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Sugarless gingkgo oral liquid and preparation method and detection method thereof

A detection method and technology of oral liquid, applied in the field of traditional Chinese medicine, can solve problems such as unavailable effects, inability to ensure drug quality and curative effect, prescription dosage, immature preparation process, etc.

Active Publication Date: 2014-03-26
ZHEJIANG DADE PHARMACEUTICAL GROUP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although there have been related reports on the preparation of medicines for treating bronchitis and asthma by combining Ginkgo biloba and saponica, the technical research on the dosage and preparation technology of the prescriptions is not mature enough, and no effective medicinal products have been produced yet.
Moreover, there is no corresponding quality testing method for the drug, which cannot ensure the quality and efficacy of the drug

Method used

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  • Sugarless gingkgo oral liquid and preparation method and detection method thereof
  • Sugarless gingkgo oral liquid and preparation method and detection method thereof
  • Sugarless gingkgo oral liquid and preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0159] Embodiment 1 of the present invention: the preparation of sugar-free ginkgo oral liquid:

[0160] Take 476.2g of ginkgo kernels, 714.3g of fennel, 1.8g of stevia, 0.1mL of almond essence, 0.03g of menthol and 1g of sorbic acid. First the ginkgo nuts are smashed, according to the percolation method (Appendix 10 of Chinese Pharmacopoeia 2005 edition) under the liquid extract and the extract item, use 7 times the amount of 60% ethanol as solvent, carry out percolation, and the ethanol is reclaimed from the percolation liquid. Concentrate into a clear paste with a relative density of 1.02-1.07 (55-65°C), let it stand, separate layers, filter, and use the filtrate for later use; add 10 times and 8 times the amount of water to boil twice for 2 hours each time. , combined the decoction, filtered, the filtrate was concentrated into a clear paste with a relative density of 1.17-1.22 (55-65°C), cooled and mixed with an equal amount of ethanol, left for 24 hours, filtered, the fil...

Embodiment 2

[0161] Embodiment 2 of the present invention: the preparation of sugar-free ginkgo oral liquid:

[0162] Take 500g of ginkgo kernels, 750g of lentils, 2g of stevia, 0.12mL of almond essence, 0.04g of menthol and 1.2g of sorbic acid. First the ginkgo nuts are smashed, according to the percolation method (an appendix 10 of Chinese Pharmacopoeia 2005 edition) under the liquid extract and the extract item, use 60% ethanol as solvent, carry out percolation, and the percolation liquid reclaims ethanol and concentrates into relative Clear the paste with a density of 1.05 (55-65°C), let it stand, separate layers, filter, and use the filtrate for later use; add 10 times the amount and 8 times the amount of water to decoct the spinach twice, each time for 2 hours, and combine the decoctions. Filtrate, concentrate the filtrate into a clear paste with a relative density of 1.20 (55-65°C), add an equal amount of ethanol to mix evenly after cooling, let it stand for 24 hours, filter, recove...

Embodiment 3

[0163] Embodiment 3 of the present invention: the detection method of sugar-free ginkgo oral liquid comprises the following items:

[0164]Properties: This preparation is light brown to tan liquid; fragrant and sweet.

[0165] Identification: Take 10mL of this oral liquid preparation, add 2g of sodium chloride, stir to dissolve, extract twice with chloroform, 25mL each time, combine the chloroform solutions, evaporate to dryness on a water bath (about 70°C), add 1mL of ethyl acetate to make Dissolve, filter, and make a filtrate as the test solution; take another 3 g of the reference herbal medicine, add water and decoct twice, each time for 30 minutes, filter while hot, combine the filtrates, concentrate to about 10 mL, let cool, According to the preparation method of the aforementioned test solution, from "extracting twice with chloroform", a contrast medicinal material solution was made; according to the thin-layer chromatography (Chinese Pharmacopoeia, 2000 edition, an appe...

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Abstract

The invention discloses sugarless gingkgo oral liquid, a preparation method thereof and a detection method thereof. The sugarless gingkgo oral liquid is prepared from the following components in part by weight: 450 to 500 parts of ginkgo seeds, 700 to 750 parts of rorippa, 1.5 to 2 parts of steviosin, 0.8 to 1.2 parts of sorbic acid, proper amount of almond essence and proper amount of menthol. Compared with the prior art, the sugarless preparation disclosed by the invention has the advantages of high bioavailability and stability; the limitation of medicaments applied to diabetic patients is overcome; the group to which the sugarless preparation is applied is widened; the sugarless preparation is clear in treatment effect on acute and chronic bronchitis, chronic cough and asthma, unsmooth expectoration and the like; and the preparation does not contain any addictive components, does not have toxic and side effects, and is good in mouth feeling, quick in effect and convenient to take. In addition, the detection method is high in precision degree, good in reproducibility and accurate in detection result. The clinical treatment effect of the preparation can be effectively ensured.

Description

technical field [0001] The invention relates to a sugar-free ginkgo oral liquid, a preparation method and a detection method thereof, and belongs to the technical field of traditional Chinese medicines. Background technique [0002] Cough is the main symptom of respiratory system diseases, such as cough without sputum or sputum volume is dry cough, which is common in the early stage of acute pharyngitis and bronchitis; acute cough is more common in bronchial foreign bodies; long-term chronic cough is more common in Chronic bronchitis, tuberculosis, etc. Coughing can spread tracheal lesions to adjacent small bronchi, making the condition worse. In addition, long-lasting and severe cough will affect the rest, and it is easy to consume physical strength, and can cause damage to the elastic tissue of the alveolar wall, and induce emphysema. According to the "Compendium of Materia Medica": "Ginkgo biloba, sweet and bitter, flat and astringent, enters the lung meridian. It is fa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/36G01N30/90A61K36/31A61P11/06A61P11/10A61P11/14
Inventor 王建国陈法贵徐丽君
Owner ZHEJIANG DADE PHARMACEUTICAL GROUP CO LTD
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