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Preparation method of rhizoma dioscoreae nipponicae bone spur tablet

A technology of piercing keels and thorns, which is applied to medical preparations containing active ingredients, bone diseases, and pharmaceutical formulas. It can solve the problems of easy loss of heat-sensitive ingredients, low recovery rate of active ingredients, troublesome post-processing, etc., and shorten production. Cycle, good clarity, and improved extraction efficiency

Active Publication Date: 2013-08-21
太极集团重庆桐君阁药厂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above methods use percolation method and decoction method to extract the active ingredients of prescription medicinal materials, but there are cumbersome processes, long extraction time, high extraction temperature, high energy consumption, easy loss of heat-sensitive ingredients, low recovery rate of active ingredients, troublesome post-processing, etc. shortcoming

Method used

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  • Preparation method of rhizoma dioscoreae nipponicae bone spur tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Prescription: Chuanshanlong 2.7kg, Epimedium 3.24kg, Dogji 4.32kg, Sichuan Achyranthes bidentata 4.32kg, Rehmannia glutinosa 2.7kg, Lycium barbarum 1.62kg

[0036] The preparation method comprises the following steps:

[0037] a. Extraction of pangolin

[0038] a1. Crush one-third of the prescription amount of pangolin into coarse powder, set aside;

[0039] a2. Add the 60% ethanol that is equivalent to 5 times of the weight of the pangosaurus coarse powder into the batching tank; switch the three-way valve to the batching tank position, turn on the agitator, diaphragm pump and diaphragm filter press of the batching tank, and put 60% of the ethanol in the batching tank Ethanol is pumped into the membrane filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), until the filtrate returns to the batching tank, add the powder obtained in step a1 into the batching tank at a constant speed, after the addition, the membrane filter press cycle extracts ...

Embodiment 2

[0047] Prescription: Chuanshanlong 2.7kg, Epimedium 3.24kg, Dogji 4.32kg, Sichuan Achyranthes bidentata 4.32kg, Rehmannia glutinosa 2.7kg, Lycium barbarum 1.62kg

[0048] The preparation method comprises the following steps:

[0049] a. Extraction of pangolin

[0050] a1. Crush one-third of the prescription amount of pangolin into coarse powder, set aside;

[0051] a2. Add the 60% ethanol that is equivalent to 6 times of the weight of pangosaurus coarse powder in the batching tank; Switch the three-way valve to the batching tank position, open the agitator, diaphragm pump and diaphragm filter press of the batching tank, and put 60% of the alcohol in the batching tank Ethanol is pumped into the membrane filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), when the press filtrate flows back into the batching tank, add the medicine powder obtained in step a1 into the batching tank at a constant speed, after the addition is completed, the membrane filte...

Embodiment 3

[0059] Prescription: Chuanshanlong 2.7kg, Epimedium 3.24kg, Dogji 4.32kg, Sichuan Achyranthes bidentata 4.32kg, Rehmannia glutinosa 2.7kg, Lycium barbarum 1.62kg

[0060] The preparation method comprises the following steps:

[0061] a. Extraction of pangolin

[0062] a1. Crush one-third of the prescription amount of pangolin into coarse powder, set aside;

[0063] a2. Add the 60% ethanol that is equivalent to 7 times of the weight of pangosaurus coarse powder in the batching tank; Switch the three-way valve to the batching tank position, open the agitator, diaphragm pump and diaphragm filter press of the batching tank, and put 60% of the alcohol in the batching tank Ethanol is pumped into the membrane filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), when the press filtrate flows back into the batching tank, add the medicinal powder obtained in step a1 into the batching tank at a constant speed, after the addition is completed, the membrane filt...

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Abstract

The invention discloses a preparation method of a rhizoma dioscoreae nipponicae bone spur tablet. According to the preparation method disclosed by the invention, effective components in medicinal materials in a prescription are extracted by adopting a diaphragm filter press circulation, extraction and separation integrated technology instead of a percolation method or a decocting method, thus a process flow can be simplified, the production period is greatly shortened, the energy consumption is reduced, environmental protection and utilization of waste residue are facilitated, the consumptionof ethanol as an extraction solvent can be reduced, and the recovery rate of the effective components can be greatly improved.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a preparation method of a traditional Chinese medicine preparation. Background technique [0002] Chinese Pharmacopoeia 2010 Edition, Part One records: Chuanlongguci Tablet has the effects of tonifying kidney and bone, promoting blood circulation and relieving pain. It is clinically used for osteoarthritis caused by kidney deficiency and blood stasis, and the symptom is joint pain. The prescription is 270g of pangolin, 324g of epimedium, 432g of dog ridge, 432g of Sichuan achyranthes bidentata, 270g of rehmannia glutinosa, and 162g of medlar. The preparation method is to crush the pangolin, take 180g of fine powder for later use; use 70% ethanol as a solvent for the remaining pangolin powder, percolate, collect 600ml of the percolation liquid, recover the ethanol and concentrate it to a relative density of 1.20-1.25 (70°C); Add water and decoct the rest of Epimedium and other five flavors f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61P19/02A61P29/00
Inventor 冯天炯张少正殷树荣何先玉郑霞
Owner 太极集团重庆桐君阁药厂有限公司
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