Pharmaceutical-grade calcium chloride production process

A production process, calcium chloride technology, applied in the direction of calcium/strontium/barium chloride, calcium/strontium/barium halide, etc., can solve the problems of irregular product shape and small output.

Inactive Publication Date: 2012-05-30
JIANGSU QINFEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The output of this method is small, and the shape of the product is irregular

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Production of Pharmaceutical Grade Calcium Chloride:

[0015] Take 10kg of light calcium carbonate and put it into pure water, stir, precipitate, and centrifuge. Take the precipitate and add 23L of concentrated hydrochloric acid, and adjust the pH value to 4-5 with calcium carbonate. Settle after boiling, cool to about 20-60°C, take the supernatant and filter. Add pre-prepared lime slurry to this solution to adjust the pH value to 9-11, decolorize with activated carbon, and filter after precipitation. Use hydrochloric acid to adjust the pH value to 4-6, and finely filter. Put the material liquid into a titanium evaporating dish and evaporate until the surface of the solution becomes a paste, stop evaporating, stir, cool and crystallize. After crushing the crystals, put them into a vacuum oven and dry them at 120-150°C; 14.185kg of the product calcium chloride dihydrate is obtained regardless of losses.

Embodiment 2

[0017] The preparation method of medicinal sodium chloride provided by the invention, its quality control standard is based on "Chinese Pharmacopoeia 2010 edition (two)" and enterprise standards. The standards are as follows:

[0018] 1. Properties: This product is white, hard fragments or granules; odorless, slightly bitter taste; easily deliquescent. This product is very soluble in water and soluble in ethanol.

[0019] 2. Identification: The aqueous solution of this product shows the identification reaction of calcium salt and chloride (Appendix III).

[0020] 3. pH: take 3.0g of this product, add 20mL of water to dissolve, add 2 drops of acetic acid phthalein indicator solution; if it appears pink, add 0.30mL of hydrochloric acid titration solution (0.02mol / L), the pink color should disappear; if no color develops , add sodium hydroxide titration solution (0.02mol / L) 0.10mL, it should be pink.

[0021] 4. The clarity of the solution Take 1.0g of this product, add 10mL o...

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PUM

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Abstract

The invention relates to a pharmaceutical-grade calcium chloride production process, which comprises 1) soaking light calcium carbonate in pure water, dewatering by a sedimentation centrifuge and collecting the precipitate; 2) adding the washed light calcium carbonate into a reactor, neutralizing by hydrochloric acid to obtain subacidity, preparing 40% calcium chloride solution, boiling, precipitating while keeping at a given temperature for a few hours, filtering, adjusting pH to 9-11 by lime water, precipitating for a few hours, filtering, adjusting pH to 3-5 by hydrochloric acid and precisely filtering; 3) evaporating the solution until a thin film appears at the surface of the solution, cooling for a while and stirring for crystallizing; and 4) breaking the crystal, putting into a vacuum oven, and heating for drying to obtain calcium chloride dihydrate with uniform particle size.

Description

technical field [0001] The invention relates to a production process of calcium chloride, in particular to a production process of pharmaceutical grade calcium chloride. Background technique [0002] Calcium chloride is a commonly used calcium supplement, and it is also used to regulate the electrolyte balance of the human body. Its administration forms include oral administration, injection, and hemodialysis. [0003] Calcium chloride dihydrate for food and industry is the distillation waste liquid in the production of soda ash by the ammonia-alkali method. After purification, clarification, and evaporation, when the calcium chloride content reaches about 40%, the calcium chloride is separated, and the filtrate is passed through After clarification, it is sent to the evaporator to continue to concentrate, and it is cooled to obtain calcium chloride dihydrate. This method has a high concentration of impurities and cannot be used for pharmaceuticals. [0004] In the product...

Claims

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Application Information

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IPC IPC(8): C01F11/28
Inventor 梁全超朱海林童海英
Owner JIANGSU QINFEN PHARMA
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