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Formula of novel docosahexaenoic acid (DHA) fat emulsion preparation and preparation method thereof

An emulsion and fat technology, which is applied in the direction of oil/fat/wax non-active ingredients, emulsion delivery, nervous system diseases, etc., can solve the problems of low content of active ingredients, low bioavailability, short shelf life, etc., to extend the shelf life , enhanced therapeutic effect, good stability effect

Active Publication Date: 2014-02-12
XIAN LIBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After research, we found that the existing preparations have problems such as poor stability, short shelf life, low content of active ingredients, poor absorption, and low bioavailability

Method used

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  • Formula of novel docosahexaenoic acid (DHA) fat emulsion preparation and preparation method thereof
  • Formula of novel docosahexaenoic acid (DHA) fat emulsion preparation and preparation method thereof
  • Formula of novel docosahexaenoic acid (DHA) fat emulsion preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: the ratio of DHA and diluent oil (the weight ratio of DHA: soybean oil is 1: 1)

[0046] Prescription:

[0047]

[0048] Take 70.0g of DHA, 3.0g of vitamin E, 70.0g of refined soybean oil, add 12.5g of lecithin, heat and stir for about 10-20min to mix well. Another 700ml of water for injection was taken, and 22.0g of glycerin was added. Under the condition of nitrogen protection and stirring, the DHA phospholipid oil solution was added to the aqueous glycerin solution, and the total amount was adjusted to 1000ml. Homogenize 7-8 times with a high-pressure homogenizer, the homogenization pressure is 100MPa, until the particle size ranges from 180nm-300nm, adjust the pH to 7.0-8.0, filter, subpackage, inject nitrogen, and seal. Sterilize at 115°C for 30 minutes, and pack after passing the light inspection. Store below 25°C.

Embodiment 2

[0049] Embodiment 2: the ratio of DHA and diluent oil (DHA: the weight ratio of soybean oil is 0.03)

[0050] Prescription:

[0051]

[0052] Take 10.0g of DHA, 3.0g of vitamin E, 330.0g of refined soybean oil, add 12.5g of lecithin, heat and stir for about 10-20min to mix well. Another 700ml of water for injection was taken, and 22.0g of glycerin was added. Under the condition of nitrogen protection and stirring, the DHA phospholipid oil solution was added to the aqueous glycerin solution, and the total amount was adjusted to 1000ml. Homogenize 7-8 times with a high-pressure homogenizer, the homogenization pressure is 100MPa, until the particle size ranges from 180nm-300nm, adjust the pH to 7.0-8.0, filter, subpackage, inject nitrogen, and seal. Sterilize at 115°C for 30 minutes, and pack after passing the light inspection. Store below 25°C.

[0053](2) Inspection of the dosage range of diluent oil

[0054] Under the premise of ensuring that the ratio of DHA to the di...

Embodiment 3

[0055] Embodiment 3: the DHA fat emulsion preparation (diluted oil content 5%, weight content) of minimum soybean oil content

[0056] Prescription:

[0057]

[0058] Take 10.0g of DHA, 3.0g of vitamin E, 300.0g of refined soybean oil, add 12.5g of lecithin, heat and stir for about 10-20min to mix well. Another 600ml of water for injection was taken, and 22.0g of glycerol was added. Under the condition of nitrogen protection and stirring, the DHA phospholipid oil solution was added to the aqueous glycerin solution, and the total amount was adjusted to 1000ml. Homogenize 7-8 times with a high-pressure homogenizer, the homogenization pressure is 100MPa, until the particle size ranges from 180nm to 300nm, adjust the pH to 7.0-8.0, filter, sub-package, inject nitrogen, and seal. Sterilize at 115°C for 30 minutes, and pack after passing the light inspection. Store below 25°C.

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Abstract

The invention discloses a formula of a novel docosahexaenoic acid (DHA) fat emulsion preparation and a preparation method thereof. The novel preparation main comprises DHA, an emulsion, soybean oil or other refined oil as an oil-soluble diluent, oleic acid or oleate as auxiliary emulsification, vitamin E or a vitamin E derivative as antioxidation, an ion chelating agent and glycerol or micromolecule sugar as an isotonic adjusting agent. A variety of methods are used alone or are used together to prepare the DHA fat emulsion preparation.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a fat emulsion preparation and a preparation method thereof, in particular to a novel DHA fat emulsion preparation and a preparation method thereof. Background technique [0002] DHA, docosahexaenoic acid, commonly known as brain gold, is a polyunsaturated fatty acid that is very important to the human body and is an important member of the Omega-3 unsaturated fatty acid family. [0003] DHA is an essential component of the brain, accounting for about 10% of human brain fat, and is extremely beneficial to the growth and development of brain nerve conduction and synapses. Cognitive decline is associated with DHA deficiency (1). The cerebral cortex of patients with major depression has almost no DHA (2). DHA can prevent the deposition of cholesterol on the blood vessel wall, thereby preventing or reducing the occurrence of atherosclerosis and coronary heart disease. For adolescents entering...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/202A61K47/34A61K47/44A61P25/00
Inventor 余维平陈涛王汝涛
Owner XIAN LIBANG PHARMA
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