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Preparation method for maleoyl chitosan polymer microspheres

A technology of maleylated chitosan and polymer, which is applied in the field of preparation of maleylated chitosan polymer microspheres, can solve the problems of constraints, tedious steps of hollow microspheres, small particle size of microspheres, etc. Achieve the effect of easy operation, retained activity and good biocompatibility

Active Publication Date: 2012-10-03
HEBEI NORMAL UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The steps to prepare hollow microspheres are cumbersome, and the particle size of the microspheres is small, which limits the application

Method used

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  • Preparation method for maleoyl chitosan polymer microspheres
  • Preparation method for maleoyl chitosan polymer microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add 30ml of ethyl acetate, 1mL of Span-80, and 7ml of methyl acrylate into a 100mL four-neck flask, rotate at 800R / min, and adjust the temperature to 65°C. After 0.5h, add 6ml, the mass fraction is 1% maleylated chitosan aqueous solution, 1mL 5% ammonium persulfate initiator, and heat up to 75°C and stir evenly, then add 3mL 4% water-soluble cross-linking agent N, N-methylenebisacrylamide, react for 1h. After the product was cooled to room temperature, it was washed three times with ethyl acetate to remove unreacted reactants and by-products, and then washed three times with absolute ethanol or acetone by gradient elution method to obtain a smooth surface and a honeycomb inside. Polymer microspheres with a similar structure are shown in microscope reference pictures 1 and 2.

[0025] The particle size of the microspheres obtained in the present invention can be between 100-300 μm, or according to application requirements, the particle size of the microspheres can be sm...

Embodiment 2

[0027] Add 30ml of ethyl acetate, 1mL of Span-80, and 7ml of n-butyl methacrylate into a 100mL four-neck flask, rotate at 800R / min, and adjust the temperature to 65°C. After 0.5h, add 6ml, the mass fraction is 2% maleylated chitosan aqueous solution, 1mL 5% ammonium persulfate initiator, and heat up to 75°C and stir evenly, then add 3mL 4% water-soluble cross-linking agent N, N-methylenebisacrylamide, react for 3h. After the product was cooled to room temperature, it was washed three times with ethyl acetate to remove unreacted reactants and by-products, and then washed three times with absolute ethanol or acetone by gradient elution method to obtain a smooth surface and a honeycomb inside. polymer microspheres.

Embodiment 3

[0029] Add 30ml of ethyl acetate, 1mL of Span-80, and 7ml of methyl methacrylate into a 100mL four-neck flask, rotate at 800R / min, and adjust the temperature to 65°C. After 0.5h, add 6ml, the mass fraction is 2% maleylated chitosan aqueous solution, 1mL 5% ammonium persulfate initiator, and heat up to 75°C and stir evenly, then add 3mL 4% water-soluble cross-linking agent N, N-methylenebisacrylamide, reaction 6h. After the product was cooled to room temperature, it was washed three times with ethyl acetate to remove unreacted reactants and by-products, and then washed three times with absolute ethanol or acetone by gradient elution method to obtain a smooth surface and a honeycomb inside. polymer microspheres.

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Abstract

The invention discloses a preparation method for maleoyl chitosan polymer microspheres. The preparation method comprises the following steps of: adding an oil phase solvent, a small amount of emulsifier and monomer into a flask; adjusting rotation speed; heating to 65 DEG C; adding maleoyl chitosan aqueous solution and ammonium persulfate initiator after 0.5 hour; heating to 75 DEG C and uniformly stirring; then adding aqueous crosslinking agent N,N-methylene-bisacrylamide and reacting for 1-6 hours; cooling a product to room temperature; washing for 3 times by using the oil phase solvent; removing unreacted reactant and byproduct; AND washing for 3 times with absolute ethyl alcohol or acetone by using a gradient elution method to obtain the AMCS (Magnetic Activated Cell Sorting) microspheres. The microspheres are high molecular microspheres with smooth outer surfaces and internal honeycomb structures; a template is not required to be removed; the method is easy and convenient to operate; and the activity of an embedding substance can be maintained to the greatest extent. The microspheres can be used as a medicament control and release catalyst carrier, and have broad application prospect and practical value.

Description

technical field [0001] The invention relates to a polymer material and a preparation method thereof, in particular to a preparation method of maleylated chitosan polymer microspheres with a smooth appearance and a honeycomb structure inside. Background technique [0002] Hollow microsphere is a kind of polymer material with a special structure, the particle size is micron or nanoscale, it has broad application prospects in drug control and release cell immobilization and catalyst carrier, etc. In recent years, polymer In the field of research, it has received extensive attention. So far, the methods for preparing polymer hollow microspheres mainly include: industrial synthesis method, template method, self-assembly method, interfacial polymerization reaction and emulsion polymerization method. Spray drying method is one of the most widely used methods for preparing hollow microspheres in industry. This method Based on hot air drying of atomized droplets, spray drying method...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F251/00C08F2/24C08J9/00
Inventor 杨越冬侯文龙杨婷
Owner HEBEI NORMAL UNIVERSITY OF SCIENCE AND TECHNOLOGY