Beraprost acid nanolipid microsphere preparation
A technology of beraprost acid and lipid microspheres, which is applied in the direction of medical preparations with non-active ingredients, oil/fat/wax non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of poor stability, oral preparations, biological Problems such as low availability and high storage conditions
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0040]Preheat 60g of refined soybean oil to 60-70°C, add 10g of refined soybean lecithin, stir with hand to form a uniform oil phase, then add 5mg of beraprost acid raw material drug into 1ml of ethanol to dissolve, slowly add to the above oil phase, Stir at 60-70°C at high speed (8000 rpm) for 3 minutes; add 35g of glycerin for injection, 3g of edetate disodium, 10mg of vitamin E, and 10mg of sorbitol with an appropriate amount of water for injection preheated to 60-70°C Form a uniform water phase after dilution; pour the above water phase into the mixer, slowly drop the oil phase into the water phase under the stirring condition of 10000 rpm, stir for 10 minutes, and form milky white colostrum after uniform dispersion ;Add colostrum to water for injection preheated to 60~70℃ to reach the full amount of 1000ml, transfer it to a high-pressure milk homogenizer, homogenize it under 5000~15000 Psi pressure for 10~12 times, take a sample to measure the particle size to the average ...
Embodiment 2
[0042] Preheat 70g of refined soybean oil to 60-70°C, add 12g of polyoxyethylene castor oil, stir with hand to form a uniform oil phase, then add 10mg of beraprost acid raw material drug to 1ml of ethanol to dissolve, slowly add to the above oil phase In the medium, stir at 60-70°C at high speed (8000 rpm) for 3 minutes; add 10g of glycerin for injection, 2g of edetate disodium, 15mg of vitamin E, and 10mg of sorbitol with an appropriate amount of preheated to 60-70°C Dilute with water for injection to form a uniform water phase; pour the above water phase into the mixer, slowly drop the oil phase into the water phase under the stirring condition of 10,000 rpm, stir for 10 minutes, and form a milky white after uniform dispersion Colostrum: add colostrum to the water for injection preheated to 60~70℃ to reach the full amount of 1000ml, transfer it to the high-pressure milk homogenizer, homogenize it under the pressure of 5000~15000 Psi for 10~12 times, take samples to measure th...
Embodiment 3
[0044] Mix 45g of refined soybean oil and 20g of coconut oil C8 / C10 triglyceride, preheat to 60-70°C, add 16g of poloxamer 188, stir with hand to form a uniform oil phase, then add 25mg of shellfish into 1ml of ethanol Dissolve the prostaglandin acid raw material, slowly add it to the above oil phase, stir at 60-70°C at high speed (8000 rpm) for 3 minutes; add 30g glycerin for injection, 1g sodium carbonate, 20mg vitamin E, and 15mg sorbitol Dilute an appropriate amount of water for injection preheated to 60~70°C to form a uniform water phase; pour the above water phase into the mixer, slowly drop the oil phase into the water phase under the stirring condition of 10000 rpm, Stir for 10 minutes to form milky white colostrum after uniform dispersion; add the colostrum to the water for injection preheated to 60~70℃ to reach the full amount of 1000ml, transfer it to a high-pressure homogenizer, and homogenize under the pressure of 5000~15000 Psi 10-12 times, take samples to measur...
PUM
| Property | Measurement | Unit |
|---|---|---|
| particle diameter | aaaaa | aaaaa |
| particle size | aaaaa | aaaaa |
| particle size | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More