External preparation containing analgesic/Anti-inflammatory agent

A topical, anti-inflammatory technology, applied in the directions of anti-inflammatory agents, medical preparations containing active ingredients, and medical preparations with non-active ingredients, etc., can solve the problems of lack of records and hints for improving efficacy performance, and achieve aesthetics. Excellent, low concentration, the effect of improving the efficacy of the drug

Inactive Publication Date: 2012-02-01
KOWA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there is no report in any of the documents about the improvement of the efficacy of amfenac or its salts caused by the combined use of polyhydric alcohols and polyoxyalkylene alkyl ethers and / or polyoxyalkylene alkenyl ethers. Specific records and hints

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Embodiment 1 patch

[0099] 30.0 g of styrene-isoprene-styrene block copolymer (SIS5505P, JSR Co., Ltd.), 24.0 g of terpene resin (YS resin PX1150N, Yasuhara Chemical Co., Ltd.) were dissolved in 100.0 g of ethyl acetate. ), 20.0 g of polybutene (polybutene 3SH, NOF Corporation) and 17.0 g of light liquid paraffin (HICALL M72, Kaneda Corporation) to obtain a binder phase.

[0100] Add 1.0 g of amfenac sodium to 2.0 g of polyoxyethylene (2) lauryl ether (NIKKOL BL-2, Nihon Surfactant Kogyo K.K), and after confirming the dissolution, add 0.15 g of diisopropanolamine (diisopropyl Alcoholamine, Mitsui Fine Chemical Inc.), 0.5 g of dibutyl hydroxytoluene (Yoshinox BHT, API Corporation), 3.0 g of propylene glycol (Propylene Glycol, ADEKA), 2.0 g of oleyl alcohol (NOVOL J, Corda Japan K.K) and 1.0g of l-menthol (l-menthol (menthol), Suzuki Mentha (Co., Ltd.)), was added to the previously prepared binder phase, fully mixed to obtain a medicinal solution.

[0101] Spread the d...

Embodiment 2

[0102] Embodiment 2 patch

[0103] Except having changed light liquid paraffin into 15.0 g, and propylene glycol into 4.0 g, it carried out similarly to Example 1, and obtained the patch which mix|blended 1 mass % of amfenac sodium.

Embodiment 3

[0104] Embodiment 3 patches

[0105] A patch containing 1% by mass of amfenac sodium was obtained in the same manner as in Example 1, except that propylene glycol was changed to polyethylene glycol 400 (polyethylene glycol 400, NOF Corporation).

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PUM

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Abstract

Disclosed is an external preparation which contains the following components (A), (B) and (C). (A) a nonsteroidal analgesic / anti-inflammatory agent (B) a polyhydric alcohol (C) a polyoxyalkylene alkyl ether and / or a polyoxyalkylene alkenyl ether The nonsteroidal analgesic / anti-inflammatory agent contained in the external preparation has improved medicinal effects, and thus the external preparation can be effective at a low concentration. In addition, the external preparation has excellent appearance.

Description

technical field [0001] The present invention relates to external preparations containing nonsteroidal analgesic-anti-inflammatory agents. Background technique [0002] Amfenac or its salt, a non-steroidal anti-inflammatory analgesic of phenylacetic acid, is used for chronic rheumatoid arthritis, osteoarthritis, low back pain, frozen shoulder, neck, shoulder and wrist syndrome, temporomandibular joint disease and after surgery , After trauma, after tooth extraction, etc., anti-inflammatory-analgesic as a function-effect, a capsule containing 50 mg of amfenac sodium in 1 capsule was used. However, amfenac or a salt thereof must be administered orally four times a day because of its short blood half-life. In addition, since amfenac or a salt thereof inhibits the biosynthesis of prostaglandins, it may cause damage to the gastrointestinal mucosa as a side effect (Non-Patent Document 1). [0003] In order to solve such a problem, amfenac or a salt thereof has been demanded as an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K9/06A61K9/08A61K9/12A61K9/70A61K31/196A61K47/08A61K47/10A61K47/34A61K47/44A61P29/00
CPCA61K9/7053A61K31/196A61K31/05A61K45/06A61P25/04A61P29/00A61K2300/00A61K9/06A61K47/08A61K47/34
Inventor 三浦诚司粟村努山崎裕洋藤井裕也
Owner KOWA CO LTD
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