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Gene chip for forecasting curative effect of maze surgery on atrial fibrillation

A gene chip and surgical treatment technology, which is applied in the field of gene chips for predicting the efficacy of maze surgery for atrial fibrillation, and achieves the effects of high sensitivity and large throughput

Inactive Publication Date: 2012-02-29
HANGZHOU BOTAI GENE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no specific and sensitive predictors and models for the recurrence of atrial fibrillation for the Asian population, and there is no application of multi-gene and multiple related SNP locus prediction chips for the recurrence of atrial fibrillation at home and abroad.

Method used

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  • Gene chip for forecasting curative effect of maze surgery on atrial fibrillation
  • Gene chip for forecasting curative effect of maze surgery on atrial fibrillation
  • Gene chip for forecasting curative effect of maze surgery on atrial fibrillation

Examples

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Embodiment Construction

[0059] The present invention will be described in further detail below in conjunction with specific embodiment, but content of the present invention is not limited to following embodiment, those skilled in the art can propose other embodiment within the framework of the technical scheme of the present invention, but these embodiments All are included in the scope of protection of the present invention.

[0060] The scale-up of the implementation of the following examples without specifying the specific conditions is usually carried out according to the conventional conditions, or according to the conditions suggested by the manufacturer.

[0061] The gene chip for predicting the curative effect of maze operation on atrial fibrillation of the present invention includes oligos designed for rs2200733 loci, rs10033464 loci, rs13376333 loci, rs6843082 loci, rs17042171 loci, rs2106261 loci and rs7193343 loci Nucleotide probes and specific primers capable of specifically amplifying D...

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Abstract

The invention discloses a gene chip for forecasting a curative effect of a maze surgery on atrial fibrillation. The gene chip comprises an oligonucleotide probe designed according to an rs2200733 site, an rs10033464 site, an rs13376333 site, an rs6843082 site, an rs17042171 site, an rs2106261 site and an rs7193343 site and a specific primer capable of specifically amplifying DNA segments comprising the single nucleotide polymorphism (SNP) sites, wherein the 5' end of the specific primer is marked by a signal substance in advance. The gene chip can detect a plurality of SNP sites obviously related to atrial fibrillation, can screen the common people quickly and conveniently, is high in accuracy and low in cost, can be applied to batch detection, and can completely meet the large-scale gene screening requirement.

Description

technical field [0001] The invention relates to a gene chip, in particular to a gene chip for predicting curative effect of maze operation on atrial fibrillation. Background technique [0002] Atrial fibrillation (atrial fibrillation) referred to as "atrial fibrillation", it is a common arrhythmia, often complicated by rheumatic heart disease, coronary heart disease and congenital heart disease. Atrial fibrillation can trigger heart failure or hemodynamic disorders, induce fatal arrhythmias such as ventricular tachycardia or ventricular fibrillation, lead to thrombosis and embolism events, increase the mortality rate of underlying heart disease, and increase the risk of stroke by five times. The risk of heart failure is quadrupled, the risk of death or dementia is tripled, and atrial fibrillation itself can cause an enlarged heart. [0003] According to the definition of the World Health Organization, the symptoms of atrial fibrillation are the loss of normal and regular sy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C40B40/06C40B50/06
Inventor 金涛王海勇郭兴中陈艳丽符伟红孙早
Owner HANGZHOU BOTAI GENE TECH
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