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Cefprozil pharmaceutical composition

A technology of cefprozil and composition, applied in the field of medicine, can solve the problem that the hardness of the tablet is difficult to meet the requirements of packaging and transportation, and achieve the effects of excellent dispersion uniformity, release property and excellent hardness

Active Publication Date: 2016-12-14
GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the dispersion uniformity is qualified, the hardness of the tablet is difficult to meet the requirements of packaging and transportation

Method used

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  • Cefprozil pharmaceutical composition
  • Cefprozil pharmaceutical composition
  • Cefprozil pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Dispersible tablets containing 250 mg of cefprozil (calculated as anhydrous substance) as the non-micronized active compound, the cefprozil active compound accounting for about 74% of the total tablet weight:

[0048] Cefprozil (as anhydrous substance) 250mg

[0049] Microcrystalline Cellulose 57mg

[0050] Pregelatinized starch 10mg

[0051] 3% hypromellose 50% alcohol solution 100ml

[0052] Crospovidone 17mg

[0053] Magnesium Stearate 3mg

[0054]Preparation method: Cefprozil, pregelatinized starch, microcrystalline cellulose, 40% crospovidone (6.8mg), granulate with the hypromellose ethanol solution, dry, then add the remaining crospovidone Lupovidone, Magnesium Stearate, Blended, Tabletted.

Embodiment 2

[0056] Dispersible tablets containing 250 mg of cefprozil (calculated as anhydrous substance) as the non-micronized active compound, the cefprozil active compound accounting for about 68% of the total tablet weight:

[0057] Cefprozil (as anhydrous substance) 250mg

[0058] Microcrystalline Cellulose 91.2mg

[0059] Pregelatinized Starch 4mg

[0060] 3% hypromellose 50% alcohol solution 100ml

[0061] Crospovidone 11mg

[0062] Magnesium Stearate 1.8mg

[0063] Preparation method: add 5.5 mg of crospovidone first (accounting for 50% of the total weight of crospovidone), and the others are the same as in Example 1.

Embodiment 3

[0065] Dispersible tablets containing 250 mg of cefprozil (calculated as anhydrous substance) as non-micronized active compound, the cefprozil active compound accounting for about 80% of the total tablet weight:

[0066] Cefprozil (as anhydrous substance) 250mg

[0067] Microcrystalline Cellulose 32mg

[0068] Pregelatinized Starch 4mg

[0069] 2% hypromellose 50% alcohol solution 80ml

[0070] Crospovidone 12mg

[0071] Magnesium Stearate 4mg

[0072] Preparation method: add 4.2 mg of crospovidone first (accounting for 35% of the total weight of crospovidone), and the others are the same as in Example 1.

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PUM

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Abstract

The invention relates to an anti-infective oral pharmaceutical preparation, and discloses a cefprozil pharmaceutical composition, comprising cefprozil as an active ingredient, and at least one filler, at least one disintegrant, at least one lubricant, and at least one lubricant based on its weight Contains 1-10% pregelatinized starch, 0.5-2% hypromellose. The invention also relates to the preparation method of the preparation and the application in the treatment of upper respiratory tract infection, lower respiratory tract infection, skin and skin and soft tissue infection.

Description

technical field [0001] The invention relates to an oral pharmaceutical composition for treating upper respiratory tract infection, lower respiratory tract infection, skin and skin soft tissue infection, in particular to a pharmaceutical preparation containing cefprozil, pregelatinized starch, hypromellose and its The preparation method belongs to the technical field of medicine. Background technique [0002] Cefprozil is an antibacterial drug with the following structural formula: [0003] [0004] (6R,7R)-7-[(R)-2-amino-2-(p-hydroxy-phenyl)acetamido]-8-oxo-3-propene-5-thia-1-azabicyclo- (4,2,0)oct-2-ene-2-carboxylic acid monohydrate. [0005] This is a second-generation oral cephalosporin antibiotic with high efficiency, low toxicity, and enzyme resistance. It has strong antibacterial activity against Gram+ bacteria, Gram-bacteria, and anaerobic bacteria, especially anti-G+ bacteria. Coccus, Streptococcus pyogenes, and Staphylococcus aureus have stronger antibacterial...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/545A61K9/20A61P11/00A61P17/00
Inventor 陈矛朱少璇肖颖杨放
Owner GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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