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Baicalin-copper complexes and preparation methods thereof

A technology of baicalin copper and copper complexes, which is applied in the field of baicalin copper complexes and their preparation, can solve the problems of difficult synthesis and purification, difficulty in product purification, inability to obtain pure substances, etc., and achieves the elimination of purification steps and high product purity Effect

Inactive Publication Date: 2012-02-01
BEIJING HUAMU GREAT EXPLOIT SCI & TECH
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned two reactions all are that baicalin is dissolved in the alcohol solution, and the compound containing copper ion is reacted with baicalin under weak alkaline condition, but, under alkaline condition, can produce a large amount of Cu(OH ) 2 Precipitation, the precipitate will precipitate out together with the obtained complex, and it cannot be removed by washing with alcohol. Therefore, the complex obtained by the methods disclosed in the above two documents is actually a mixture, and the pure product cannot be obtained. And it is really difficult to separate the complex and the hydroxide precipitate, so the purification of the final product is very difficult
Existing reports on the complexes formed by baicalin and other metals also have similar difficulties and shortcomings in the synthesis and purification

Method used

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  • Baicalin-copper complexes and preparation methods thereof
  • Baicalin-copper complexes and preparation methods thereof
  • Baicalin-copper complexes and preparation methods thereof

Examples

Experimental program
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Embodiment 1

[0030] 1-1 synthetic complex

[0031] The present invention divides the experiment into two groups:

[0032] (1) Dissolve baicalin, copper sulfate or copper chloride in a non-aqueous solution, and react for 2-3 hours at different molar ratios (2:1, 1:1, 1:2) to obtain a brownish yellow precipitate. Filter, wash with ethanol several times, and dry to obtain brown-yellow flake solid A. The non-aqueous solution is one or more of methanol, ethanol, ethyl acetate and petroleum ether, and the reaction temperature is 30-80°C.

[0033] (2) Dissolve baicalin and copper acetate in non-aqueous solution respectively, and react at different molar ratios (2:1, 1:1) for 2-3 hours. The products obtained from the reaction of the two different molar ratios are brown-red precipitates, filtered, washed with ethanol several times, and dried to obtain brown-red powdered solid B. The non-aqueous solution is one or more of methanol, ethanol, ethyl acetate and petroleum ether, and the reaction temperature...

Embodiment 2

[0087] Example 2 Pharmacodynamic experiment

[0088] In vitro antibacterial test, the results of antibacterial test are shown in Table 4.

[0089] Table 4 Antibacterial test results (MIC value)

[0090]

[0091] *Because baicalin, copper chloride and copper sulfate in three ratios (2:1, 1:1, 1:2), the products obtained are the same products, and the antibacterial effect is also the same, so only one data is listed.

[0092] **Because baicalin and copper acetate at the ratio of 2:1 and 1:1 are the same products, the antibacterial effect is also the same, so only one data is listed.

[0093] Results: According to the antibacterial results, the antibacterial effects of the complexes were significantly stronger than that of baicalin. Among them, the MICs of the complexes of baicalin and copper sulfate (or copper chloride) against Staphylococcus aureus and Escherichia coli were respectively 1 / 5 and 1 / 10 of baicalin. The MIC of the complexes of baicalin and copper acetate (2:1 or 1:1) agains...

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Abstract

The invention relates to baicalin-copper complexes and preparation methods thereof, and belongs to the field of chemical pharmacy. Two baicalin-copper complexes with novel structures are prepared from different raw materials in different molar ratios; after the complexes are subjected to in-vitro bacteriostatic experiments, results indicate that the complexes have a high bacteriostatic function; and compared with baicalin-metal complexes disclosed in the prior art, the baicalin-copper complexes have better medicinal effect and can serve as feed additives. The invention also provides preparation methods for the baicalin-copper complexes. The methods are simple, and easy to control; and the final products have high purity.

Description

Technical field [0001] The present invention relates to the field of chemical medicine, in particular to a baicalin copper complex and a preparation method thereof. Background technique [0002] Baicalin is an important natural medicine and active ingredient of Chinese medicine. Its biological activity is extremely wide. It has antibacterial, hypoglycemic, antiviral, anti-inflammatory, diuretic, anti-tumor, anti-oxidant free radical, anti-allergic and antispasmodic, etc. Kind of pharmacological effects. [0003] Fe and Cu are the first and second essential trace elements in the human body. There are a variety of important enzymes containing Cu in the body. Cu activates the formation of hemoglobin and promotes the absorption and utilization of iron. It is useful in electron transfer, elastin synthesis, connective tissue metabolism, purine metabolism, phospholipid and nerve tissue formation. important meaning. [0004] Many studies have shown that baicalin can increase its biologica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F1/08A61P31/04A23K1/16
CPCA23K1/1612A23K1/1618C07F1/08A23K20/111A23K20/121A61P31/04
Inventor 石建华李逐波罗绪刚刘全盛云鹤
Owner BEIJING HUAMU GREAT EXPLOIT SCI & TECH
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