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Method for detecting content of bismuth in bismuth potassium citrate medicament

A bismuth potassium citrate and detection method technology, which is applied in the field of atomic absorption spectroscopic analysis, can solve the problems that the manual titration end point is not easy to control, the consumption of samples and solvents is large, and the loss of components to be measured, etc., and achieves fewer types of reagents , high accuracy and high reproducibility

Inactive Publication Date: 2012-07-18
长治学院
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition to preparing the EDTA standard solution required for the experiment, the complexometric titration method also needs to prepare buffers, indicators, masking solutions, and reference reagent solutions for calibrating the EDTA standard solution. There are many types of solutions that need to be prepared. It is cumbersome, consumes a lot of samples and solvents, and more importantly, the manual titration end point is not easy to control, and the operation process is easy to cause the loss of the components to be measured

Method used

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  • Method for detecting content of bismuth in bismuth potassium citrate medicament
  • Method for detecting content of bismuth in bismuth potassium citrate medicament
  • Method for detecting content of bismuth in bismuth potassium citrate medicament

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Take Livzon Dele Granules (product batch number 0910190) produced by Livzon Pharmaceutical Factory of Livzon Group as an example.

[0038] 1. Preparation of bismuth standard stock solution: Precisely weigh 0.2500g metal bismuth and place it in a beaker, add HNO with a volume ratio of 1:1 3 Dissolve 25 mL of the solution, and dilute it in a 250 mL volumetric flask with deionized water to obtain a bismuth standard stock solution with an acidity of 5% and a concentration of 1000 μg / mL.

[0039] 2. Preparation of bismuth standard analysis solution: pipette 10.00mL bismuth standard stock solution into a 100mL volumetric flask, and add 5% HNO 3 The solution was fixed to volume, and prepared as a bismuth standard analysis solution with a concentration of 100 μg / mL.

[0040] 3. Preparation of bismuth standard solution: pipette 0.00mL, 1.00mL, 2.00mL, 3.00mL, 4.00mL, 5.00mL, 10.00mL of bismuth standard analysis solution in seven 50mL volumetric flasks, and use 5% HNO 3 The sol...

Embodiment 2

[0050] In order to further test the accuracy of the analysis results of Example 1, the method of National Pharmacopoeia in 2010——complexometric titration was used to measure the sample of Example 1, and the difference between the results of the two methods was compared.

[0051] Prepare an EDTA solution with a concentration of about 0.05mol / L, with 0.05000mol / L Zn 2+ The standard solution was used for calibration to obtain an EDTA standard solution with an accurate concentration of 0.04996mol / L.

[0052] Accurately weigh a certain amount of Livzon Dele medicine, dissolve it in 50mL of water, and then add HNO with a volume ratio of 1:1 3 Dissolve 25mL of the solution, and dilute it with deionized water in a 250mL volumetric flask.

[0053] Draw 25.00mL of the above sample solution, and carry out complexometric titration with EDTA standard solution according to the Pharmacopoeia method, and the experimental results are listed in Table 2.

[0054]

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Abstract

The invention relates to a method for detecting the content of bismuth in a bismuth potassium citrate medicament. According to the method, a sample is dissolved with acid; and the content of the bismuth in the bismuth potassium citrate medicament is determined by adopting an air-acetylene flame atomic absorption spectrometry and a bismuth hollow cathode lamp according to the absorption of a bismuth element in the medicament for a bismuth characteristic line. The method for detecting the content of the bismuth in the bismuth potassium citrate medicament by adopting the atomic absorption spectrometry is free from troublesome pretreatment, fewer in reagent types, simple in solution preparation and simple and quick in operation; and in addition, the method has the advantages of favorable selectivity and reproducibility, high accuracy, consistent measuring result with that of an official method, satisfaction in result and practical value.

Description

technical field [0001] The invention belongs to the technical field of atomic absorption spectrometry and relates to a detection method for measuring bismuth content by atomic absorption spectrometry. Background technique [0002] Livzon Dele is an anti-peptic ulcer drug, used to treat gastric ulcer, duodenal ulcer, compound ulcer, multiple ulcers and anastomotic ulcer. The main ingredient of Livzon Dele is bismuth potassium citrate, which is a bismuth-containing compound with variable composition, and the excipients are mannitol and sodium carboxymethylcellulose. Bismuth can form a layer of bismuth-protein coagulation film on the ulcer surface of the stomach, protect it from gastric acid and protease erosion, and promote the healing of the ulcer surface. But because of this, it also causes long-term and chronic absorption of bismuth, which makes bismuth accumulate in the body. If bismuth is deposited in the brain, symptoms such as headache, insomnia, and memory loss may o...

Claims

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Application Information

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IPC IPC(8): G01N21/33
Inventor 晨晓霓刘斌张宝秀杜海丽
Owner 长治学院
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