Nano iodine-chitosan cervical disease treating membrane agent and preparation method of membrane

A technology of chitosan and therapeutic film, which is applied in the field of preparation of nano-iodine chitosan cervical therapeutic film and film, can solve the problems of affecting the curative effect, large dosage, drug and matrix outflow, etc., so as to promote wound healing and reduce discomfort Sensitive, improve the effect of bactericidal performance

Inactive Publication Date: 2012-02-01
边俊杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main external medicines in the market are divided into three categories: lotion, suppository and effervescent tablets, and there are also ointments, gels, capsules, etc. The dosage of these medicines is relatively large, and the medicine and matrix are easy to flow out from the vagina, which affects the curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Film formulation:

[0020] Povidone-iodine 20g

[0021] Dioctyldimethylammonium chloride 1g

[0022] Chlorhexidine acetate 1g

[0023] Carboxymethyl Chitosan 30g

[0024] Hydroxypropyl Methyl Cellulose 40g

[0025] Glycerin 10g

[0026] Nano carbon fiber 2g

[0027] water 400mL

[0028] Add povidone iodine, dioctyldimethylammonium chloride and chlorhexidine acetate into appropriate amount of water, stir and heat at 80°C to dissolve, add carboxymethyl chitosan, hydroxypropyl methylcellulose, glycerin, Heat and stir at 80°C for 1 hour to dissolve and mix; cool down to 50°C and stir slowly, add adsorbent, continue to stir evenly, remove air bubbles, spread the board while it is hot, and dry at 60°C for 50 minutes. Filming, cutting.

Embodiment 2

[0030] Film formulation:

[0031] Povidone-iodine 15g

[0032] Didodecyldimethylammonium chloride 2g

[0033] Chlorhexidine acetate 2g

[0034] Carboxylated Chitosan 30g

[0035] Methylcellulose 40g

[0036] Glycerin 10g

[0037] Nano carbon fiber 3g

[0038] water 400mL

[0039] Add povidone iodine, didodecyldimethylammonium chloride and chlorhexidine acetate into an appropriate amount of water, stir and heat at 80°C to dissolve, add carboxylated chitosan, methylcellulose, glycerin, and dissolve at 80°C Heat and stir at ℃ for 1 hour to dissolve and mix; cool down to 50℃ and stir slowly, add adsorbent, continue to stir evenly, remove air bubbles, spread the board while it is hot, and dry at 60℃ for 50 minutes. Filming, cutting.

Embodiment 3

[0041] Film formulation:

[0042] Povidone-iodine 10g

[0043] Didecyldimethylammonium chloride 2g

[0044] Chlorhexidine acetate 2g

[0045] Carboxylated Chitosan 25g

[0046] Sodium Carboxymethyl Cellulose 45g

[0047] Sorbitol 10g

[0048] Nano carbon fiber 3g

[0049] water 500mL

[0050] Add povidone iodine, didecyldimethyl ammonium chloride and chlorhexidine acetate into appropriate amount of water, stir and heat at 80°C to dissolve them, add carboxylated chitosan, sodium carboxymethyl cellulose and sorbitol, Heat and stir at 80°C for 1 hour to dissolve and mix; cool down to 50°C and stir slowly, add adsorbent, continue to stir evenly, remove air bubbles, spread the board while it is hot, and dry at 60°C for 50 minutes. Filming, cutting.

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PUM

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Abstract

The invention discloses a nano iodine-chitosan cervical disease treating membrane agent and a preparation method of the membrane. The treating membrane is prepared by adding plasticizer and adsorbent to chitosan, povidone iodine, dialkyl quaternary ammonium salt and chlorhexidine acetate used as main effective ingredients. The treating membrane disclosed by the invention has killing activity to multiple pathogenic microorganisms, has no irrigation to mucosa, can relieve itching, arrest bleeding and promote the growth of epidermic tissues, can be used for treating colpitis, trichomonas vaginalis, cervicitis, cervical erosion and other gynecological diseases, has better repair action on vaginal and cervical injury, and can effectively prevent the propagation of venereal diseases such as gonorrhoea, syphilis, AIDS (acquired immunodeficiency syndrome) and the like.

Description

technical field [0001] The invention relates to a medical material and a preparation method thereof, in particular to a nano-iodine chitosan cervical treatment membrane and a preparation method of the membrane. technical background [0002] Gynecological inflammation is a common and frequently-occurring disease in gynecology, among which vaginitis, cervicitis, cervical erosion, and pelvic inflammatory disease are the most common. In recent years, the incidence of women's gynecological diseases has shown a significant increase and a younger trend. According to the statistics of the World Health Organization, the incidence of various gynecological diseases among women in my country has exceeded 70%, which is worrying. [0003] Oral drugs for the treatment of gynecological diseases, such as antibacterial drugs, are not frequently used, and patients are more inclined to use external drugs for treatment. External drugs can directly act on the affected area, have fewer adverse rea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/04A61K31/79A61K9/70A61P15/00A61K31/14A61K31/155A61K31/722
Inventor 边俊杰
Owner 边俊杰
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