Method for forcedly extracting effective components of Chinese herbal medicine by using magnetic adsorbent under coordination of ultrasonic waves

A technology of magnetic adsorbents and Chinese herbal medicines, applied in medical preparations containing active ingredients, solid adsorbent liquid separation, separation methods, etc., to achieve enhanced extraction rate, efficient extraction, and high extraction rate

Active Publication Date: 2012-07-11
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to provide a novel and efficient method for the enhanced extraction of the effective components of Chinese herbal medicines by ultrasonic and magnetic adsorbents to overcome the defects of the existing extraction methods

Method used

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  • Method for forcedly extracting effective components of Chinese herbal medicine by using magnetic adsorbent under coordination of ultrasonic waves
  • Method for forcedly extracting effective components of Chinese herbal medicine by using magnetic adsorbent under coordination of ultrasonic waves
  • Method for forcedly extracting effective components of Chinese herbal medicine by using magnetic adsorbent under coordination of ultrasonic waves

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Experimental program
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Effect test

Embodiment 1

[0032] Extraction method: Add 30ml of n-hexane to 3g of Salvia miltiorrhiza powder, then add 100mg of magnetic molecularly imprinted microspheres with an average particle size of 200nm, then place the entire container in an ultrasonic extractor, and use circulating cooling water to maintain the extraction temperature at room temperature without stirring Under the influence of ultrasonic extraction for 5 minutes, the sample was magnetically separated, the filtrate obtained by filtering out the Chinese herbal medicine matrix, and the magnetic molecularly imprinted microspheres were desorbed in a mixed solution of methanol: acetic acid (9:1, v / v) to obtain a desorption liquid, and the filtrate and Desorb the liquid to obtain the extract, and the contents of the three active ingredients are detected by high performance liquid chromatography.

[0033] Results: The contents of cryptotanshinone, tanshinone 1 and tanshinone 2a in Danshen were 0.206 mg / g, 0.136 mg / g and 0.461 mg / g, resp...

Embodiment 2

[0037] Extraction method: Add 30ml of n-hexane to 3g of Salvia miltiorrhiza powder, add 100mg of magnetic molecularly imprinted microspheres with an average particle size of 200nm, then place the whole container in an ultrasonic extractor, use circulating cooling water to maintain the extraction temperature at room temperature, without stirring and extract for 10 min, magnetically separate and recover the magnetic microspheres from the sample, filter the Chinese herbal medicine matrix to obtain the filtrate, desorb the magnetic molecularly imprinted microspheres in a mixed solution of methanol:acetic acid (9:1, v / v) to obtain a desorption liquid, and combine The filtrate and the desorbed liquid are used to obtain an extract, and the contents of the three active ingredients are detected by high performance liquid chromatography.

[0038] Results: The contents of cryptotanshinone, tanshinone 1 and tanshinone 2a in Danshen were 0.249mg / g, 0.157mg / g and 0.475mg / g, respectively, by ...

Embodiment 3

[0042] First, mix 1 g of woody powder, 5 mg of magnetic molecularly imprinted polymer microspheres with an average particle size of 10 nm, and 5 g of ethanol, and place them in an ultrasonic extractor for ultrasonic extraction for 1 min, with an ultrasonic power of 500 W, and maintain the extraction temperature with circulating cooling water. At room temperature, it was stirred continuously, and the stirring speed was 2000rpm, and adsorption extraction was carried out; then the magnetic adsorbent was recovered by magnetic separation, the Chinese herbal medicine matrix was filtered to obtain the filtrate, and the magnetic molecularly imprinted polymer microspheres were dissolved in ethanol: acetic acid (3: 1, v / v) desorb to obtain a desorption solution, combine the filtrate and desorption solution to obtain an extract, and detect with high performance liquid chromatography.

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Abstract

The invention relates to a method for forcedly extracting effective components of a Chinese herbal medicine by using a magnetic adsorbent under the coordination of ultrasonic waves. The method comprises the following steps of: firstly, mixing the Chinese herbal medicin, the magnetic adsorbent and an extraction solvent, and placing the mixture in an ultrasonic extractor at room temperature to carry out ultrasonic extraction; then, magnetically separating and recycling the magnetic adsorbent, filtering to obtain filtrate, desorbing the magnetic adsorbent to obtain desorption liquid, and merging the filtrate and the desorption liquid to obtain extraction solution, wherein when the magnetic adsorbent is enough, the filtrate can be ignored, and the desorption liquid is used as the extraction solution. The method has the advantages of simple process, high extraction speed, high extraction ratio, mild extraction condition (room temperature), high selectivity, recyclable solvent, high product extraction purity and the like and is very suitable for the rapid, high-selectivity and efficient extraction of heat sensitive components in a Chinese herbal medicine product.

Description

technical field [0001] The invention relates to the technical field of purification of Chinese herbal medicines, in particular to a method for intensified extraction of effective components of Chinese herbal medicines by ultrasonic waves in cooperation with a magnetic adsorbent. Background technique [0002] As a kind of pure natural herbal medicine, Chinese herbal medicine contains many medicinal ingredients, which can treat many diseases. In order to realize the effective utilization of Chinese herbal medicine, it is necessary to extract these medicinal ingredients from plant tissues, and then further separate and refine them to produce Chinese patent medicines and various preparations, these Chinese herbal preparations are very popular because of their natural nature and few side effects. [0003] In the process of utilizing the active ingredients of Chinese herbal medicine, extraction technology is the key. The traditional extraction method is to use organic solvent ext...

Claims

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Application Information

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IPC IPC(8): B01D11/02B01D15/00A61K36/537A61K36/285A61K36/9068A61K36/752A61K36/284
Inventor 杨良嵘李文松邢慧芳黄寅斌王福春刘会洲
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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