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Artificial skin and preparation method thereof

A technology of artificial skin and epidermis, applied in medical science, prosthesis, etc., can solve problems such as skin induction and regeneration, and achieve the effect of promoting healing, controlling evaporation, and isolating germs

Active Publication Date: 2012-07-04
RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there are still great challenges in how to achieve skin-induced regeneration clinically.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0020] The preparation method of the double-layer artificial skin with piezoelectric conductivity of the present invention mainly includes the following steps:

[0021] Step 1, prepare the microporous membranous epidermis: dissolve PVDF, PVDF and / or PVDF-TrFE with a certain organic solvent, seal them in a container filled with protective gas, fully dissolve them in an oven at a certain temperature, and then heat the Pour out the solution, place it on a stainless steel sheet or glass sheet at the same high temperature, cool down or quench naturally, PVDF and / or PVDF-TrFE can phase separate with the solvent, crystallize, and form a film; then the film is washed repeatedly to remove organic matter. solvent, and the microporous membranous epidermis is prepared by drying.

[0022] Step 2, conduct polarization treatment of the epidermis: put the microporous membranous epidermis prepared in step 1 into silicone oil at a certain temperature, cover the upper and lower sides of the epid...

example 1

[0029] The described double-layer artificial skin with piezoelectric conductivity specifically comprises the following steps:

[0030](1) Use benzophenone and dimethyl phthalate compound solvent (volume ratio 8:1) to dissolve PVDF. Fully dissolve in an oven at 200°C, then pour out the high-temperature solution, place it on a stainless steel sheet at the same high temperature, quench, PVDF and solvent undergo phase separation, crystallization, and film formation; then the film is repeatedly washed to remove the organic solvent, after Drying prepares a microporous membranous epidermis. Then, the organic solvent is repeatedly washed by washing with diethyl ether and then with ethanol, and the microporous membranous epidermis is prepared by drying.

[0031] (2) Carry out polarization treatment of the epidermis, that is, put the microporous membranous epidermis prepared in step (1) into silicone oil at 120°C, cover the upper and lower sides of the epidermis with silver electrodes,...

example 2

[0034] The described double-layer artificial skin with piezoelectric conductivity specifically comprises the following steps:

[0035] (1) Use benzophenone and dimethyl phthalate composite solvent (9:1) to dissolve PVDF and PVDF-TrFE (mass ratio 4:1), the mass volume ratio concentration of the dissolved solute is 30%, airtight In a container filled with helium, place it in an oven at 240°C to fully dissolve, then pour out the high-temperature solution, place it on a stainless steel sheet at the same high temperature, quench, and the solute PVDF and PVDF-TrFE will separate from the solvent and crystallize , forming a film; then the film is repeatedly washed to remove the organic solvent, and dried to prepare a microporous film-like epidermis. Then, the organic solvent is repeatedly washed by washing with diethyl ether and then with ethanol, and the microporous membranous epidermis is prepared by drying.

[0036] (2) Then carry out the polarization treatment of the epidermis, t...

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Abstract

The invention relates to artificial skin, which is formed by compounding a microporous membrane epidermal layer with piezoelectric conducting performance and a natural high polymer bionic skin corium, wherein the microporous membrane epidermal layer mainly comprises polyvinylidene fluoride and / or a polymer thereof, i.e., polyvinylidene fluoride-trichloroethylene; and the skin corium is a collagen membrane. The preparation method mainly comprises the following steps of: preparing the microporous membrane epidermal layer; polarizing the epidermal layer; and compounding a dermal scaffold and preparing double-layer artificial skin. In the use process of the artificial skin, electric stimulation of which the strength is similar to that of bioelectricity can be generated after binding and extruding, so that healing of a skin wound is facilitated. Meanwhile, the epidermal layer of the artificial skin has a microporous structure of which the size is smaller than those of pathogenic bacteria, so that pathogenic bacteria can be isolated effectively, and infection is prevented; and meanwhile, evaporation of wound moisture can be controlled effectively, and high air permeability and flexibility are achieved.

Description

technical field [0001] The invention belongs to the field of bioactive materials, in particular to an artificial skin with piezoelectric conductivity and a preparation method thereof. Background technique [0002] Bioelectricity is a common phenomenon in organisms. Various life activities in organisms are accompanied by electrical phenomena and are closely related to the metabolism of the organism. The generation of electrical phenomena in organisms is due to the transcellular ion flow that can generate transcellular potentials. When there is a defect in the cell layer or the resistance of the tight junction between cells is reduced, the cell potential drives the current to flow out from these areas, forming an electric field. Basic features of life activities. Current studies have shown that a variety of cells can respond to endogenous or external electric fields. Studies have shown that endogenous electric fields exist near tissue damage areas, and cells can undergo biolo...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/60A61L27/56
Inventor 王明波佘振定谭荣伟刘伟强张文强李丽花
Owner RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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