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Method for simultaneously determining contents of multiple ingredients in multivitamin amino acid chewing pill

An amino acid, chewable tablet technology, applied in the field of analytical chemistry, can solve complex problems and achieve the effect of simple method, strong specificity, and improved sensitivity and accuracy

Inactive Publication Date: 2015-01-07
HEBEI KEXING PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional detection of amino acid content in preparations uses special amino acid columns and special reagents to prepare mobile phases, which is more complicated and expensive

Method used

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  • Method for simultaneously determining contents of multiple ingredients in multivitamin amino acid chewing pill
  • Method for simultaneously determining contents of multiple ingredients in multivitamin amino acid chewing pill
  • Method for simultaneously determining contents of multiple ingredients in multivitamin amino acid chewing pill

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Embodiment

[0047] Example A method for simultaneously determining the contents of multiple components in multidimensional amino acid chewable tablets

[0048] This measurement method uses HPLC method to simultaneously determine L-glutamine, cysteine ​​hydrochloride and VB in multidimensional amino acid chewable tablets 2 content. The chromatographic conditions of the method are:

[0049] (1) Chromatographic column Shimadzu VP-ODS (250mm×4.6mm, 5μm);

[0050] (2) The mobile phase is an aqueous solution of acetonitrile and ion-pairing reagent with a mixing ratio (volume ratio) of 10:90; the flow rate of the mobile phase is 1.2 mL / min, the injection volume is 20 μL, and the column temperature is 35 °C. in:

[0051] The aqueous solution of ion-pairing reagent is 0.0865% aqueous solution of sodium octane sulfonate prepared by dissolving 0.865g sodium octane sulfonate plus 1000mL secondary deionized water (it can also be replaced by aqueous solution of sodium heptane sulfonate) , adjust ...

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Abstract

The invention discloses a method for simultaneously determining contents of multiple ingredients in a multivitamin amino acid chewing pill, namely a method for determining the contents of L-glutamine, cysteine hydrochloride and vitamin B2 (VB2) in the multivitamin amino acid chewing pill by means of high performance liquid chromatography (HPLC). The chromatographic conditions of the method include: (1) chromatographic column Shimadzu VP-ODS (250mm*4.6mm, 5 mu m) is used; (2) mobile phase is a mixture of acetonitrile and an ion-pairing agent aqueous solution at a mixing ratio of 10:90; (3) detection wavelength of an ultraviolet detector is 215 nm; and flow rate of the mobile phase is 1.2 mL / min, sample volume is 20 mu L, and the column temperature is 35 DEG C. The determination method is simple to operate, capable of improving determination sensitivity and accuracy degree, applicable to samples interfered by color, and suitable for determining the contents of the L-glutamine, the cysteine hydrochloride and the VB2 in the multivitamin amino acid chewing pill.

Description

technical field [0001] The invention belongs to the field of analytical chemistry and relates to the quantitative determination of L-glutamine, cysteine ​​hydrochloride and vitamin B in preparations 2 The method for content, specifically a method for simultaneously determining the content of multiple components in the multidimensional amino acid chewable tablet. Background technique [0002] Domestic studies use HPLC method to determine the content of vitamins in medicines, health products, foods, etc., but the amino acids (L-glutamine, cysteine ​​hydrochloride) and vitamins (VB 2 ) in the same system, the liquid phase method of determining the content together is less studied. At present, there is no such report in the domestic literature. The traditional detection of the content of amino acids in preparations uses special amino acid columns and special reagents to prepare mobile phases, which is more complicated and expensive. Contents of the invention [0003] The te...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
Inventor 魏桂香田会彦张江艳王付平
Owner HEBEI KEXING PHARMA
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