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Preparation method of carboxylic acid betaine modified non-woven fabric for hemofiltration

A technology of blood filtration and non-woven fabrics, applied in the field of biomedical materials, can solve the problems of cumbersome cleaning process, high economic cost, and time-consuming, and achieve the effect of simple preparation process and good blood compatibility

Inactive Publication Date: 2012-07-11
SUZHOU YITONG FILTER TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the cleaning process of blood filter materials is not only cumbersome, but also time-consuming, and the economic cost is high. Therefore, it is imminent to develop efficient, safe and blood-compatible blood filter materials.
[0006] In further searches, no technical reports have been found on the use of carboxylic acid betaine groups to graft and modify non-woven fabrics

Method used

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  • Preparation method of carboxylic acid betaine modified non-woven fabric for hemofiltration
  • Preparation method of carboxylic acid betaine modified non-woven fabric for hemofiltration
  • Preparation method of carboxylic acid betaine modified non-woven fabric for hemofiltration

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Set the areal density to 120g / m 2 , the average fiber diameter is 2.5 μm, the average pore size is 15 μm, the thickness is 1 mm, and the area is 10 × 10 cm 2 The PBT non-woven block was put into a 4% ethanol solution of photosensitizer benzophenone in 80 ml, soaked for 30 minutes, taken out and air-dried to obtain a non-woven fabric coated with photosensitizer on the surface. The non-woven fabric was immersed in 120ml of an aqueous solution of 20% DMAA, and passed through nitrogen for 30 minutes, and then the sample cell was put into an ultraviolet irradiation device with a nitrogen atmosphere to carry out ultraviolet irradiation grafting reaction, and the irradiation time was 30 minute. After the reaction, the non-woven fabric was taken out, placed in ethanol for ultrasonic cleaning for 30 minutes, and then washed with a large amount of water until the washing liquid had no foam and the surface of the non-woven fabric had no greasy feeling. The cleaned samples were p...

Embodiment 2

[0030] Set the areal density to 120g / m 2 , the average fiber diameter is 5 μm, the average pore size is 10 μm, the thickness is 1 mm, and the area is 10 × 10 cm 2 The PP non-woven fabric block was put into 4% 80ml ethanol solution of photosensitizer benzophenone, soaked for 30 minutes, taken out and air-dried to obtain a non-woven fabric coated with photosensitizer on the surface. The non-woven fabric was immersed in 120 ml of an aqueous solution of 25% DMAA, and passed nitrogen for 30 minutes, and then the sample cell was put into an ultraviolet irradiation device with nitrogen atmosphere to carry out ultraviolet irradiation grafting reaction, and the irradiation time was 45 minute. After the reaction, the non-woven fabric was taken out, placed in ethanol for ultrasonic cleaning for 30 minutes, and then washed with a large amount of water until the washing liquid had no foam and the surface of the non-woven fabric had no greasy feeling. The cleaned sample was placed in an o...

Embodiment 3

[0033] Set the areal density to 120g / m 2 , the average fiber diameter is 2.5 μm, the average pore size is 15 μm, the thickness is 1 mm, and the area is 10 × 10 cm 2The PBT non-woven block was put into a 4% ethanol solution of photosensitizer benzophenone in 80 ml, soaked for 30 minutes, taken out and air-dried to obtain a non-woven fabric coated with photosensitizer on the surface. The non-woven fabric was immersed in 120ml of an aqueous solution of 10% DMAA, and passed through nitrogen for 30 minutes, and then the sample cell was put into an ultraviolet irradiation device with a nitrogen atmosphere to carry out ultraviolet irradiation grafting reaction, and the irradiation time was 60 minute. After the reaction, the non-woven fabric was taken out, placed in ethanol for ultrasonic cleaning for 30 minutes, and then washed with a large amount of water until the washing liquid had no foam and the surface of the non-woven fabric had no greasy feeling. The cleaned samples were pl...

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Abstract

The invention provides a preparation method of carboxylic acid betaine modified non-woven fabric for hemofiltration, belonging to the field of biological medical material. The method comprises the following steps of: under the action of photosensitizer and ultraviolet light, grafting N, N dimethyl acrylamide (DMAA) with tert-amido, and then introducing propiolactone to react with the tert-amido to generate a carboxylic acid betaine group. The preparation method is simple in preparation process, easy to realize, explicit and reliable in mechanism; and the carboxylic acid betaine modified non-woven fabric is good in hydrophily and blood compatibility and can be applied to blood filter material and the other biological medical fields.

Description

technical field [0001] The invention belongs to a preparation method of a non-woven fabric in the field of biomedical materials, and particularly relates to a preparation method of a non-woven fabric modified by carboxylic acid betaine groups for blood filtration. Background technique [0002] Blood is one of the important substances necessary for the human body to maintain normal life activities, and blood components contain plasma and blood cells. Blood cells can be divided into red blood cells (7-8.5 μm in diameter), white blood cells (6-20 μm in diameter) and platelets (about 2-4 μm in diameter). Blood transfusions are often given to patients in hospitals. There is a large amount of data showing that during the blood transfusion process, due to the reaction of the human immune system to the allogeneic components, the leukocytes in the blood of the donor and the leukocyte antibodies in the blood of the recipient have an allogeneic reaction. It often causes non-hemolytic ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M14/32D06M14/28D06M13/228B01D39/16D06M101/32D06M101/20
Inventor 孙康杨超
Owner SUZHOU YITONG FILTER TECH
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