comparative Example 1

0

-0.5％

-2.6％

-7.8％

Example 1

0

+0.4％

-0.2％

-1.4％

Example 2

0

-0.5％

-0.6％

-1.6％

Example 3

0

+0.2％

-0.3％

-1.0％

Example 4

0

+0.1％

-0.2％

-0.8％

Example 5

0

...

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PUM

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Abstract

The invention relates to a medicinal composition and a soft capsule preparation for treating influenza. The medicinal composition consists of an active ingredient, alpha-terpineol, polyethylene glycol (PEG) 400 and purified water, wherein in the active ingredient, the weight ratio of ibuprofen to zinc gluconate to chlorphenamine maleate is 1:(0.5-0.8):(0.01-0.05). The soft capsule preparation canbe prepared by filling the medicinal composition into a capsule shell by a pressing method. By the compound soft capsule preparation, the problems of capsule cracking and low stability are solved while the ibuprofen is prevented from crystallizing.

Description

technical field [0001] The invention relates to a medicinal composition and a soft capsule preparation for treating colds, in particular to a medicinal composition and a soft capsule preparation for treating colds which can not only cover up the bitter taste of medicines, but also quickly act in vivo. Background technique [0002] Ibuprofen (Ibuprofen) is one of the most successful antipyretic and analgesic drugs developed in recent years. my country has listed ibuprofen as a pillar product to realize the structural renewal of antipyretic and analgesic drugs. In addition to its anti-inflammatory effect, it also has significant analgesic and antipyretic effects and good safety; its anti-inflammatory effect is 16-32 times greater than that of aspirin, its antipyretic effect is 20 times greater, and its analgesic effect is 16-32 times greater ;The antipyretic effect is faster and more durable than the main varieties of antipyretic and analgesic drugs - aspirin and paracetamol; ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/192A61K31/191A61K31/4402A61K9/48A61P31/16
Inventor 严令耕潘林梅
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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