Method for preparing core-shell structured intelligent nano hydrogel

A nano-hydrogel, core-shell structure technology, applied in the field of preparation of smart hydrogel, can solve the problems of difficult removal, harmful to human body, limited application scope of smart hydrogel, etc., and achieves good stability, controllable size, Good effect of dual responsiveness to pH and temperature

Inactive Publication Date: 2012-02-22
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Researchers have synthesized single-responsive hydrogels or multiple-responsive hydrogels with a core-shell structure, using methods such as precipitation polymerization and emulsion polymerization. The core layer or core layer of the core-shell structure hydrogel synthesized by these methods The shell layer is a random copolymer, and organic solvents and emulsifiers remain in the polymerization system. These substances are not easy to completely remove and are harmful to the human body, which limits the application range of smart hydrogels.

Method used

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  • Method for preparing core-shell structured intelligent nano hydrogel
  • Method for preparing core-shell structured intelligent nano hydrogel
  • Method for preparing core-shell structured intelligent nano hydrogel

Examples

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Embodiment 1

[0031] (1) 2g hydroxypropyl cellulose (HPC, Mw=1.0×10 5 ) powder was dissolved in 198g deionized water, stirred by magnetic force for 4 days, and prepared into a solution with a mass fraction of HPC of 1%;

[0032] (2) Dissolve 20g of a solution with a mass fraction of HPC of 1% and 0.30g of methacrylic acid in 74.5g of deionized water, and stir magnetically in water at 24°C for 15 minutes; add 0.10g of BIS, stir magnetically for 15 minutes, and then pass nitrogen gas for 60 minutes ; 0.10g APS was dissolved in 5.0g deionized water, then added to the above-mentioned reaction solution, and nitrogen was continued for 45 minutes; 0.05g TMEDA was added to observe the reaction, and the polymethacrylic acid nano-hydrogel obtained was then dialyzed for 4 days, Then adjust the pH to 3.0 with hydrochloric acid, magnetically stir in water at 24°C, and blow nitrogen gas for 60 minutes to obtain solution A;

[0033] (3) Dissolve 0.50 g of N-isopropylacrylamide and 0.30 g of BIS in 40.0 g...

Embodiment 2

[0036] (1) 2g hydroxypropyl cellulose (HPC, Mw=1.0×10 5 ) powder was dissolved in 198g deionized water, stirred by magnetic force for 4 days, and prepared into a solution with a mass fraction of HPC of 1%;

[0037] (2) Dissolve 40g of a solution with a mass fraction of HPC of 1% and 0.30g of methacrylic acid in 90.55g of deionized water, and stir magnetically in water at 24°C for 30 minutes; add 0.10g of BIS, stir magnetically for 30 minutes, and then pass nitrogen gas for 50 minutes ; 0.05g APS was dissolved in 9.0g deionized water, then added to the above-mentioned reaction solution, and nitrogen was continued for 45 minutes; 0.06g TMEDA was added to observe the reaction, and the prepared polymethacrylic acid nano-hydrogel was dialyzed for 6 days. Then adjust the pH to 3.5 with hydrochloric acid, magnetically stir in water at 24°C, and pass nitrogen gas for 60 minutes to obtain solution A;

[0038] (3) Dissolve 1.50g of N-isopropylacrylamide and 0.10g of BIS in 40.0g of dei...

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Abstract

The invention relates to a method for preparing a core-shell structured intelligent nano hydrogel. The method comprises the following steps of: (1) preparing an aqueous solution of hydroxy-propyl cellulose (HPC); (2) dissolving the aqueous solution of HPC and acrylic monomers in deionized water, stirring, adding a crosslinking agent and an initiator, introducing nitrogen, adding an accelerator, stirring to obtain a polyacrylic nano hydrogel, dialyzing for 3 to 7 days, and regulating the pH value to be 3-4 to obtain a solution A; (3) dissolving acrylamide monomers and a crosslinking agent in deionized water, stirring, and introducing nitrogen to obtain a solution B; and (4) pouring the solution B into the solution A obtained in the step (2), introducing nitrogen to obtain a solution C, adding an initiator, heating, introducing nitrogen, and adding an accelerator finally. The preparation method has the advantages of mild reaction conditions and simple and easily controlled equipment; and the prepared nano hydrogel has controlled size, high stability, pH and temperature dual responsibility and high biosafety, and can be applied to the field of control release of medicines.

Description

technical field [0001] The invention belongs to the field of preparation of intelligent hydrogels, in particular to a preparation method of intelligent nano hydrogels with core-shell structure. Background technique [0002] Gels that can sense small changes in the external environment (such as temperature, pH, light, electricity, magnetism, pressure, etc.) and undergo reversible volume phase transitions or sol-gel phase transitions are called smart hydrogels. Due to its extremely small size and huge surface area, smart nanohydrogels can exhibit extremely fast shrinkage and swelling to external environment stimuli. Targeted drugs, tissue engineering, immobilization of active enzymes, chemical converters, memory element switches, sensors, artificial muscles, and light-adjusting materials have good application prospects. [0003] Due to the complexity of the environment and the needs of social development, nano-hydrogels with a core-shell structure have become a hot spot for r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L33/24C08L33/02C08L1/26C08F220/54C08F220/06C08F2/22C08J3/24
Inventor 邱高邵巧兰鲁希华
Owner DONGHUA UNIV
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