The invention discloses a self-repair flange gasket for pipeline connection, and belongs to the technical field of sealing elements. The self-repair flange gasket for pipeline connection can make a rapid response and trigger a self-repair action when a crack appears at the initial failure stage of the flange gasket. On the one hand, rapid development is performed to remind a technician in time byutilizing the characteristics of sensing moisture. On the other hand, the crack is actively filled based on the characteristics of gas expansion by using a prearranged repair layer, then, melting guidance is performed on a hot-melt adhesive by using a spontaneous heating material, a continuous adhesion ring is formed to cooperate with the repair layer for repair, and certain strength is achieved to resist the erosion of water to avoid the failure or separation of the adhesion ring. Effective seepage prevention is achieved for the crack, the risk of large-scale leakage caused by further failureof the flange gasket is reduced, precious time is gained for the technician to perform maintenance, and thus high losses caused by pipeline leakage are reduced.