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Dentifrice composition

A composition and dentifrice technology, applied in the fields of medical science, dentistry, oral care, etc., can solve the problems of not obtaining satisfactory results, reduce pathogenic bacteria, etc., and achieve good use feeling, high bactericidal power, smoothness Excellent effect

Active Publication Date: 2012-05-16
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, through more in-depth research by the applicant, it has been found that ascorbyl phosphate or its salt is combined with vitamin E or its derivatives, or ε-aminocaproic acid and / or tranexamic acid, although it has been identified that it has a certain effect on preventing periodontal disease. effect, but no satisfactory effect was obtained for reducing the number of pathogenic bacteria as the main cause

Method used

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  • Dentifrice composition
  • Dentifrice composition
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Examples

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Embodiment

[0063] Hereinafter, the present invention will be specifically described by way of experimental examples, examples, comparative examples, and formulation examples, but the present invention is not limited to the following examples. In addition, in the following examples, any of the % symbols means mass % unless otherwise specified.

[0064] In addition, the dentifrice composition of the composition shown in Tables 1-4 was prepared according to the following manufacturing method.

[0065] The method of manufacture of the dentifrice composition:

[0066] (1) Mix and dissolve water-soluble ingredients (except binder and propylene glycol) in pure water at room temperature to prepare Phase A.

[0067] (2) Disperse the binder in propylene glycol at room temperature to prepare Phase B.

[0068] (3) Add and mix phase B into phase A under stirring to prepare phase C.

[0069] (4) Use a 6L kneader (manufactured by Ishiyama Works) at room temperature to mix ingredients other than wate...

experiment example 1

[0079] [Experimental example 1] Evaluation of bactericidal power after storage at 40°C for 6 months

[0080] After preparing the dentifrice composition (toothpaste) shown in Tables 1-4, it preserved in 40 degreeC thermostat for 6 months. After storage, place until it reaches normal temperature, measure 10 g of each dentifrice composition, add human oral saliva (30 mL), stir and centrifuge (10,000 rpm, 20 min), and take the supernatant as the sample stock solution. Disperse the pre-cultured oral bacteria dispersion (Fusobacterium nucleatum) in human oral saliva, and make the turbidity (OD 660 ) adjusted to 2mL of the solution at 1 o'clock, after acting for 30 seconds, 50 μL was taken as a sample for bactericidal evaluation, and the bactericidal effect was evaluated according to the following method.

[0081] Bactericidal power evaluation:

[0082] Each bactericidal activity evaluation sample solution (50 μL) was added to THB liquid medium (4 mL), and after incubating at 37° C...

experiment example 2

[0089] [Experimental Example 2] Storage stability of magnesium ascorbyl-2-phosphate (hereinafter abbreviated as APM), sodium ascorbyl-2-phosphate (hereinafter abbreviated as APS) or sodium ascorbate after storage at 40°C for 6 months

[0090] After preparing the dentifrice compositions shown in Tables 1 to 4, they were stored in -5°C and 40°C thermostats for 6 months. Samples stored at -5°C were used as non-decomposed controls. After this was left to return to normal temperature, it was used for the evaluation of the storage stability of APM, APS, or sodium ascorbate, and averaged according to the following method. All the reagents were manufactured by Kanto Chemical Co., Ltd.

[0091] Quantification of APM or APS:

[0092] Weigh 0.1g of each dentifrice composition, add 10mmol / L phosphate buffer solution (1.5mmol / L potassium dihydrogen phosphate, 23.5mmol / L dipotassium hydrogen phosphate, pH 8.0), and stir vigorously with an oscillator for 20 minutes , and set the volume to...

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Abstract

Disclosed is a dentifrice composition which is characterized by containing (A) an ascorbic acid phosphate ester or a salt thereof, (B) isopropylmethylphenol, (C) one or more nonionic surfactants selected from among polyoxyethylene alkyl ethers having an alkyl group with 14-18 carbon atoms and an average mole number of added ethylene oxide units of 2-20 and polyoxyethylene-hardened caster oils having an average mole number of added ethylene oxide units of 5-30, (D) a chelating agent and (E) an alkaline agent. The dentifrice composition is also characterized by having a mass ratio (D) / (A) of 0.10-4.0 and an initial pH at 25 DEG C of 8.0-9.3. The dentifrice composition exhibits excellent preventive effects on gingivitis and halitosis even after long storage, while having an excellently smooth composition surface. The dentifrice composition is almost free from unpleasant taste and has good feeling of use, while being effective for prevention or amelioration of periodontal diseases.

Description

technical field [0001] The present invention relates to a dentifrice composition which has an excellent gingivitis preventive effect and a bad breath preventive effect, and is excellent in both the smoothness of the composition surface and the taste during use. Background technique [0002] Periodontal disease is an infection caused by bacteria dominated by obligate anaerobic Gram-negative bacilli such as Porphyromonas gingivalis (P.gingivalis). In addition, bacteria in the oral cavity such as Clostridium nucleatum (F. nucleatum) are involved as a cause of bad breath. Therefore, as an effective method for preventing and improving periodontal disease and bad breath, it is considered effective to control plaque, that is, maintain the number of pathogenic bacteria in the oral cavity at a low level. [0003] As a method of reducing the number of pathogenic bacteria in the oral cavity in this way, it has been effective to mix a poorly water-soluble bactericide or a cationic bact...

Claims

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Application Information

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IPC IPC(8): A61K8/19A61K8/24A61K8/34A61K8/362A61K8/39A61K8/67A61K8/86A61Q11/00
CPCA61K8/347A61Q11/00A61K8/671A61K8/86A61K8/922A61K8/55A61K8/39A61K8/365
Inventor 近泽贵士天野步宇野大介
Owner LION CORP
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