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Series solid-phase extraction (SPE) method for nitrosamine compounds in drinking water

A tandem solid-phase extraction and nitrosamines technology, which is applied in the field of tandem solid-phase extraction of nitrosamines in drinking water, to achieve the effects of easy-to-obtain materials, simple production, and convenient operation

Inactive Publication Date: 2012-07-18
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem that the existing solid-phase extraction method can only extract one or several nitrosamine compounds with similar polarity, and provide a tandem solid-phase extraction method for nitrosamine compounds in drinking water

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1) Assemble 200mg / 6ml Oasis HLB cartridges and 2 g / 6ml Coconut charcoal activated carbon SPE cartridges up and down sequentially into a series solid phase extraction column and install it on the solid phase extraction device.

[0027] 2) Use ultrapure water to accurately prepare 500ml aqueous solution containing 9 kinds of nitrosamine compound standard products (concentrations are 50ng / L respectively). Use 10ml of ultrapure water, methanol, dichloromethane, methanol, and ultrapure water to activate the installed tandem solid phase extraction column in sequence, avoiding the liquid to drain each time; use the negative pressure of the vacuum pump at a speed of 4~6ml / min Pass the prepared aqueous solution of nitrosamine compound through the column and drain it; use 30ml / s nitrogen flow to dry the solid-phase extraction column for 30 minutes; disassemble the series-connected solid-phase extraction column and elute with 10ml of dichloromethane respectively ; The combined elu...

Embodiment 2

[0029] 1) Assemble 200mg / 6ml Oasis HLB cartridges and 2 g / 6ml Coconut charcoal activated carbon SPE cartridges up and down sequentially into a series solid phase extraction column and install it on the solid phase extraction device.

[0030] 2) Use tap water to accurately prepare 500ml of an aqueous solution containing 9 kinds of nitrosamine compound standards (concentrations are 50ng / L respectively). Use 10ml of ultrapure water, methanol, dichloromethane, methanol, and ultrapure water to activate the installed tandem solid phase extraction column in sequence, avoiding the liquid to drain each time; use the negative pressure of the vacuum pump at a speed of 4~6ml / min Pass the prepared aqueous solution of nitrosamine compound through the column and drain it; use 30ml / s nitrogen flow to dry the solid-phase extraction column for 30 minutes; disassemble the series-connected solid-phase extraction column and elute with 10ml of dichloromethane respectively ; The combined eluents wer...

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Abstract

The invention discloses a series solid-phase extraction (SPE) method for nitrosamine compounds in drinking water. The method comprises the following steps of: 1) manufacture of a series solid-phase extraction column: assembling 200mg / 6ml of Oasis hydrophile-lipophile balance (HLB) small column and 2g / 6ml of Coconutcharcoal activated carbon SPE small column up and down in order by a connecting head to form the series solid-phase extraction column, and installing the series solid-phase extraction column onto a solid-phase extraction device; and 2) solid-phase extraction of the nitrosamine compounds: activating by using methanol and dichloromethane, treating water sample by the column, drying by using nitrogen flow, eluting by dichloromethane and carrying out nitrogen blowing concentration. The SPE method has higher recovery rate for nine nitrosamine compounds in the drinking water, is good in stability as well as simple and convenient in operation, and solves the problem that the existing SPE method only can be used for extracting one or more nitrosamine compound(s) with similar polarity, thus providing technical support for accurately measuring the concentration of multiple nitrosamine disinfection by-products in the drinking water.

Description

technical field [0001] The invention belongs to the field of water treatment, and in particular relates to a tandem solid-phase extraction method for nitrosamine compounds in drinking water. Background technique [0002] Nitrosamine compounds are a new type of drinking water disinfection by-products discovered in recent years. They are highly carcinogenic and mutagenic, and are recognized as one of the four major first-class carcinogens in the world. Ascertaining the concentration level of nitrosamine compounds in drinking water is of great significance to the protection of human health. [0003] At present, the enrichment methods of nitrosamines in drinking water at home and abroad mainly include liquid-liquid extraction and solid-phase extraction. Solid-phase extraction technology has been widely used in recent years because of its advantages of processing large water samples, using less organic solvents, and high recovery rates. Chinese invention patent 201010186268 dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D15/08C02F1/28G01N1/34G01N1/40
Inventor 周文军楼林洁陈翠苹
Owner ZHEJIANG UNIV
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