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N,N'-dipyrene butyryl lysine and application thereof

A dipyrene butyryl lysine, solution technology, applied in the field of the new compound nitrogen, nitrogen'-dipyrene butyryl lysine, can solve the detection interference of lead ions, fluorescence quenching, and the development of lead ion fluorescent probes Obstacles and other problems, to achieve the effect of being conducive to reuse

Inactive Publication Date: 2012-05-02
SOUTH CHINA NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, due to the strong charge, electron or energy transfer ability of heavy metal ions, they often show fluorescence quenching performance. In actual detection, they are easy to interfere with the detection of lead ions. development of the

Method used

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  • N,N'-dipyrene butyryl lysine and application thereof
  • N,N'-dipyrene butyryl lysine and application thereof
  • N,N'-dipyrene butyryl lysine and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Synthesis of Nitrogen, Nitrogen'-Dipyrenebutyryllysine

[0036]

[0037] The synthetic route of nitrogen, nitrogen '-dipyrene butyryl lysine is shown in formula (II), and concrete synthetic steps are as follows:

[0038] (1) Synthesis of Lysine Methyl Ester Hydrochloride

[0039]Add 5.0 mL of anhydrous methanol to a round bottom flask, cool in an ice-salt bath for 5 min, and slowly add 1.0 mL of thionyl chloride dropwise to it. After the dropwise addition, 1.0 g (6.85 mmol) of lysine solid was added to the above dichloromethane solution at one time. The mixed system was first stirred in an ice-salt bath for 10.0 min, and then stirred at room temperature for 2 h. Thereafter, the mixed solution was refluxed for 30 min under heating in a water bath at 70-80° C. and then cooled to room temperature. After most of the methanol in the solution was evaporated to dryness, 40.0 mL of anhydrous ether was added to the system, and a solid substance was precipitated. The mixed...

Embodiment 2

[0049] Detection method of lead ion concentration

[0050] Titrate the concentrated solution of lead ions to a concentration of 2.0×10 -5 mol / L nitrogen, nitrogen'-dipyrenebutyryl lysine aqueous solution makes the concentration of lead ion respectively 0.0, 0.1, 0.25, 0.5, 1.0, 2.0, 3.0, 4.0, 8.0, 12.0, 16.0, 20.0, 40.0 μM (×10 -6 mol / L), and respectively detect their fluorescence intensity at the excitation wavelength of 350nm, and draw the fluorescence spectrum diagram, the fluorescence spectrum diagram obtained is as follows figure 1 shown.

[0051] With the addition of lead ions, the fluorescence emission peak of nitrogen, nitrogen '-dipyrenebutyryl lysine weakens gradually and white flocculent precipitates (such as figure 2 shown). When the concentration ratio of the two is 1:1, the fluorescence can reach the maximum quenching, which is about 94.3%. From figure 1 It can be seen that nitrogen, nitrogen'-dipyrenebutyryl lysine showed high sensitivity to lead ions, an...

Embodiment 3

[0063] Lead Ion Precipitation Method Based on Nitrogen, Nitrogen'-Dipyrenebutyryllysine

[0064]Add nitrogen, nitrogen'-dipyrenebutyryl lysine solution into the solution containing lead ions, stir until no white flocculent precipitate is formed, which means the precipitation is complete, and centrifuge the suspension at 10000r / min for 5min , carrying out solid-liquid separation, the separated solid is the precipitation of nitrogen, nitrogen'-dipyrene butyryl lysine and lead ion complexes, and the obtained liquid is the solution from which lead ions have been removed. The results of ICP experiments show that nitrogen, nitrogen'-dipyrenebutyryl lysine has a removal rate of more than 94% for lead ions in solution. In the above-mentioned operation, the addition amount of nitrogen, nitrogen '-dipyrene butyryl lysine solution is so far that the lead ion precipitation in the solution can be made completely.

[0065] Of course, in addition to centrifugation, other methods such as fil...

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Abstract

The invention discloses N,N'-dipyrene butyryl lysine serving as a novel compound and a preparation method thereof. The chemical formula of the N,N'-dipyrene butyryl lysine is shown as a formula I shown in the specifications. The invention further discloses application of the N,N'-dipyrene butyryl lysine as a lead ion fluorescent probe and a lead ion precipitant. The invention further discloses a lead ion concentration detection method based on specific recognition of N,N'-dipyrene butyryl lysine and lead ions. The invention discloses a method for recovering the N,N'-dipyrene butyryl lysine. The N,N'-dipyrene butyryl lysine can be conveniently prepared into an aqueous solution, is convenient to operate and has high accuracy when applied to lead ion concentration detection, and can be precipitated together with lead ions in the aqueous solution to realize separation of the lead ions. Moreover, the method for recovering the N,N'-dipyrene butyryl lysine is easy, does not influence the environment, and is convenient to popularize and apply.

Description

technical field [0001] The present invention relates to a kind of new compound nitrogen, nitrogen '-dipyrene butyryl lysine and application thereof. Background technique [0002] Incidents such as "blood lead", "arsenic poisoning", "cadmium rice" and "chromium residue" have occurred frequently, making heavy metal pollution one of the most concerned public events. my country's 12th Five-Year Plan for Comprehensive Prevention and Control of Heavy Metal Pollution issued in 2011 shows that China will focus on the prevention and control of heavy metals such as lead, mercury, cadmium, and chromium. Heavy metal pollution has always been a very serious environmental problem. After they enter the environment, they will not be quickly decomposed in the environment like organic pollutants, but will remain in the environment for a long time, resulting in enduring pollution. At the same time, these pollution sources can enter the human body through the food chain to generate enrichment,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C233/51C07C231/12C07C231/24G01N21/64
Inventor 马立军曹伟光严玉华刘佳伦
Owner SOUTH CHINA NORMAL UNIVERSITY
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