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Submicron powder cough powder normal temperature preparation method

A technology of ultra-fine powder and normal temperature, which is applied in the direction of powder transportation, pharmaceutical formulations, and medical preparations containing active ingredients, etc. It can solve the problems of restricting the large-scale production of veterinary Chinese medicine ultra-fine powder, low bioavailability, and reduced crushing efficiency. Achieve the effect of being suitable for large-scale industrial production, increasing cell wall breaking rate, improving smell and taste

Active Publication Date: 2013-09-25
HENAN KANGXING PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The cough powder currently used for poultry is a coarsely crushed powder, which has the disadvantages of large dosage, coarse dosage form, and poor appearance. The feed is evenly mixed and cannot be directly added to drinking water
[0004] Traditional Chinese medicine ultrafine pulverization technology is an update and development of traditional pulverization technology. It not only retains the advantages of traditional Chinese medicine preparation technology, but also injects new vitality into the modern production of Chinese medicine. It has broad application prospects, but there are still some problems in actual production. Problems and problems: (1) Low production efficiency and high energy consumption are the main factors restricting the large-scale production of veterinary traditional Chinese medicine ultrafine powder
In the traditional closed-circuit crushing process of the rod mill, when most of the materials have reached the fineness requirement, there is always a small part of coarse powder mixed in it, and the crushing time needs to be greatly extended to further crush this part of the coarse powder to the required particle size , so that the crushing efficiency is reduced, and the energy consumption is greatly increased; (2) There is a difference in particle size uniformity of the material after classification in winnowing classification and classifying wheel classification, which greatly affects the production quality of Chinese veterinary drug compound superfine powder, especially in the application of animal When using drinking water, it is difficult to meet the usage requirements due to the existence of a small amount of unbroken cells
(3) In the traditional unidirectional airflow screening, when Chinese medicine is ultrafinely pulverized, as the particle size decreases, the surface area and surface energy of the material particles increase, the adsorption increases, the fluidity becomes poor, and it is easy to aggregate into large particles It is difficult to sieve and classify powders with a fineness of more than 200 mesh

Method used

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Embodiment Construction

[0039] Such as figure 1 , 2 Shown, the normal temperature preparation method of superfine powder Zhike powder of the present invention, comprises the following steps:

[0040] The first step, according to the weight ratio of 5:4:3:6:5:5:5:5:5:6:5:5:4:3, weigh Anemarrhena anemarrhena, Citrus aurantium, Ephedra, bellflower, bitter almond, Tinglizi, mulberry bark, tangerine peel, gypsum, Peucedanum, shegan, loquat leaves, licorice, washed and dried, cut into 3-5cm long sections, dried naturally or until the moisture content is ≤10% ;

[0041] In the second step, the above-mentioned traditional Chinese medicines are respectively pulverized at a temperature of 20 ° C to 25 ° C to obtain coarse powder of traditional Chinese medicines with a particle size of 60 to 80 meshes; the oils in bitter almonds and Tinglizi are extracted with No. 6 solvent oil Extract spare;

[0042] The 3rd step, the coarse powder of above-mentioned crude drug is mixed evenly, then add bitter almond, Tin...

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Abstract

The invention discloses a submicron powder cough powder normal temperature preparation method, which comprises the following steps that: rhizoma anemarrhenae, bitter orange, herba ephedra, balloon flower, bitter almond, lepidium seeds, cortex mori radicis, dried orange peel, gypsum, peucedanum root, blackberry lily, folium eriobotryae and liquorice are weighed according to proportion, dried and pulverized, and oil in the bitter almond and the lepidium seeds is extracted; the coarse powder and the dregs of the bitter almond and the lepdium seeds are mixed and are placed inside a rod mill to be pulverized, then the mixed powder is blown into a special two-way airflow screen grader to be screened to obtain the powder with the granularity being less than or equal to 25nm, and the powder is conveyed by the airflow produced by a draught fan into a cyclone collector to be collected and to obtain the cough submicron powder; the powder cannot pass through a 500-mesh sieve is collected by a funnel and is conveyed into the rod mill through a pipeline to be circularly pulverized; and the cough submicron powder finished product is obtained by adequately mixing the cough submicron powder and the bitter almond oil and the lepdium seed oil. The preparation method has the advantages that: the entire preparation process is carried out under the normal temperature, and the granularity of the finished product medicine is less than or equal to 25nm; and the two-way airflow screen grader which is utilized in the method can simplify the preparation process of the submicron powder cough powder.

Description

technical field [0001] The invention relates to the field of veterinary drug preparations, in particular to a normal-temperature preparation method of superfine powder Zhike powder; the invention also relates to a special two-way airflow sieving machine used in the method. Background technique [0002] Chinese herbal medicine has incomparable advantages over other chemically synthesized drugs in the prevention and treatment of diseases: high safety, less toxic and side effects, more active ingredients, less harmful residues, more targets of action, can play a combined effect, and is not easy to produce drug resistance It can regulate the body's immunity and enhance the body's disease resistance while antibacterial and antiviral. Under the background that countries around the world are increasingly emphasizing food safety and calling for green and ecological conditions, it is of great practical significance to promote the application of traditional Chinese veterinary drugs fo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8964A61K9/14B02C23/20A61P11/14A61K33/06
Inventor 马仲彬郭振环李中亚冯永健温士杰
Owner HENAN KANGXING PHARMA
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