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A kind of medicine for treating diabetes and preparation method thereof

A technology for dispersible tablets and ginseng, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of difficulty in rational drug use, obstructed blood sugar flow, and difficulty in starting, and achieves improved bioavailability and reduced dosage. and toxic side effects, the effect of preventing hypoglycemia

Active Publication Date: 2014-10-29
JILIN JICHUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most patients with diabetes will have disorders of blood sugar metabolism and blood lipid metabolism. Because the pathways of glycolysis, glycogen synthesis and lipogenesis in the liver are not easy to start, the outlet of blood sugar is blocked.
New oral hypoglycemic drugs are constantly on the market, which provides conditions for clinical treatment and also brings certain difficulties to rational drug use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Weigh 130g of raw materials ginseng, 425g of astragalus, 730g of Digupi, 275g of Pueraria radix, 275g of Anemarrhena, 275g of Chinese yam, 350g of trichosanthin, 220g of schisandra, 125g of gallinaceous gold, and 260g of corn silk.

[0042] The amount of auxiliary materials added to the dispersible tablet is based on the weight of the superfine powder of the main drug, adding calcium sulfate 30%, cross-linked polyvinylpyrrolidone 4%, 10% polyvinylpyrrolidone K30 aqueous solution 2%, Tween-80 0.2%, micronized silica gel 2% . The amount of micropellet auxiliary materials added is based on the weight of the main drug ointment powder, and 20% of microcrystalline cellulose is added.

[0043] Preparation of dispersible tablets: ultrafine grinding of the above-mentioned ginseng; reflux extraction of pueraria root and schisandra with 75% ethanol three times, each time for 1.5 hours, combined extracts, filtered, and medicinal liquid for later use; Astragalus, Digupi, Anemarrhena...

Embodiment 2

[0046] Weigh 140g of raw materials ginseng, 435g of astragalus, 740g of digupi, 285g of kudzu root, 285g of anemarrhena, 285g of yam, 360g of trichosanthin, 230g of schisandra, 135g of gallinaceous gold, and 270g of corn silk.

[0047] The amount of auxiliary materials added to the dispersible tablet is based on the weight of the superfine powder of the main drug, adding calcium sulfate 40%, cross-linked polyvinylpyrrolidone 6%, 10% polyvinylpyrrolidone K30 aqueous solution 4%, Tween-80 0.4%, micronized silica gel 4% ; The amount of micropellet supplementary materials is based on the weight of the main ointment powder, and 30% of microcrystalline cellulose is added. The preparation method of its dispersible tablets and sustained-release pellets is the same as in Example 1.

Embodiment 3

[0049] Weigh 150g of raw materials ginseng, 445g of astragalus, 750g of digupi, 295g of pueraria radix, 295g of anemarrhena, 295g of Chinese yam, 370g of trichosanthin, 240g of schisandra, 145g of gallinaceous gold, and 280g of corn silk.

[0050] The amount of auxiliary materials added to the dispersible tablet is based on the weight of the superfine powder of the main drug, adding calcium sulfate 50%, cross-linked polyvinylpyrrolidone 8%, 10% polyvinylpyrrolidone K30 aqueous solution 6%, Tween-80 0.6%, micronized silica gel 6% ; The amount of micropellet auxiliary materials is based on the weight of the main ointment powder, and 40% of microcrystalline cellulose is added. The preparation method of its dispersible tablets and sustained-release pellets is the same as in Example 1.

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Abstract

The invention relates to a medicine for treating diabetes and specifically to a Chinese patent medicine prepared from Chinese herbal medicines and a preparation method thereof. The medicine is prepared from the following bulk drugs by weight: 130 to 180 g of ginseng, 425 to 475 g of radix astragali, 730 to 780 g of cortex lycii, 275 to 325 g of root of kudzu vine, 275 to 325 g of anemarrhena, 275 to 325 g of Chinese yam, 350 to 400 g of trichosanthes root, 220 to 270 g of Chinese magnoliavine, 125 to 175 g of chicken's gizzard membrane and 260 to 310 g of corn silk. The preparation method comprises the following steps: weighing the bulk drugs according to a weight ratio, carrying out micro grinding, ethanol reflux extraction, water decoction and filtration on the bulk drugs, merging soup, carrying out condensation, uniform mixing, drying and ultramicro grinding on the merged soup so as to obtain main drug submicron powder and uniformly mixing the submicron powder with accessories so as to prepare dispersing tablets or slow release pellets.

Description

technical field [0001] The invention relates to a medicine for treating diabetes, in particular to a Chinese patent medicine prepared from Chinese herbal medicines. The invention also relates to a preparation method of the medicine. Background technique [0002] Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia caused by defects in insulin secretion and (or) action. The various complications caused by it have become one of the main causes of disability and premature death of patients. In developed countries, the number of deaths caused by complications of diabetes ranks third after cardiovascular and cerebrovascular diseases and cancer. So far, diabetes is still a disease that is difficult to cure at one time. In addition to controlling patients with diet and exercise therapy, oral hypoglycemic drugs play an important role in the treatment of diabetes. About 70% of diabetic patients need to take long-term hypoglycemic agents. Sugar ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P3/10A61K35/37A61K35/57
Inventor 曲风采
Owner JILIN JICHUN PHARMA
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