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Chloramphenicol molecular imprinting polymer microballoon with uniformity in size as well as preparation method and application thereof

A technology of molecular imprinting and chloramphenicol, applied in alkali metal compounds, chemical instruments and methods, alkali metal oxides/hydroxides, etc., can solve problems such as low adsorption efficiency, poor particle size uniformity, and tailing

Inactive Publication Date: 2012-02-01
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there have been literature reports on molecularly imprinted polymers of chloramphenicol, which are mainly prepared by two methods: first, solution polymerization or bulk polymerization is used, and the molecularly imprinted polymers of chloramphenicol are blocky and have low resolution , and the adsorption efficiency is low, and when used as a chromatographic packing, it is easy to cause broadening of the chromatographic peak and severe tailing; secondly, the suspension polymerization method is used to prepare molecularly imprinted polymer microspheres with better spherical shape, but the obtained chloramphenicol The particle size uniformity of molecular polymer microspheres is poor, usually the coefficient of variation CV>35%, which affects the selective adsorption effect, and when used in chromatographic media, it needs to be sieved to obtain microspheres with a certain particle size range, resulting in waste

Method used

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  • Chloramphenicol molecular imprinting polymer microballoon with uniformity in size as well as preparation method and application thereof
  • Chloramphenicol molecular imprinting polymer microballoon with uniformity in size as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]First prepare the dispersed phase solution, ultrasonically dissolve 1 mmol of template molecule chloramphenicol in 6 mL of porogen chloroform and ethyl acetate (1:1 by weight), add 4 mmol of functional monomer 4-vinylpyridine, crosslinking agent EDMA 20mmol, initiator azobisisobutyronitrile AIBN 0.18g, the solution was ultrasonically degassed for 5min, nitrogen gas deoxygenated for 15min, then the solution was moved into the syringe of the syringe pump (avoid air entering the syringe as much as possible); the continuous phase solution was Add 0.9 g of dispersant PVA into 60 mL of water, stir to dissolve, ultrasonically degas for 5 min, pass nitrogen gas for deoxygenation for 20 min, and place in a continuous phase container.

[0040] The continuous phase was stirred at 180 rpm and sparged with nitrogen. Driven by the syringe pump, the dispersed phase solution enters the square chamber of the microfluidic device through the connecting tube, and then enters the continuous ...

Embodiment 2

[0044] First prepare the dispersed phase solution, ultrasonically dissolve 1 mmol of the template molecule chloramphenicol in 6 mL of the porogen ethyl acetate, add 3 mmol of the functional monomer 4-vinylpyridine, 30 mmol of the cross-linking agent EDMA, and the initiator azobisisobutyronitrile AIBN 0.15g, the solution was ultrasonically degassed for 5min, nitrogen gas deoxygenated for 15min, and then the solution was moved into the syringe of the syringe pump (try to avoid air entering the syringe); to prepare a continuous phase solution, add dispersant PVA 0.6g to 60mL water, Stir to dissolve, ultrasonically degas for 5 minutes, pass through nitrogen to remove oxygen for 20 minutes, and place in a continuous phase container.

[0045] The continuous phase was stirred at 200 rpm and sparged with nitrogen. Driven by the syringe pump, the dispersed phase solution enters the square chamber of the microfluidic device through the connecting tube, and then enters the continuous pha...

Embodiment 3

[0048] First prepare the dispersed phase solution, ultrasonically dissolve 1 mmol of template molecule chloramphenicol in 5 mL of porogen ethyl acetate, add functional monomer methacrylic acid 2 mmol, crosslinking agent EDMA 20 mmol, initiator azobisisobutyronitrile AIBN 0.20 g, the solution was ultrasonically degassed for 5 minutes, and deoxygenated with nitrogen for 15 minutes, and then moved the solution into the syringe of the syringe pump (try to avoid air entering the syringe); to prepare a continuous phase solution, add 0.6 g of dispersant PVA to 60 mL of water, and stir to dissolve , ultrasonically degassed for 5 minutes, passed through nitrogen to remove oxygen for 20 minutes, and placed in a continuous phase container.

[0049] The continuous phase was stirred at 150 rpm and sparged with nitrogen. Driven by the syringe pump, the dispersed phase solution enters the square chamber of the microfluidic device through the connecting tube, and then enters the continuous ph...

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Abstract

The invention discloses a chloramphenicol molecular imprinting polymer microballoon which has mean grain size of 1mum to 300mum and grain size distribution coefficient C.V of not more than 15 percent. The preparation method of the chloramphenicol molecular imprinting polymer microballoon comprises the following steps of: firstly, preparing emulsion by using a micro-fluidic device; secondly, curing the emulsion to obtain a molecular imprinting microballoon, wherein the micro-fluidic device comprises a plurality of micro channels; generating the emulsion when a dispersion phase is driven by an injection pump to enter a continuous phase from the micro channels; transferring the emulsion to another container and curing to obtain a polymer microballon; eluting the polymer microballon to remove a template molecule; and obtaining the molecular imprinting polymer microballoon. The dispersion phase contains the template molecule of chloramphenicol, a functional monomer, a cross linker, an evocating agent and a pore-foaming agent; and the continuous phase contains water and a dispersion agent. The invention also provides application of the chloramphenicol molecular imprinting microballoon.

Description

technical field [0001] The invention relates to the fields of functional polymer materials, biochemical separation and analytical chemistry. More specifically, it relates to a molecularly imprinted polymer microsphere of chloramphenicol with uniform size. [0002] The present invention also relates to a preparation method of the molecularly imprinted polymer microsphere. [0003] The present invention also relates to the application of the molecularly imprinted polymer microspheres. Background technique [0004] With the increase of people's demand for animal food, the problem of veterinary drug residues in animal food has increasingly become the focus of common concern of the whole society. In order to protect the health of our people and effectively control the residues of veterinary drugs in edible animal products, it is necessary to vigorously carry out the detection of trace veterinary drug residues in animal-derived products. [0005] Chloramphenicol (Chloramphenico...

Claims

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Application Information

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IPC IPC(8): C08F222/14C08F226/06C08F220/06C08F212/36C08F220/56C08F220/28C08F2/22C08J9/26B01J20/285B01J20/30B01J20/28
Inventor 雷建都马光辉苏志国寇星翟艳琴
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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