Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of total platycodin in medicine for treating and preventing ureaplasma urealyticum infectious diseases

A technology for infectious diseases and Ureaplasma urealyticum is applied in the application field of total saponins from Platycodon grandiflorum in the preparation of medicines for treating and preventing Ureaplasma urealyticum infectious diseases, so as to avoid toxic side effects and drug resistance, and to expand medicinal use. Scope and effect of market demand

Active Publication Date: 2013-11-06
黑龙江省中医研究院
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no relevant literature report on the anti-UU effect of platycodon saponins at home and abroad.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of total platycodin in medicine for treating and preventing ureaplasma urealyticum infectious diseases
  • Application of total platycodin in medicine for treating and preventing ureaplasma urealyticum infectious diseases
  • Application of total platycodin in medicine for treating and preventing ureaplasma urealyticum infectious diseases

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0019] Specific embodiment one: the application of Platycodon grandiflorum total saponins in the medicine for treating and preventing Ureaplasma urealyticum infectious diseases in this embodiment: Platycodon grandiflorum total saponins are used as active ingredients in medicines for treating and preventing Ureaplasma urealyticum infectious diseases, Platycodon grandiflorum The total saponin is one or a combination of bellflower acids, telegalic acids, bellflower diacids, and bellflower A lactone saponins.

[0020] When the total platycodon saponins are composed of two or more substances, they are mixed in any ratio.

[0021] The anti-MP test of Platycodon grandiflora total saponins in vitro is as follows:

[0022] 1 Experimental materials

[0023] The international standard strain of Ureaplasma urealyticum (ATCC27816) was purchased from the American Type Culture Collection.

[0024] Platycodon grandiflora total saponins, laboratory extraction, the total saponin content of th...

specific Embodiment approach 2

[0111] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is that the total saponins of Platycodon grandiflora are treated and prevented by oral administration, mucosal administration, skin administration, respiratory tract administration or injection administration and Ureaplasma urealyticum infection For diseases, the dosage for adults is 1-20mg / Kg body weight. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0112] Specific embodiment three: the difference between this embodiment and specific embodiment one is that bellflower acids, polygalic acids, bellflower diacids and bellflower A lactone saponins belong to 12-ene-oleanolic acid type pentacyclic triterpenes Saponin, its aglycone chemical general formula is as follows:

[0113]

[0114] Others are the same as in the first embodiment.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Application of total platycodin in a medicine for treating and preventing ureaplasma urealyticum infectious diseases relates to the application of the total platycodin in medicines and comprises that the total platycodin serves as an active component in the medicine for treating and preventing the ureaplasma urealyticum infectious diseases and is one of platycodon grandiflorum acids, senegeninic acids, platycodon grandiflorum diacids and platycodon grandiflorum acid A lactone class saponins or a composition of more of platycodon grandiflorum acids, senegeninic acids, platycodon grandiflorum diacids and platycodon grandiflorum acid A lactone class saponins. The total platycodin in the application has the function of resistance to ureaplasma urealyticum. Vitro tests improve that the minimal inhibitory concentration (MIC) value of the total platycodin resistant to the ureaplasma urealyticum (UU) is 16-32mumg / ml, minimal bactericidal concentration (MBC) is 32-64mumg / ml, and the resistance to the UU represents obvious real time and quantity effect relation. The vitro tests improve that after estradiol benzoate is injected into a small mouse in subcutaneous mode, the UU is infected by a vagina, vaginitis is caused to the small mouse, platycodin suppository is dosed through the vagina, the vaginal secretion UU culture positive rate can be reduced, pathological histology performance of vagina inflammatory diseases is improved, and the total platycodin has a curative effect on the UU infection vaginitis.

Description

technical field [0001] The invention relates to the application of total platycodon saponins in medicine. Background technique [0002] Ureaplasma urealyticum (UU) is one of the main pathogens of non-gonococcal urethritis, a sexually transmitted disease, with a high incidence. It can cause inflammation of the genitourinary system such as nongonococcal urethritis, endometritis, salpingitis, and prostatitis, and can cause male and female infertility, infertility, and complications such as intrauterine infection and abortion in pregnant women. [0003] Clinically, nongonococcal urethritis caused by UU has the characteristics of atypicality, stubborn relapse and protracted healing, and there is an upward trend in recent years. Antibiotics are the main treatment, and the drugs of choice are tetracyclines, macrolides, and quinolones. In recent years, due to the gradual increase of UU resistant strains to antibiotics, the drug resistance rate has increased year by year, and the e...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/70A61K31/704A61K36/34A61K9/02A61K9/08A61K9/16A61K9/19A61K9/20A61K9/48A61P31/04
Inventor 王伟明张俊威姚琳许庆瑞高菲
Owner 黑龙江省中医研究院