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Oil-in-water compound juniper berry oil nanoemulsion composition and preparation method thereof

A juniper berry oil and oil-in-water technology, applied in the field of medicine, can solve problems such as single action and many adverse reactions, and achieve the effects of strong local action, clear and transparent appearance, and high content of active ingredients

Inactive Publication Date: 2012-07-11
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the antibacterial drugs used clinically mainly include western medicines, which not only have a single effect, but also have many adverse reactions, and with their widespread use, the problem of drug resistance has become a problem that cannot be ignored.

Method used

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  • Oil-in-water compound juniper berry oil nanoemulsion composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] 1) Weigh 10.2g of RH-40, 20.0g of Tween-80, 1.9g of absolute ethanol, 6.5g of juniper berry oil, 2.2g of chamomile oil, 1.5g of eucalyptus oil, 1.2g of tea tree oil, and distilled water according to the formula ratio 56.5g, spare;

[0055] 2) Stir the stated amount of juniper oil, chamomile oil, eucalyptus oil and tea tree oil evenly to make

[0056] is the oil phase;

[0057] 3) Add the amount of surfactant and co-surfactant into the oil phase and mix well;

[0058] 4) Use distilled water as the water phase, stir the oil phase quickly at room temperature, slowly add the water phase dropwise while stirring, and keep stirring until the system becomes a transparent liquid, and the oil-in-water compound juniper oil nanoemulsion composition is obtained.

Embodiment 2

[0060] Tween-80 20.0g, EL-40 13.2g, isopropanol 0.3g, juniper oil 1.8g, chamomile oil 0.7g, eucalyptus oil 0.2g, tea tree oil 0.8g, distilled water 63.0g.

Embodiment 3

[0062] EL-40 30.3g, absolute ethanol 1.5g, juniper berry oil 5.7g, chamomile oil 2.3g, eucalyptus oil 1.9g, tea tree oil 1.5g, distilled water 56.8g.

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Abstract

The invention discloses an oil-in-water compound juniper berry oil nanoemulsion composition, which is characterized in that the particle diameter of nanoemulsion is 1-100nm. The oil-in-water compound juniper berry oil nanoemulsion composition comprises the following raw materials in percentage by mass: 25.0-35.0% of surfactant, 0.3-6.0% of cosurfactant, 1.6-10.0% of juniper berry oil, 0.7-5.5% of chamomile oil, 0.2-3.5% of eucalyptus oil, 0.5-4.5% of tea tree oil and the balance distilled water, wherein the sum of the percentage by mass of the above raw materials is 100%. The compound juniper berry oil nanoemulsion composition has the advantages of strong antimicrobial activity, strong permeability, good stability, high effective ingredient content, obvious percutaneous absorption effect, long acting time and good application prospect in the pharmaceutical market, has the efficacies on treating acne, eczema, chronic eczema, dermatitis, pustule, wound and the like, and is convenient to popularize and apply.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a compound juniper berry oil nanoemulsion composition for treating acne, eczema, psoriasis, dermatitis, pustules and wounds and a preparation method thereof. [0002] Background technique [0003] Bacteria and fungi have always surrounded us in our lives, and we are often faced with the choice of antibacterial drugs due to various infectious diseases. At present, the clinically used antibacterial drugs mainly include western medicine, which not only has a single effect, but also has many adverse reactions, and with its widespread use, the problem of drug resistance has become a problem that cannot be ignored. Plants contain many natural medicinal ingredients, which not only have strong antibacterial ability and wide antibacterial spectrum, but also have a wide range of uses, are safe and have no side effects. Contents of the invention [0004] The object of the present invention is to ...

Claims

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Application Information

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IPC IPC(8): A61K36/61A61K47/26A61K47/44A61K9/107A61P17/10A61P17/00A61P31/10A61P17/02
Inventor 欧阳五庆郑星星欧阳伸雨
Owner NORTHWEST A & F UNIV
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